NTUBST2019

• 美國德州大學 微生物學 博士 (1996/08 ~ 2002/05)
• 國立台灣大學 農業化學 碩士 (1991/09 ~ 1993/06)
• 國立台灣大學 農業化學 學士 (1987/10 ~ 1991/06)

一、發炎反應之調控機轉及免疫調節藥物之研發

微生物感染及組織損傷時可活化免疫系統引起發炎反應，進而對抗微生物感染、清除死亡細胞並促進組織修復。但過度的發炎反應亦可能造成過多的免疫細胞浸潤並產生過量的細胞激素，導致細胞激素風暴、組織損傷及器官功能衰竭，如COVID-19所引起之急性呼吸窘迫症候群。在過敏反應及自體免疫反應發生時，持續的發炎反應亦可造成組織損傷及纖維化等不可逆的病變。此外在癌症發生過程中，腫瘤微環境的發炎反應則可促進癌細胞生長，並阻止免疫系統對癌細胞進行攻擊。

本實驗室的研究重點在探討發炎反應之調控機轉，如發炎細胞(嗜中性球、嗜酸性球、單核球等)如何降解胞外基質並浸潤至發炎組織。研究發現之關鍵調控分子，將可作為新藥開發之標的，期望能藉此調節因感染、組織損傷、癌症、過敏及自體免疫等引起之發炎反應。

二、黏膜疫苗研發

多數病原菌皆由黏膜表面入侵身體，而在黏膜組織則有特化的淋巴組織可針對入侵之病原產生免疫反應，並分泌IgA抗體將病原菌予以中和清除。在疫苗設計上，若能經由黏膜組織(如呼吸道及消化道)給予抗原而誘發免疫反應，將可更有效的預防病原菌感染。我們目前也致力於研發新的黏膜疫苗佐劑及傳輸系統。

• 生化科技學系 副教授 (2014/08 ~ now)
• 生化科技學系 助理教授 (2006/08 ~ 2014/07)
• 微生物與生化學研究所 助理教授 (2006/08~ 2009/07)
• 美國麻州大學醫學院 博士後研究 (2003/08 ~ 2006/08)
• 美國德州大學醫學院蓋維斯頓分校 博士後研究 (2002/08 ~ 2003/08)
• 台大醫學院微生物學研究所 助教 (1995/08 ~ 1996/07)

專業學術服務

• 台灣農學化學會 理事 (2015/07 ~ now)
• 台大生化科技系系友會 秘書長 (2015/10 ~ now)
• 台大生化科技系系友會 監事 (2012/09 ~ 2015/09)
• 台灣農業化學會 秘書長 (2011/07 ~ 2015/07)
• 台灣農業化學會 學術組長 (2007/07 ~ 2011/07)

• Sigma Xi, The Scientific Research Society 會員 (2002 ~ now)
• ZESPRI第二屆百萬論文大賞 論文獎 (2008)
• 美國 Marquis Who's  Who, Who's Who in Medicine and Healthcare (2005)
• 美國 Marquis Who's  Who, Who's Who in America (2004)

    (*Corresponding author)

1. Lu HY, Huang PH, Lee TW, Chang HW, Chen NY, Zhuang YJ, Yuan TT, Chen CJ*. Enolase-1 is a key regulator of neutrophil recruitment during acute inflammation. 2025; Immunology (in press) https://doi.org/10.1111/imm.70034
2. Yang JY, Chen KL, Lin YC, Chiu HC, Hsieh HT, Chen CJ*. Ganoderma formosanum polysaccharides enhance antitumor immune responses by downregulating the differentiation of myeloid-derived suppressor cells and tumor-associated macrophages. 2024; bioRxiv 2024.12.23.630057; doi: https://doi.org/10.1101/2024.12.23.630057
3. Huang WC, Chuang CF, Huang YT, Chung IC, Chen ML, Chuang TY, Yang XL, Chou YY, Liu CH, Chen NY, Chen CJ, Yuan TT*. Monoclonal enolase-1 blocking antibody ameliorates pulmonary inflammation and fibrosis. 2023; Respir Res. 24(1):280.
4. Lee HY, Chen CC, Pi CC, Chen CJ*. Aspergillus oryzae Fermentation Extract Alleviates Inflammation in Mycoplasma pneumoniae Pneumonia. Molecules 2023; 28(3): 1127.
5. Li CJ, Jiang CL, Chao TL, Lin SY, Tsai YM, Chao CS, Su YT, Chen CJ, Chang SY*, Lin FJ*, Chang SC*. Elicitation of potent neutralizing antibodies in obese mice by ISA 51-adjuvanted SARS-CoV-2 spike RBD-Fc vaccine. Appl Microbiol Biotechnol 2023; 107(9): 2983-95.
6. Huang TR, Jou SB, Chou YJ, Yi PL, Chen CJ, Chang FC*. Interleukin-1 receptor (IL-1R) mediates epilepsy-induced sleep disruption. BMC Neurosci. 2016; 17: 74.
7. Chen CL, Tsai WH, Chen CJ, Pan TM*. Centella asiatica extract protects against amyloid β_1-40-induced neurotoxicity in neuronal cells by activating the antioxidative defence system. J Tradit Complement Med. 2016; 6(4): 362-9.
8. Pi CC, Wang HY, Lu CY, Lu FL, Chen CJ*. Ganoderma  formosanum polysaccharides attenuate Th2 inflammation and airway hyperresponsiveness in a murine model of allergic asthma. SpringerPlus 2014; 3: 297. 
9. Chang YL, Chen TH, Wu YH, Chen GA, Weng TH, Tseng PH, Hsieh SL, Fu SL, Lin CH, Chen CJ, Chu CL, Chio IIC, Mak TW, Chen NJ*. A novel TLR2-triggered signaling crosstalk synergistically intensifies TNF-mediated IL-6 induction. J Cell Mol Med. 2014; 18(7): 1344-57.
10. Pi CC, Chu CL, Lu CY, Zhuang YJ, Wang CL, Yu YH, Wang HY, Lin CC, Chen CJ*. Ganoderma formosanum polysaccharides function as a Th1 adjuvant and stimulate cytotoxic T cell responses in vivo. Vaccine 2014; 32(3): 401-8.
11. Wang JT, Chang LS, Chen CJ, Doong SL, Chang CW, Chen MR*. Glycogen synthase kinase 3 negatively regulates interferon regulatory factor 3 transactivation through phosphorylation at its linker region. Innate Immun. 2014; 20(1): 78-87. 
12. Tzeng HT, Tsai HF, Chyuan IT, Liao HJ, Chen CJ, Chen PJ, Hsu PN*. Tumor necrosis factor-alpha induced by hepatitis B virus core mediating the immune response for hepatitis B viral clearance in mice model. PLoS One 2014; 9(7): e103008.
13. Wang CL, Lu CY, Hsueh YC, Liu WH, Chen CJ*. Activation of antitumor immune responses by Ganoderma formosanum polysaccharides in tumor-bearing mice. Appl Microbiol Biotechnol. 2014; 98(22): 9389-98.
14. Chung CH, Yeh SC, Chen CJ*, Lee KT*. Coenzyme Q0 from Antrodia cinnamomea in submerged cultures induces reactive oxygen species-mediated apoptosis in A549 human lung cancer cells. Evid Based Complement Alternat Med. 2014; 2014: 246748.
15. Wang CL, Lu CY, Pi CC, Zhuang YJ, Chu CL, Liu WH, Chen CJ*. Extracellular polysaccharides produced by Ganoderma formosanum stimulate macrophage activation via multiple pattern-recognition receptors. BMC Complement Altern Med. 2012; 12(1): 119.
16. Wang CL, Pi CC, Kuo CW, Zhuang YJ, Khoo KH, Liu WH, Chen CJ*. Polysaccharides purified from the submerged culture of Ganoderma formosanum stimulate macrophage activation and protect mice against Listeria monocytogenes infection. Biotechnol Lett. 2011; 33(11): 2271-8.
17. Kono H, Chen CJ, Ontiveros F, Rock KL*. Uric acid promotes an acute inflammatory response to sterile cell death in mice. J Clin Invest. 2010; 120(6): 1939-49.
18. Chen CJ, Kono H, Golenbock D, Reed G, Akira S, Rock KL*. Identification of a key pathway required for the sterile inflammatory response triggered by dying cells. Nat Med. 2007; 13(7): 851-6.
19. Chen CJ, Shi Y, Hearn A, Fitzgerald K, Golenbock D, Reed G, Akira S, Rock KL*. MyD88-dependent IL-1 receptor signaling is essential for gouty inflammation stimulated by monosodium urate crystals. J Clin Invest. 2006; 116(8): 2262-71.
20. Rock KL*, Hearn A, Chen CJ, Shi Y. Natural endogenous adjuvants. Springer Semin Immunopathol. 2005; 26(3): 231-46.
21. Chen CJ, Sugiyama K, Kubo H, Huang C, Makino S*. Murine coronavirus nonstructural protein p28 arrests cell cycle in G0/G1 phase. J Virol. 2004; 78(19): 10410-9.
22. Chen CJ, Makino S*. Murine coronavirus replication induces cell cycle arrest in G0/G1 phase. J Virol. 2004; 78(11): 5658-69.
23. Narayanan K, Chen CJ, Maeda J, Makino S*. Nucleocapsid-independent specific viral RNA packaging via viral envelope protein and viral RNA signal. J Virol. 2003; 77(5): 2922-7.
24. Chen CJ, Makino S*. Murine coronavirus-induced apoptosis in 17Cl-1 cells involves a mitochondria-mediated pathway and its downstream caspase-8 activation and bid cleavage. Virology. 2002; 302(2): 321-32.
25. Chen CJ, An S, Makino S*. Induction of apoptosis in murine coronavirus-infected 17Cl-1 cells. Adv Exp Med Biol. 2001; 494: 615-20.
26. An S^†, Chen CJ^†, Yu X, Leibowitz JL, Makino S*. Induction of apoptosis in murine coronavirus-infected cultured cells and demonstration of E protein as an apoptosis inducer. J Virol. 1999; 73(9): 7853-9.  (^†equal contribution)
27. Huang JH*, Chen CJ, and Su YC. Production of chitinolytic enzymes from a novel species of Aeromonas. J Ind Microbiol. 1996; 17: 89-95.