跳到主要內容區塊

NTUBST2019

兼任教師

mobile botton

search

搜尋搜尋
  • 進階搜尋

上方連結

下方連結

上方連結

search

搜尋搜尋
  • 進階搜尋
back to top
:::

兼任教師

網頁功能

羅世皓 客座教授
連絡資訊


李家瑋 助理教授

羅世皓 (Su-Hao Lo) 客座教授

國家衛生研究院 分子與基因醫學研究所

  • 電話 ：037-206166 #35300
  • E-mail ：shlo@nhri.edu.tw
  • 研究專長 ：細胞訊號傳導、癌症發展、腎臟病成因、組織修復及細胞遷移

學歷


  • 1994-1998   Postdoctoral Fellow, Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL, USA

 

  • 1988-1993   Ph.D., Cell and Developmental Biology at Harvard Medical School, Harvard University, Cambridge, MA, USA

 

  • 1982-1986   BS, Department of Agricultural Chemistry.  National Taiwan University, Taipei, Taiwan

研究焦點


  • My overall research interest is to understand how cells communicate with each other and with their environments. These communications include both outside-in and inside-out signals and are essential for numerous biological events. In a multicellular organism, cell-cell interactions and cell-matrix interactions play critical roles in cellular communication. Focal adhesions are integrin-mediated junctions that attach various cell types to their underlying substratum. They are signal transduction organelles mediating diverse biological processes, including cell proliferation, attachment, migration, death, polarization, homeostasis, and differentiation.  As such, focal adhesion dysfunction is known to have profound repercussions in embryogenesis, tissue development and repair, as well as in many pathological conditions, including various forms of cancer and kidney diseases. My contributions to understanding the focal adhesion tensin family, the DLC1 family, and their associated networks span over 30 years, during which I have participated in nearly all the major breakthroughs in the field. This includes the identification of all four genes of the tensin family, in vitro characterization of the molecules, functional analyses of knockout/knockin animal models, their various roles in cancer or other diseases, and the application of nanotechnology for research.

 

  • In addition to cancer and renal diseases, my recent research program also includes phase separation of focal adhesion proteins. Although previous reports suggest that phase separation of focal adhesion proteins may serve as precursors for focal adhesion assembly, our live cell studies indicate that phase separation of TNS1 is involved in focal adhesion disassembly, and the presence of TNS1 condensates is regulated by mitosis. These observations open many new research directions in the field of phase separation in conjunction with focal adhesions, and our model offers an excellent system for these studies.

 

  • In my new role at IMGM, we will apply genomic, genetic, and molecular approaches to understand the causes, develop strategies, and ultimately reduce the number of patients or the disease burden in those suffering from common diseases, as well as other understudied diseases in Taiwan. This will involve large teamwork and, more critically, collaboration with patients and experts in relevant fields.

主要經歷


  • 2024/11- present    Visiting Professor, Department of Biochemical Science and Technology, National Taiwan University, Taiwan
  • 2024/10- present    Distinguished Investigator & Director, Institute of Molecular and Genomic Medicine, National Heath Research Institutes, Taiwan
  • 2024- present    YuShan Scholar, Cancer and Immunology Research Center, National Yang Ming Chiao Tung University, Taiwan
  • 2024- present    Professor Emeritus, Department of Biochemistry and Molecular Medicine, University of California-Davis, Davis, CA
  • 2023/3-5    Visiting scholar. Institute of Biomedical Sciences, Academia Sinica, Taiwan
  • 2013/11-12    Visiting scholar. Institute of Biological Chemistry, Academia Sinica, Taiwan
  • 2009- 2024    Professor, Department of Biochemistry and Molecular Medicine, University of California-Davis, Davis, CA
  • 2007/5-8    Visiting scholar. Department of Molecular Medicine, Max Planck Institute for Biochemistry, Martinsreid. Germany
  • 2007-2009    Associate Professor, Center for Tissue Regeneration and Repair, Department of Biochemistry and Molecular Medicine, University of California-Davis, Davis, CA
  • 2005-2007    Associate Professor, Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis, Davis, CA
  • 2005-2024    Member of the graduate group of the Comparative Pathology (now GGIP) University of California-Davis
  • 2003-2024    Member of the graduate group of Pharmacology and Toxicology University of California-Davis
  • ​​​1998-2024    Member of the Cancer Center, University of California-Davis
  • 1998-2024    Member of the graduate group of Cell and Developmental Biology (now BMCDB) University of California-Davis
  • 1998-2005    Assistant Professor, Center for Tissue Regeneration and Repair, Department of Orthopaedic Surgery, University of California Davis-Davis, CA, USA​​​​​​​
  • 1994-1998    Postdoctoral Fellow, Howard Hughes Medical Institute, Department of Molecular Genetics and Cell Biology, The University of Chicago, IL, USA

榮譽獎項


  • 玉山學者 (2024-2027)

代表著作


  1. Kim, D.S., Cheah, J.S., Zhao, K.X., Foust, S.R., Lee, J.Y.R., Lo, S.H., Heinrich, V., Yamada, S. Tandem LIM domain containing proteins, LIMK1 and LMO1, directly bind to force bearing keratin intermediate filaments. Cell Rep. 43(7):114480.doi: 10.1016/j.celrep.2024.114480. Epub 2024 Jul 13.
  2. 2024 Fan, W., Adebowale, K., Li, Y., Rabbi, M.F., Vancza, L., Chen, D., Kunimoto, K., Mozes, G., Li, Y., Tao, J., Monga, S., Charville, G., Wells, R., Dhanasekaran, R., Singhi, A., Geller, D., Lo, S.H., Hodgson, L., Charu, V., and Torok, N. Extracellular Matrix Viscoelasticity Promotes Liver Cancer Progression in Pre-Cirrhotic NASH. Nature, 626:635-642 DOI 10.1038/s41586-023-06991-9
  3. 2023 Lee, Y.R., Yamada, S., and Lo, S.H. Phase transition of tensin-1 during the focal adhesion disassembly and cell division. Proc. Natl. Acad. Sci 120 (15) e2303037120
  4. 2023 Huang, C.W. and Lo, S.H. Tensins in kidney function and diseases. Life, 13(6), 1244; https://doi.org/10.3390/life13061244
  5. 2022 Merour, E., Hmidan, H., Marie, C., Helou, PH., Lu, H., Potel, A., Hure, JB., Clavairoly, A., Shih, YP., Goudarzi, S., Dussaud, , Ravassard, P., Hafizi, S., Lo,, S.H., Hassan, BA., and Parras, C. Transient regulation of focal adhesion via Tensin3 is required for nascent oligodendrocyte differentiation. eLife 11:e80273. doi: 10.7554/eLife.80273
  6. 2022 Chiu, C.L., Hong, S.Y., Tan, Y., Lee, Y.R., Shih, Y.P., Tepper, C.G., and Lo, S.H. C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice. Genes and Diseases https://doi.org/10.1016/j.gendis.2022.05.035
  7. 2021 Liao, Y.C. and Lo, S.H. Tensins – emerging insights into their domain functions, biological roles and disease relevance. J Cell Sci 134 (4): jcs254029 //doi.org/10.1242/jcs.254029
  8. 2020 Ogorodnik, E., Karsai, A., Wang, K.H., Liu, F.T., Lo, S.H., Pinkerton, K., Gilbert, B., Haudenschild, D., Liu, G.Y. Direct Observations of Silver Nanowire-Induced Frustrated Phagocytosis among NR8383 Lung Alveolar Macrophages. J Phys Chem B 124: 11584−11592 DOI:1021/acs.jpcb.0c08132
  9. 2020 Tan, Y. and Lo, S.H. Endothelial DLC1 is dispensable for liver and kidney function in mice. Genes and Diseases https://doi.org/10.1016/j.gendis.2020.11.012
  10. 2019 Bruns A and Lo SH. TNS1 regulates Pharyngeal pumping in Caenorhabditis elegans. BBRC 522(3):599-603.doi: 10.1016/j.bbrc.2019.11.153. Epub 2019 Nov 27.
  11. 2019 Wu, Z. Y., Chiu, C. L., Lo, E., Lee, Y. R., Yamada, S., and Lo, S. H.*. Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases Cell Death & Disease 10:871 doi: 10.1038/s41419-019-2119-7. PMID:31740667 PMCID: PMC6861224
  12. 2019 Cheah, J. S., Jacobs, K. A., Heinrich, V., Lo, S. H., and Yamada, S. Force-induced recruitment of cten along keratin network in epithelial cells. Proc. Natl. Acad. Sci 116:19799-19801
  13. 2019 Hong, S. Y., Shih, Y. P., Lo, A., Lo, S. H. Identification of subcellular targeting sequences of Cten reveals its role in cell proliferation. BBA Molecular Cell Research 1866(3):450-458. 1016/j.bbamcr.2018.10.008. Epub 2018 Oct 13 PMID:30321615
  14. 2017 Shih, Y. P., Yuan, S. Y., Lo, S. H. Down-regulation of DLC1 in endothelial cells compromises the angiogenesis process. Cancer Letters 398:46-51. PMID:28408355
  15. 2017 Lo, S. H. Quick guide: Tensins. Current Biology 27(9):R331-R332. PMID:28486112
  16. 2016 Hong, S. Y., Shih, Y.P., Sun, P., Hsieh, W. J., Lin, W. C. and Lo, S. H., Down-regulation of tensin2 enhances tumorigenicity and is associated with a variety of cancers. Oncotarget 7:38143-38153
  17. 2016 Yang, K., Wu, W. M., Chen, Y. C., Lo, S. H., and Liao Y.C. ΔNp63α Transcriptionally Regulates the Expression of CTEN that Is Associated with Prostate Cell Adhesion. PLoS ONE 11(1):e0147542.
  18. 2015 Shih, Y. P., Sun, P., Wang, A., Lo, S. H. Tensin1 positively regulates RhoA activity through its interaction with DLC1. BBA Molecular Cell Research. 1853:3258-65. PMID:26427649
  19. 2015 Dina, C., Bouatia-Naji, N., Tucker, N., Delling, F.N., Toomer, K., Durst, R., Perrocheau, M., Fernandez-Friera, L., Solis, J., Tourneau, T., Chen, M.H., Probst, V., Bosse, Y., Pibarot, P., Zelenika, D., Lathrop, M, Hercberg, S., Rousse, R., Benjamin, E. J., Bonnet, F., Lo, S. H., Dolmatova, E., Simonet, F., Lecointe, S., Kyndt, F., Redon, R, Marec H., Froguel, P., Ellinor, P. T., Vasan, R. S., Bruneval, P., Norris, R. A., Milan, D. J., Slaugenhaupt, S. A., Levine, R. A., Schott, J., Hagege, A. A., Jeunemaitre, X. Genetic association highlights biological pathways underlying mitral valve prolapse. Nat Genetics 47(10):1206-11. PMID:26301497
  20. 2014 S.H. C-terminal tensin-like (CTEN): a promising biomarker and target for cancer. Int J Biochem Cell Biol. 51:150-4. PMCID:PMC4038153
  21. 2014 Hung, S.Y., Shih, Y.P., Chen, M., and Lo, S.H. Up-regulated cten by FGF2 contributes to FGF2-mediated cell migration. Mol Carcinog. 53:787-792. PMID: 23625726 PMCID:PMC4388201
  22. 2013 Hong, S. Y., Shih, Y. P., Li, T., Carraway, K., Lo, S.H. CTEN prolongs signaling by EGFR through reducing its ligand-induced degradation. Cancer Res. 73(16):5266-76. PMCID:PMC3745516
  23. 2013 Fujita, M., Ieguchi, K., Fong, A., Wilkerson, C., Chen, J.Q, Wu, M., Lo, S.H., Cheung, ATW., Wilson, M.D., Cardiff, R.D. , Borowsky, A.D, Yoko K. Takada, YK, and Takada, Y. An integrin-binding-defective mutant of insulin-like growth factor-1 (R36E/R37E IGF1) acts as a dominant-negative antagonist of IGF1R and suppresses tumorigenesis, while the mutant still binds to IGF1R. J Biol Chem. 288(27):19593-603
  24. 2013 Chen, N.T., Kuwabara, Y., Conley, C., Liao, Y. C., Hong, S. Y., Chen, M., Shih, Y. P., Chen, H.W., Hsieh F., Lo, S. H. Phylogenetic analysis, expression patterns, and transcriptional regulation of human CTEN gene. Gene 520(2):90-7. PMID: 23500447
  25. 2012 Li, J.R., Shi, L., Deng, Z., Lo, S. H., Liu, G.Y. Nanostructures of designed geometry and functionality enable regulation of cellular signaling processes. Biochemistry 51:5876- 5893. PMID: 22783801
  26. 2012 Shih Y.P., Takada, Y., Lo, S.H. Silencing of DLC1 promotes PAI-1 expression and reduces normal cell migration. Mol Cancer Res. 10:34-39. PMCID:PMC3262057
  27. 2012 Shi L, Li, J.R., Shih, Y.P., Lo, S. H., Liu, G. Y., Nanogratings of fibronectin provide an effective biochemical cue for regulating focal adhesion and cellular structure. Nano Res 5(8): 565–575
  28. 2012 Zimmer, C.C., Shi, L., Shih, Y.P., Li, J., Jin, LW, Lo, S.H. Liu, G.Y. F-Actin reassembly during focal adhesion impacts single cell mechanics and nanoscale membrane structure. Science China Chemistry, 55(9):1922-1930
  29. 2011 Albasri, A., Al-Ghamdi, S., Fadhil, W., Aleskandarany, M., Liao, Y.C., Jackson, D., Lobo, D.N., Lo, S. H., Kumari, R., Durrant, L., Watson, S., Kindle, K.B., Ilyas, M. Cten signals through Integrin-linked Kinase (ILK) and may promote metastasis in colorectal cancer. Oncogene 30(26):2997-3002.
  30. 2010 Shih, Y.P., Liao, Y.C., Lin, Y., Lo, S. H. DLC1 negatively regulates angiogenesis in a paracrine fashion. Cancer Res 70:8270-8275. PMID: 20861185.
  31. 2010 Lin, Y., Chen, T., Shih, Y. P., Liao, Y. C., Xue, L., and Lo, S. H, DLC2 modulates angiogenic responses in vascular endothelial cells by regulating cell attachment and migration. Oncogene 29:3010-3016. PMCID:PMC2874629
  32. 2010 Wu. Z., Chang, P.C., Yang, Y.C., Chu, C. Y., Wang, L. Y., Chen, N. T., Desai, S. J., Lo, S. H., Evans, C. P., Lam, K. S., Kung, H. J. Autophagy blockade sensitizes prostate cancer cells towards Src family kinase inhibitors. Genes and Cancer 1:40-49. PMCID: PMC2930266
  33. 2009 Hsieh S. C., Chen, N. T., Lo, S. H. Conditional loss of PTEN leads to skeletal abnormalities and lipoma formation. Mol Carcinog. 48:545-552. PMID: 18973188
  34. 2009 Liao, Y. C., Chen, N. T., Shih Y. P., Dong, Y., Lo, S. H. Up-regulation of C-terminal tensin-like molecule promotes the tumorigenicity of colon cancer cells through b-catenin. Cancer Res 69:4563- 4566. PMCID: PMC2692076
  35. 2009 Lulevich, V., Shih, I. P., Lo, S. H., and Liu, G. Y. Cell tracing dyes significantly change single cell mechanics. J Phys Chem 113:6511-6519. PMCID: PMC2698896
  36. 2008 Liao, Y. C., Shih, I. P., and Lo, S. H. Mutations in DLC-1’s focal adhesion targeting region attenuated its expression and function. Cancer Res 68:7718-7722. PMCID: PMC2597479
  37. 2008 Liao, Y. C. and Lo, S. H. Deleted in Liver Cancer-1 (DLC-1): a tumor suppressor not just for liver. Int J Biochem Cell Biol. 40:834-847. PMCID: PMC2323245
  38. 2007 Katz, M., Amit, I., Citri, A., Shay, T., Carvalho, S., Lavi, S., Milanezi, F., Lyass, L., Amariglio, N., Jacob-Hirsch, J., Ben-Chetrit, N., Tarcic, G., Lindzen, M., Avraham, R., Liao, Y. C., Trusk, P., Lyass, A., Rechavi, G., Spector, N. L., Lo, S. H., Schmtt, F., Bacus, S. S., Yarden, Y. A reciprocal tensin3-cten switch mediates EGF-driven mammary cell migration. Nat Cell Biol. 9:961-969.
  39. 2007 Eto, M., Kirkbride, J., Elliott, E., Lo, S. H., Brautigan, D. L. Association of the tensin N-terminal PTP domain with alpha isoform of protein phosphoatase-1 in focal adhesions. J Biol Chem. 282:17806-17815.
  40. 2007 Lo, S.H. Reverse interactomics: from peptides to proteins and then to functions. ACS Cell Biol. 2:93-95.
  41. 2007 Liao, Y.C., Si, L., deVere White, R., and Lo, S. H. The phosphotyrosine-independent interaction of DLC-1 and the SH2 domain of cten regulates focal adhesion localization and growth suppression activity of DLC-1. J Cell Biol. 176:43-49. PMCID: PMC2063623
  42. 2006 Lo, S. H. Focal adhesions: what’s new inside. Dev Biol. 294:280-91
  43. 2006 You, Z., Shi, X. B., DuRaine, G., Haudenschild, D., Tepper, C. G., Lo, S. H., Gandour-Edwards, R., deVere While, R., Reddi, A. H. Interleukin-17 receptor-like gene is a novel anti-apoptotic gene highly expressed in androgen independent prostate cancer. Cancer Res. 66:175-183.
  44. 2006 Hu, L. Y., Tepper, C., Lo, S. H., and Lin, W. C. An Efficient Strategy to Identify Early TPA-Responsive Genes during Differentiation of HL-60 Cells. Gene Expression, 13:179-189
  45. 2005 Chen, N. T., and Lo, S. H. Role of talin2 in mouse development and survival. BBRC 337:670-676.
  46. 2005 Lo, S. S., Lo, S. H., and Lo, S. H. Cleavage of cten by caspase 3 during apoptosis. Oncogene 24:4311-4314.
  47. 2005 Chiang, M. K., Liao, Y.C., Kuwabara, Y, and Lo, S. H. Inactivation of tensin3 in mice results in growth retardation and postnatal lethality. Dev Biol. 279:368-377.
  48. 2004 Cui, Y., Liao, Y.C. and Lo, S. H. Epidermal growth factor modulates tyrosine phosphorylation of a novel tensin family member, tensin3. Mol Cancer Res. 2:225-232
  49. 2004 Lo, S. H. Molecules in focus: Tensin. Int J Biochem Cell Biol. 36:31-34.
  50. 2003 Chen, H. and Lo, S. H. Regulation of tensin-promoted cell migration by its focal adhesion-binding and Src Homology 2 domains. Biochem J. 370:1039-1045.
  51. 2002 Lo, S. H. and Lo, T. B. CTEN, a C-terminal tensin-like protein with prostate restricted expression, is down regulated in prostate cancer. Cancer Res. 62:4217-4221.
  52. 2002 Chen, H., Duncan, I. C., Bozorgchami, H., and Lo, S. H. Tensin1 and a previously undocumented family member, tensin2, positively regulate cell migration. Proc. Natl. Acad. Sci. 99:733-738
  53. 2002 Vinall, R. L., Lo, S. H. and Reddi, A. H. Bone morphogenetic protein 7 and cellular context regulate chondrocyte cytoskeleton and influence phenotype. Exp. Cell Res., 272: 32-44.
  54. 2001 Ishii, A., and Lo, S. H. A role of tensin in skeletal muscle regeneration. Biochem J. 356:737-745.
  55. 2001 Guo, L., Burke, P., Lo, S. H., Gandour-Edward, R., Lau, D. Quantitative analysis of angiogenesis using confocal laser scanning microscopy. ANGIOGENESIS. 4:187-91.
  56. 2000 Chen, H., Ishii, A., Wong, W., Chen, L. B., and Lo, S. H. Molecular characterization of human tensin. Biochem J. 351:403-411.
  57. 1999 Tikoo, A., Cutler, H., Lo, S. H., Chen, L. B., Maruta, H. Treatment of RAS-induced cancers by F-actin cappers, tensin and chaetoglobosin K, in combination with the caspase-1 inhibitor N1445.  Cancer J Sci Am. 5:293-300.
  58. 1999 Lo, S. S., Lo, S. H., Wang, S. C., Hung, M. C. Focal contact formation is inhibited in cell transformed by p185neu. Mol Carcinog. 25(2):150-4.
  59. 1997 Fuchs, E., Dowling, J., Segre, J., Lo, S. H., Yu, Q. C. Integrators of epidermal growth and differentiation:  distinct functions for b1 and b4 integrins. Opin. Gene Dev.  7:672-682.
  60. 1997 Lo, S. H., Yu, Q. C., Degenstein, L., Chen, L. B., and Fuchs, E.  Progressive kidney degeneration in mice lacking tensin. J Cell Biol.  136:1349-1361.
  61. 1996 Auger, K. R., Songyang, Z., Lo, S. H., Roberts, T. M., Chen, L. B.  Platelet-derived growth factor-induced formation of tensin and phosphoinositide 3-kinase complexes. J Biol. Chem.  271:23452-23457.
  62. 1995 Salgia, R., Brunkhorst, B., Pisick, E., Li, J. L., Lo, S. H., Chen, L. B., and Griffin, J. D.  Increased tyrosine phosphorylation of focal adhesion proteins in myeloid cell lines expressing p210BCR/ABL. Oncogene  11:1149-1155.
  63. 1995 Salgia, R., Li, J. L., Lo, S. H., Brunkhorst, B., Kansas, G. S., Sobhany, E., Sun, Y., Pisick, E., Hallek, M., Ernst, T., Tantravahi, R., Chen, L. B. and Griffin, J. D.  Molecular cloning of human paxillin, a focal adhesion protein phosphorylated by p210BCR/ABL. J  Biol. Chem.  270:5039-5047.
  64. 1994 Lo, S. H., Weisbery, E., and Chen, L. B.  Tensin: a potential link between the cytoskeleton with signal transduction.  BioEssays  16:817-823.
  65. 1994 Lo, S. H., An, Q., Bao, S., Wong, W., Liu, Y., Janmey, P. A., Hartwig, J. H., and Chen, L. B.  Molecular cloning of chick cardiac muscle tensin: full-length cDNA sequences, expressions and characterizations. J  Biol. Chem.  269:22310-22319.
  66. 1994 Lo, S. H., Janmey, P. A., Hartwig, J. H. and Chen, L. B.  Interactions of SH2 domain-containing tensin with actin and identification of its actin-binding domains. J Cell Biol.  125:1067-1075.
  67. 1994 Lo, S. H. and Chen, L. B.  Focal adhesion as a signal transduction organelle.  Cancer and Metastasis Reviews  13:9-24.
  68. 1991 Davis, S., Lu, M., Lo, S. H., Lin, S., Butler, J., Druker, B., Roberts, T., An, Q., and Chen, L. B. Presence of an SH2 domain in the actin-binding protein tensin.  Science  252:712-715.

其他著作

  • 上版日期：2025-01-03

close

Copyright © 2020 國立臺灣大學 生命科學院 生化科技學系

電話：+886-2-3366-2280

Fax：+886-2-3366-2271

mail：ntubst@ntu.edu.tw

地址 : 10617 臺北市羅斯福路四段一號 國立臺灣大學 生命科學院 生化科技學系

Department of Biochemical Science & Technology, National Taiwan University,

No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan (R.O.C.)

下方連結

更新日期

2025-03-27