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Faculty & Research >Faculty Profiles >Dr. Shen, Tang-Long
Faculty Profiles
 

Dr. Shen, Tang-Long

Title : Associate Professor
Highest degree : PhD. Molecular Medicine, Cornell University, USA
Specialties : Molecular Biology, Cell Biology
E-mail : shentl@ntu.edu.tw
Office : Room 315, The First Hall
Telephone : 886-2-3366-4998 (Office)¡@886-2-3366-4602 (Lab)
FAX : 886-2-2363-6490

Cell Biology Laboratory

Positions

08/11-present

Associate research fellow, Center for Biotechnology, National Taiwan University Taipei, Taiwan
08/11-present Associate Professor, Dept. of Plant Pathology and Microbiology, National Taiwan University
09/09-08/11 Assistant research fellow, Center for Biotechnology, National Taiwan University Taipei, Taiwan

08/04~08/11

Assistant Professor, Dept. of Plant Pathology and Microbiology, National Taiwan University
07/03-10/04 Postdoc. Fellow, American Heart Association
01/03-06/03 Research Associate, Cornell University, USA
07/96-07/97 Research Assistant, Int. of Molecular Medicine, National Taiwan University
07/91-96/92 Research Assistant, Dept. of Plant Pathology and Entomology, National Taiwan University
 

Honors and Awards

2001 The Society of Chinese Bioscientists in America (SCBA) 9th meeting Travel Awards and Fellowship.
2001 The American Society for Cell Biology (ASCB) 2001 annual meeting Predoctoral Travel Awards.
2002 Liu Memorial Award in Cornell University for an excellent progress in graduate program and high potential for a successful academic career.
2003-2005 American Heart Association postdoctoral fellowship.
 

Research Interests

  1. Cell biology (sub: cell migration, proliferation, and development)
  2. Signal transduction (sub: integrin and growth factor signaling)
  3. Cancer biology (sub: Breast and GI related cancers)
  4. Molecular Plant-Microbe Interactions (sub: RNA silencing and viroid)
 

Lab Members

Yu-Ling Tai phD Student Activation of FAK by integrin £]4 in an EGFR/Src dependent manner in tumor progression
Yun-Ting Tsou Master student
Chih-Hsu Lin Master student Development of an integrative diagnostic protocol for Citrus exocortis viroid (CEVd) and study of the viroid-host interactions that result in distinguishable symptoms
   
 

Publications
  1. DongCho Han, Tang-Long Shen , and Jun-Lin Guan (2000) Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J Biol. Chem. 275 (37): 28911-28917 ?
  2. Tang-Long Shen and Jun-Lin Guan (2001) Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett. 499 (1-2): 176-81?
  3. DongCho Han, Tang-Long Shen , and Jun-Lin Guan (2001) The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 20 (44): 6315-21
  4. Silvia M. Goicoechea, Yizeng Tu, Yun Hua, Ka Chen, Tang-Long Shen , Jun-Lin Guan, and Chuanyue Wu. (2002) Nck-2 interacts with focal adhesion kinase and modulates cell motility. Int. J Biochem. & Cell Biol.34: 791-805
  5. Tang-Long Shen , DongCho Han, and Jun-Lin Guan. (2002) The association of Grb7 with phosphoinositides regulates cell migration. J Biol Chem. 277 (32):29069-77
  6. DongCho Han*, Tang-Long Shen* , Hui Miao, Bingcheng Wang, and Jun-Lin Guan. (2002) EphBI associates with Grb7 and regulates cell migration. J. Biol. Chem. 277 (47): 45655-45661. (* equal contribution)
  7. Lee Ann Cooper*, Tang-Long Shen* and Jun-Lin Guan. (2003) Regulation of Focal Adhesion Kinase by its Amino-Terminal Domain through an Autoinhibitory Interaction. Mol. Cell. Biol. 23(22):8030-8041. (* equal contribution)
  8. Tang-Long Shen and Jun-Lin Guan. (2004) Grb7 in intracellular signaling and its role in cell regulation. Frontiers in Bioscience 9, 192-200?
  9. Peng, X., Ueda, H., Zhou, H., Stokol, T., Shen, T.-L ., Alcaraz, A., Nagy, T., Vassalli, J.-D., and Guan, J.-L. (2004). Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovascular Research 64 , 421-430
  10. Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen , Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong & Kun-Liang Guan (2004) Activation of FAK and Src are receptor-proximal events required for netrin signaling . Nature Neuroscience 7, 1213 - 1221
  11. Hui Miao, Klaus Strebhardt, Elena B. Pasquale, Tang-Long Shen , Jun-Lin Guan, and Bingcheng Wang (2005) Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: Role of Rho family small GTPases. J. Biol. Chem. 280(2):923-32 ?
  12. Tang-Long Shen , Ann Y.-J. Park, Ana Alcaraz, Xu Peng, Ihnkyung Jang, Pandelakis Koni, Richard A. Flavell, Hua Gu and Jun-Lin Guan (2005) Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 169(6):941-52
  13. Xu Peng, Marc S. Kraus, Huijun Wei, Tang-Long Shen, Romain Pariaut, Ana Alcaraz, Guangju Ji, Lihong Cheng, Qinglin Yang, Michael I. Kotlikoff, Ju Chen, Kenneth Chien, Hua Gu and Jun-Lin Guan (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes cardiac eccentric hypertrophy and fibrosis in mice. J. Clinical Investigation 116(1):217-27?
  14. Huang MC¡¯, Chen HY, Huang HC, Huang J, Shen TL, Lin NY, Liang JT, Ho CC, Cho IM, Hsu SM. (2006) Mucin-type core 2 £]-1,6-N-acetylglucosaminyltransferase is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene 25(23):3267-76 (*corresponding author)
  15. Huang MC. (2008) Ammonium hydroxide extracts from black tea inhibit growth, migration, and invasion of colon cancer cells. Journal of Food Biochemistry 32:201-215
  16. John Huang, Jin-Tung Liang, Hsiu-Chin Huang, Tang-Long Shen, Hsiao-Yu Chen, Neng-Yu Lin, Mei-Ieng Che, Wei-Chou Lin, Min-Chuan Huang (2007) £]1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. Molecular Cancer Research 5(6):543-52. ?
  17. Tamas Nagy, Huijun Wei, Tang-Long Shen, Xu Peng, Chun-Chi Liang, Boyi Gan, and Jun-Lin Guan. (2007) Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland J. Biol. Chem. 282(43):31766-76?
  18. SM Weis, S-T Lim, KM Lutu-Fuga, LA Barnes, X.L. Chen, J.R. Gothert, T-L Shen, J-L Guan, DD Schlaepfer, DA Cheresh (2008). Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK J. Cell Biol. 181(1):43-50. 10.257
  19. Ann Y.J. Park, Tang-Long Shen, Shu Chien and Jun-Lin Guan (2009) Role of focal adhesion kinase S732 phosphorylation in centrosome function during mitosis J. Biol. Chem. 284(14):9418-25
  20. Pei-Yu Chu, Ling-Ya Huang, Hsiao-Hsin Chen, Chun-Hua Hsu, Chun-Chi Liang, Jun-Lin Guan, Ting-Hsuan Hung, Tang-Long Shen* (2009) Tyrosine phosphorylation of Grb7 by FAK in the regulation of cell migration, proliferation and tumorigenesis J. Biol. Chem. 284(30):20215-26
  21. Bor-Sheng Ko, Tzu-Ching Chang, Chien-Hung Chen, Chia-Chia Liu, Shu-Man Liang, En-Wei Hsing, Cheng-Chin Kuo, Chiun Hsu, Ying-Chun Shen, Tang-Long Shen, Song-Kun Shyue, Vita M. Golubovskaya, Chung-Che Chang and Jun-Yang Liou (2009) Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B Life Science 86(5-6):199-206
  22. Y. H. Yu, S. C. Wu, W. T. K. Cheng, H. J. Mersmann, T. L. Shen* and S. T. Ding* (2010)The function of porcine PPAR£^ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes (* co-corresponding author; accepted)
  23. Chen HH, Chen CW, Chang YY, Shen TL, Hsu CH.(2010) Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide Acta Crystallogr Sect F Struct Biol Cryst Commun.66(Pt 2):195-7.
  24. Chun-Jiun Yang, Chi-Fon Chang*, Lin-Ya Huang, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu*. (2010) Resonance assignments of human C35 (C17orf37) protein, a novel tumor biomarker. Biomol. NMR Assign.4(2):191-3
  25. Jia-Rong Fan, Ting-Hsiang Huang, Chen-Yu Wen, Tang-Long Shen* and Tsai-Kun Li* (2010) Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses. European Journal of Pharmacology 638(1-3):13-20 (*correspondence; accepted)
  26. Chung-Yao Yang, Lin-Ya Huang, Tang-Long Shen*, J. Andrew Yeh* (2010) Cell adhesion, morphology and biochemistry on nano-topographic oxidized silicon surfaces e Cells and Materials 20:415-430 (* co-corresponding author)
  27. I-Rue Lai, Pei-Yu Chu, Hsiao-Sheng Lin, Jun-Yang Liou, Yee-Jee Jan, Jen-Chieh Lee, Tang-Long Shen* (2010) Autophosphorylation of Tyr-397 of focal adhesion kinase in gastric carcinoma and its clinical significance. American Journal of Pathology 177(4):1629-37 (This article is highlighted by Nature Reviews Gastroenterology and Hepatology 7, 592)
  28. Pei-Yu Chu, Tsia-Kun Li, Shih-Torng Ding, I-Rue Lai, Tang-Long Shen* (2010) EGF-induced Grb7 activation promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. Journal Biological Chemistry 285(38):29279-85
  29. Bor-Sheng Ko, Tzu-Ching Chang, Chiun Hsu, Chia-Chia Liu, Chien-Hung Chen, Yao-Chang Chen, Tang-Long Shen, Shyh-Chang Chen, JohnWang, Kenneth K. Wu, Yee-Jee Jan, Jun-Yang Liou (2010) 14-3-3£` protein overexpression and liver cancer metastasis and survival. Histopathology 58(5):705-11
  30. Liu TA, Jan YJ, Ko BS, Chen SC, Liang SM, Hung YL, Hsu C, Shen TL, Lee YM, Chen PF, Wang J, Shyue SK, Liou JY. (2011) Increased expression of 14-3-3£] promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma. American Journal of Pathology 179(6):2698-708.
  31. Lih Ru Liu, Shau Ping Lin, Chih-chien Chen, Yu Jen Chen , Chen Chen Tai, ShihChung Chang, Rong Huay Juang , Yi Wen Tseng, Bing Hsien Liu, Harry J. Mersamm, Tang Long Shen*, and Shih Torng Ding* (2011) Serum amyloid A induces lipolysis by down-regulating perilipin through ERK1/2 and PKA signaling pathways.Obesity 19(12):2301-9. (co-corresponding author)
  32. Li-Ya Wang, Shih-Shun Lin, Ting-Hsuan Hung, Tsai-Kun Li, Nai-Chun, Lin, Tang-Long Shen* (2012) Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing. Microbe-Plant Molecular Interactions 25(5):648-57.
  33. Yang CY, Liao TC, Shuai HH, Shen TL*, Yeh JA, Cheng CM (2012) Micropatterning of mammalian cells on inorganic-based nanosponges. Biomaterials 33(20):4988-97 (co-corresponding author)
  34. Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3£m Regulates £]-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3£]. PLoS ONE. 2012;7(6):e40193.
  35. Lin CE, Chen SU, Lin CC, Chang CH, Lin YC, Tai YL, Shen TL, Lee H (2012) Lysophosphatidic Acid Enhances Vascular Endothelial Growth Factor-C Expression in Human Prostate Cancer PC-3 Cells. PLoS One. 2012;7(7):e41096.
  36. Yang Y, Chou HY, Shen TL, Chang WJ, Tai PH, Li TK (2013) Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis. Antioxid Redox Signal. 18(10):1129-40
  37. Chun-Hua Hsu, Tang-Long Shen, Chi-Fon Chang, Yu-Yung Chang, Lin-Ya Huang (2012) Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-Like Fold with a Redox-Active Motif. PLoS ONE 7(12): e52292
  38. Wen-Ling Yao, Bor-Sheng Ko,Tzu-An Liu, Shu-Man Liang, Chia-Chia Liu, Yi-Jhu Lu, Shean-Shong Tzean, Tang-Long Shen*, and Jun-Yang Liou (2014) Cordycepin suppresses integrin/FAK signaling and EMT in hepatocellular carcinoma. Anti-Cancer Agents in Medicinal Chemistry;14(1):29-34. (Co-corresponding authors)
  39. Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D (2013) Conditional deletion of FAK in mice endothelium disrupts lung vascular integrity due to destabilization of RhoA and Rac1 activities. American Journal of Physiology - Lung Cellular and Molecular Physiology 305(4):L291-300.
  40. Bor-Sheng Ko, Yi-Jhu Lu, Wen-Ling Yao, Tzu-An Liu, Shean-Shong Tzean, Tang-Long Shen, Jun-Yang Liou (2013) Cordycepin regulates GSK3b/b-catenin signaling in human leukemia cells. Plos ONE 8(9):e76320
  41. Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK (2014) DNA Topoisomerase III Alpha Regulates p53-Mediated Tumor Suppression Clin Cancer Res. 20(6):1489-501
  42. Shang-Min Chou, Wan-Jung Lai, Tzu-Wen Hong, Jui-Ya Lai, Sheng-Hong Tsai, Yen-Hsun Chen, Sz -Hsien Yu, Cheng-Hsiang Kao, Richard Chu, Shih-Torng Ding, Tsai-Kun Li and Tang-Long Shen* (2014) Synergistic property of Cordycepin incultivated Cordyceps militaris-mediated apoptosis in human leukemia cells Phytomedicine 21 (12): 1516¡V1524
  43. Chun-Yi Lin, Meng-Ling Wu, Tang-Long Shen, Hsin-Hung Yeh and Ting-Hsuan Hung (2015) Development of molecular detection system and field investigation for two citrus viroids in Taiwan. Virology Journal 12(1):11.
  44. Yu-Lin Tai, Lih-Charng Chen, Tang-Long Shen* (2015) Emerging roles of focal adhesion kinase in cancer. BioMed Research International: 2015:690690. Epub 2015 Mar 31
  45. Yu-Ling Tai, Pei-Yu Chu, I-Rui Lai, Hui-Yuan Tseng, Jun-Yang Liou, Jun-Lin Guan, Tang-Long Shen* (2015) An EGFR/Src-dependent b4 Integrin/FAK complex contributes to the malignancy of breast cancer. Scientific Reports 5, 16408; doi: 10.1038/srep16408
  46. Yen-Wen Wang, Tzu-Wen Hong, Yu-Ling Tai, Ying-Jing Wang, Sheng-Hong Tsai, Pham Thi Kim Lien, Tzu-Ho Chou, Jui-Ya Lai, Richard Chu, Shih-Torng Ding, Kenji Irie, Tsai-Kun Li, Shean-Shong Tzean and Tang-Long Shen* (2015) Evaluation of an epitypified Ophiocordyceps formosana (Cordyceps s.l.) for its pharmacological potential. Evidence-based complementary and alternative medicine Volume 2015, Article ID 189891
  47. Shang-Min Chou, Wan-Jung Lai, Tzuwen Hong, Sheng-Hong Tsai, Yen-Hsun Chen, Cheng-Hsiang Kao, Richard Chu, Tang-Long Shen* and Tsai-Kun Li* (2015) Involvement of p38 MAPK in the anticancer activity of cultivated Cordyceps militaris. The American Journal of Chinese Medicine 43(5):1043-1057 (co-corresponding author)
  48. Bruno Costa-Silva, Nicole M. Aiello, Swarnima Singh, Haiying Zhang, Basant Kumar Thakur, Annette Becker, Ayuko Hoshino, Milica Te?i? Mark, Henrik Molina, Jenny Xiang, Tuo Zhang, Till-Martin Theilen, Guillermo Garcia-Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, Goncalo Rodrigues, Tang-Long Shen, Knut Jorgen Labori, Inger Marie Bowitz Lothe, Elin H. Kure, Allyson J. Ocean, Jonathan Hernandez, Alexandre Doussot, Saya Ebbesen, Paul Grandgenett, Michael Hollingsworth, Maneesh Jain, Kavita Mallya, Surinder Batra, William R. Jarnagin, Robert E. Schwartz, Irina Matei, Hector Peinado, Ben Stanger, Jacqueline Bromberg, and David Lyden (2015) Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biol. 17(6):816-26.
  49. Ayuko Hoshino*, Bruno Costa-Silva*, Tang-Long Shen*, Goncalo Rodrigues, Ayako Hashimoto, Milica Tesic Mark, Henrik Molina, Shinji Kosaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay Pharmer, Tari King, Linda Bojmar, Alexander E. Davies,Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, Kimberly Kramer, Leonard H. Wexlex, Aru Narendran, Gary K. Schwartz. John H. Healey, Per Sandstrom, Knut Jorgen Labori, Elin H. Kure, Kavita Mallya, Surinder K. Batra, Rajesekhar K. Vinagolu, Oystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Hector Peinado, Jacqueline Bromberg, David Lyden (2015) Tumor exosome integrins determine organotropic metastasis. Nature 527(7578):329-35 (*co-first authors)
  50. Chun-Yi Lin, Meng-Ling Wu, Tang-Long Shen, Ting-Hsuan Hung (2015) A mutual titer-enhancing relationship and similar localization patterns between Citrus exocortis viroid and Hop stunt viroid co-infecting two citrus cultivara Virology Journal 12(1):142
  51. Han-Lin Liu, Yang-Wei Liu, Tang-Long Shen, Chun-Hua Hsu and Ya-Chun Chang (2015) Characterization and application of a common epitope recognized by a broad-spectrum C4 monoclonal antibody against capsid proteins of plant potyviruses. Applied Microbiology and Biotechnology DOI 10.1007/s00253-015-7116-x
  52. Yu-Ling Tai, I-Rue Lai, Yu-Ju Peng, Shih-Torng Ding, Tang-Long Shen* Activation of focal adhesion kinase through an interaction with £]4 integrin contributes to colon cancer progression. FEBS letters (under revision)
  53. Yu-Ling Tai, Li-Hsuan Tung, Yu-Chi Lin, Pei-Jung Lu, Tang-Long Shen (2015) Pin1 negatively regulated Grb7 protein stability via the ubiquitin-proteosome pathway requires the cis-trans isomerase activity of Pin1. PLoS One (under revision)
  54. Daniela Gwiazdowska , Katarzyna Staszak , Dr. Ying-Lien Chen , Tang-Lon Shen (2015) Surface and antimicrobial activity of sulfobetaines (submitted)
  55. Pei-Yu Chu, Yu-Ling Tai, Tang-Long Shen* (2015) Transcriptional up-regulation of EphA4 by EGF-Grb7-Stat3 signaling promotes lung cancer progression. (in preparation)
  56. Chao-Wei Huang, Tzu-Wen Hong, Ying-Jing Wang, Ju-Chun Pe, Wen-Sung Lai, Shih-Torng Ding, and Tang-Long Shen* (2015) Ophiocordyceps formosana extract improves hyperglycemia and depression in an STZ-induced mouse model (submitted)
  57. Tang-Long Shen*, Lin-Ya Huang, Yun-Ting Tsou, Hsin-Jung Wu, Chun-Hua Hsu, Jun-Lin Guan* (2015) Activation of focal adhesion kinase through its FERM domain-mediated interaction with D3-phosphoinositides (in preparation)
 
Last Updated October 27 ,2010
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Phone: 886-2-3366-4603 Fax: 886-2-2363-6490
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