1.Young T, Palta M, Dempsey J, et al: The occurrence of sleep-disordered breathing among middle-aged adults. The new England Journal of Medicine 328:1230-1235, 1993.
2.Lyons MM, Bhatt NY, Pack AI, et al: Global burden of sleep-disordered breathing and its implications. Respirology 25:690-702, 2020.
3.Gulotta G, Iannella G, Vicini C, et al: Risk Factors for Obstructive Sleep Apnea Syndrome in Children: State of the Art. Int J Environ Res Public Health 16, 2019.
4.Lavie P, Herer P, Peled R, et al: Mortality in sleep apnea patients: a multivariate analysis of risk factors. Sleep 18:149-157, 1995.
5.Eckert DJ, White DP, Jordan AS, et al: Defining phenotypic causes of obstructive sleep apnea. Identification of novel therapeutic targets. Am J Respir Crit Care Med 188:996- 1004, 2013.
6.Wellman A, Eckert DJ, Jordan AS, et al: A method for measuring and modeling the physiological traits causing obstructive sleep apnea. J Appl Physiol (1985) 110:1627- 1637, 2011.
7.Gleadhill IC, Schwartz AR, Schubert N, et al: Upper airway collapsibility in snorers and in patients with obstructive hypopnea and apnea. Am Rev Respir Dis 143:1300-1303, 1991.
8.Eckert DJ, Owens RL, Kehlmann GB, et al: Eszopiclone increases the respiratory arousal threshold and lowers the apnoea/hypopnoea index in obstructive sleep apnoea patients with a low arousal threshold. Clin Sci (Lond) 120:505-514, 2011.
9.Younes M: Role of arousals in the pathogenesis of obstructive sleep apnea. Am J Respir Crit Care Med 169:623-633, 2004.
10. Younes M, Ostrowski M, Atkar R, et al: Mechanisms of breathing instability in patients with obstructive sleep apnea. J Appl Physiol (1985) 103:1929-1941, 2007.
11. Longobardo GS, Evangelisti CJ, Cherniack NS: Analysis of the interplay between neurochemical control of respiration and upper airway mechanics producing upper airway obstruction during sleep in humans. Exp Physiol 93:271-287, 2008.
12. Younes M: Role of respiratory control mechanisms in the pathogenesis of obstructive sleep disorders. J Appl Physiol (1985) 105:1389-1405, 2008.
13. Jordan AS, Wellman A, Heinzer RC, et al: Mechanisms used to restore ventilation after partial upper airway collapse during sleep in humans. Thorax 62:861-867, 2007.
14. Loewen AH, Ostrowski M, Laprairie J, et al: Response of genioglossus muscle to increasing chemical drive in sleeping obstructive apnea patients. Sleep 34:1061-1073, 2011.
15. Younes M, Ostrowski M, Thompson W, et al: Chemical control stability in patients with obstructive sleep apnea. Am J Respir Crit Care Med 163:1181-1190, 2001.
16. Wellman A, Jordan AS, Malhotra A, et al: Ventilatory control and airway anatomy in obstructive sleep apnea. Am J Respir Crit Care Med 170:1225-1232, 2004.
17. Roland PS, Rosenfeld RM, Brooks LJ, et al: Clinical practice guideline: Polysomnography for sleep-disordered breathing prior to tonsillectomy in children. Otolaryngol Head Neck Surg 145:S1-15, 2011.
18. Gottlieb DJ, Punjabi NM: Diagnosis and Management of Obstructive Sleep Apnea: A Review. JAMA 323:1389-1400, 2020.
19. Yu JL, Afolabi-Brown O: Updates on management of pediatric obstructive sleep apnea. Pediatr Investig 3:228-235, 2019.
20. Sullivan CE, Issa FG, Berthon-Jones M, et al: Reversal of obstructive sleep apnoea by continuous positive airway pressure applied through the nares. Lancet 1:862-865, 1981.
21. Marin JM, Carrizo SJ, Vicente E, et al: Long-term cardiovascular outcomes in men with obstructive sleep apnoea-hypopnoea with or without treatment with continuous positive airway pressure: an observational study. Lancet 365:1046-1053, 2005.
22. Zozula R, Rosen R: Compliance with continuous positive airway pressure therapy: assessing and improving treatment outcomes. Curr Opin Pulm Med 7:391-398, 2001.
23. Randerath W, Verbraecken J, de Raaff CAL, et al: European Respiratory Society guideline on non-CPAP therapies for obstructive sleep apnoea. Eur Respir Rev 30, 2021.
24. Romero-Corral A, Caples SM, Lopez-Jimenez F, et al: Interactions between obesity and obstructive sleep apnea: implications for treatment. Chest 137:711-719, 2010.
25. Zong S, Du P, Li H, et al: Advances in animal models of obstructive sleep apnea. Front Med (Lausanne) 10:988752, 2023.
26. Brennick MJ, Kuna ST, Pickup S, et al: Respiratory modulation of the pharyngeal airway in lean and obese mice. Respir Physiol Neurobiol 175:296-302, 2011.
27. Baum DM, Morales Rodriguez B, Attali V, et al: New Zealand Obese Mice as a Translational Model of Obesity-related Obstructive Sleep Apnea Syndrome. Am J Respir Crit Care Med 198:1336-1339, 2018.
28. Kimoff RJ, Makino H, Horner RL, et al: Canine model of obstructive sleep apnea: model description and preliminary application. J Appl Physiol (1985) 76:1810-1817, 1994.
29. Hendricks JC, Kline LR, Kovalski RJ, et al: The English bulldog: a natural model of sleep-disordered breathing. J Appl Physiol 63:1344-1350, 1987.
30. Veasey SC, Chachkes J, Fenik P, et al: The effects of ondansetron on sleep-disordered breathing in the English bulldog. Sleep 24:155-160, 2001.
31. Veasey SC, Fenik P, Panckeri K, et al: The effects of trazodone with L-tryptophan on sleep-disordered breathing in the English bulldog. American Journal of Respiratory and Critical Care Medicine 160:1659-1667, 1999.
32. Veasey SC: Serotonin agonists and antagonists in obstructive sleep apnea: therapeutic potential. Am J Respir Med 2:21-29, 2003.
33. Veasey SC, Panckeri KA, Hoffman EA, et al: The effects of serotonin antagonists in an animal model of sleep-disordered breathing. Am J Respir Crit Care Med 153, 1996.
34. Hendricks JC, Kovalski RJ, Kline LR: Phasic respiratory muscle patterns and sleep- disordered breathing during rapid eye movement sleep in the English bulldog. Am Rev Respir Dis 144:1112-1120, 1991.
35. Hendricks JC, Petrof BJ, Panckeri K, et al: Upper airway dilating muscle hyperactivity during non-rapid eye movement sleep in English bulldogs. Am Rev Respir Dis 148:185- 194, 1993.
36. Petrof BJ, Pack AI, Kelly AM, et al: Pharyngeal myopathy of loaded upper airway in dogs with sleep apnea. J Appl Physiol (1985) 76:1746-1752, 1994.
37. Panckeri KA, Schotland HM, Pack AI, et al: Modafinil decreases hypersomnolence in the English bulldog, a natural animal model of sleep-disordered breathing. Sleep 19:626- 631, 1996.
38. Packer RMAA, Tivers M: Strategies for the management and prevention of conformation-related respiratory disorders in brachycephalic dogs. Veterinary Medicine: Research and Reports:219-219, 2015.
39. Pohl S, Roedler FS, Oechtering GU: How does multilevel upper airway surgery influence the lives of dogs with severe brachycephaly? Results of a structured pre- and postoperative owner questionnaire. The Veterinary Journal 210:39-45, 2016.
40. Hinchliffe TA, Liu N-C, Ladlow J: Sleep-disordered breathing in the Cavalier King Charles spaniel: A case series. Vet Surg 48:497-504, 2019.
41. Hendricks JC: Brachycephalic airway syndrome. Vet Clin North Am Small Anim Pract 22:1145-1153, 1992.
42. Koch DA, Arnold S, Hubler M, et al: Brachycephalic syndrome in dogs. Vet Focus 25:4-10, 2003.
43. Roedler FS, Pohl S, Oechtering GU: How does severe brachycephaly affect dog's lives? Results of a structured preoperative owner questionnaire. Vet J 198:606-610, 2013.
44. Niinikoski I, Himanen SL, Tenhunen M, et al: Description of a novel method for detection of sleep-disordered breathing in brachycephalic dogs. J Vet Intern Med 37:1475-1481, 2023.
45. Mellema MS, Hoareau GL: Hypomagnesemia in brachycephalic dogs. J Vet Intern Med 28:1418-1423, 2014.
46. Hoareau G, Mellema M: Pro-coagulant thromboelastographic features in the bulldog. J Small Anim Pract 56:103-107, 2015.
47. Hoareau GL, Jourdan G, Mellema M, et al: Evaluation of Arterial Blood Gases and Arterial Blood Pressures in Brachycephalic Dogs. J Vet Intern Med, 2012.
48. Pevernagie DA, Gnidovec-Strazisar B, Grote L, et al: On the rise and fall of the apnea- hypopnea index: A historical review and critical appraisal. J Sleep Res 29:e13066, 2020.
49. Talavera J, Kirschvink N, Schuller S, et al: Evaluation of respiratory function by barometric whole-body plethysmography in healthy dogs. Vet J 172:67-77, 2006.
50. Rozanski EA, Hoffman AM: Lung Mechanics Using Plethysmography and Spirometry, in King LG (ed), Vol. St Louis, Saunders, 2004, pp 175-180.
51. Manens J, Bolognin M, Bernaerts F, et al: Effects of obesity on lung function and airway reactivity in healthy dogs. Vet J 193:217-221, 2012.
52. Lundblad LK, Irvin CG, Adler A, et al: A reevaluation of the validity of unrestrained plethysmography in mice. J Appl Physiol 93:1198-1207, 2002.
53. Liu NC, Sargan DR, Adams VJ, et al: Using whole-body barometric plethysmography to evaluate the effectiveness of upper airway surgery for brachycephalic obstructive airway syndrome in French bulldogs, Berlin, 2015, (available from
54. Lin CH, Lee JJ, Liu CH: Functional assessment of expiratory flow pattern in feline lower airway disease. J Feline Med Surg 16:616-622, 2013.
55. Kirschvink N, Leemans J, Delvaux F, et al: Non-invasive assessment of growth, gender and time of day related changes of respiratory pattern in healthy cats by use of barometric whole body plethysmography. Vet J 172:446-454, 2006.
56. Kirschvink N, Leemans J, Delvaux F, et al: Non-invasive assessment of airway
responsiveness in healthy and allergen-sensitised cats by use of barometric whole body plethysmography. Vet J 173:343-352, 2007.
57. Hoffman AM, Dhupa N, Cimetti L: Airway reactivity measured by barometric wholebody plethysmography in healthy cats. Am J Vet Res 60:1487-1492, 1999.
58. Hirt RA, Vondrakova K, de Arespacochaga AG, et al: Effects of cadmium chloride inhalation on airflow limitation to histamine, carbachol and adenosine 5'-monophosphate assessed by barometric whole body plethysmography in healthy dogs. Vet J 173:62-72, 2007.
59. Hirt RA, Leinker S, Mosing M, et al: Comparison