Dr. Shen, Wei-Chiang Title : Professor Highest degree : PhD. Plant Pathology and Microbiology, Texas A&M University, USA Specialties : Fungal Genetics, Physiology, Molecular Biology E-mail : wcshen@ntu.edu.tw Office : Room 216, The First Hall Telephone : 886-2-3366-4599 FAX : 886-2-2363-6490 Fungal Physiology and Molecular Biology Laboratory

Positions

2011-Present	Professor, Dept. of Plant Pathology and Microbiology, National Taiwan University
2005-2011	Associate Professor, Dept. of Plant Pathology and Microbiology, National Taiwan University
2000-2005	Assistant Professor, Dept. of Plant Pathology and Microbiology, National Taiwan University
1999-2000	Postdoctoral research fellow, Dept. of Genetics, Medical Center Duke University North Carolina, USA
1993-1999	Graduate Research Assistant, Dept. of Plant Pathology and Microbiology, Texas A&M University College Station, Texas, USA
1991-1993	Research Assistant Institute of Molecular Biology, Academia Sinica, Nankang, Taipei, Taiwan
1989-1991	Graduate Research Assistant, Dept. of Plant Pathology and Entomology National Taiwan University, Taiwan

Honors and Awards

Research Interests

1. Molecular dissection of signal transduction pathways regulating mating, filamentous growth, and virulence in human pathogenic fungus, Cryptococcus neoformans
2. Study of the molecular mechanisms regulating the pathogenesis in plant pathogenic fungi
3. Characterization of the biosynthetic pathway of bioactive polysaccharides in Ganoderma lucidum
4. Development of transformation and expression systems in Ganoderma lucidum
5. Development of the novel control technique for guava Myxosporium wilt

Lab Members

1. Yeh, Y.L., Lin, Y.S., Su, B.J., Shen, W.C. 2008. A screening for suppressor mutants reveals components involved in the blue light-inhibited sexual filamentation in Cryptococcus neoformans. Fungal Genetics and Biology (in press).
2. Lu, Y. K., K. H. Sun, and W. C. Shen*. 2005. Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans. Molecular Microbiology 56:480-491. (SCI, Impact Factor 5.959)
3. Schroers, H.-J., M. M. Geldenhuis, M. J. Wingfield, M. H. Schoeman, Y.-F. Yen, W.-C. Shen, and B. D. Wingfield. 2005. Classification of the guava wilt fungus Myxosporium psidii, the palm pathogen Gliocladium vermoesenii and the persimmon wilt fungus Acremonium diospyri in Nalanthamala. Mycologia 97: 375-395. (SCI, Impact Factor 1.433)
4. Hsueh, Y. P., and W. C. Shen*. 2005. A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans. Eukaryotic cell 4:147-155. (SCI, Impact Factor 3.954)
5. Shen, W. C. , R. C. Davidson, G. M. Cox, and J. Heitman. 2002. Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryotic cell 1: 366-377.
6. Lengeler, K. B., R. C. Davidson, C. D'soura, Harashima T., W.-C. Shen , P. Wang, X. Pan, M. Waugh, and J. Heitman. 2000. Signal transduction cascades regulating fungal development and virulence. Microbiology and Molecular Biology Reviews 64 (4): 746-785
7. Shen, W. C. , P. Bobrowicz, and D. J. Ebbole. 1999. Isolation of pheromone precursor genes of Magnaporthe grisea. Fungal Genetics and Biology 27: 253-263.
8. Shen, W. C. 1999. Cloning and characterization of a pheromone precursor gene of Magnaporthe grisea. Ph D Dissertation. Texas A&M University. 86pp.
9. Shen, W. C. , J. Wieser, T. Adams, and D. J. Ebbole. 1998. The Neurospora rca-1 gene complements an Aspergillus flbD sporulation mutant but has no identifiable role in Neurospora sporulation. Genetics 148: 1031-1041.
10. Shen, W. C. , and D. J. Ebbole. 1997. Cross-pathway and pathway-specific control of amino acid biosynthesis in Magnaporthe grisea. Fungal Genetics and Biology 21: 40-49.
11. Shen, W. C. , and C. P. Lin. 1994. Application of immunofluorescent staining and tissue-blotting techniques for the detection of a mycoplasmalike organism associated with sweetpotaot witches' broom. Plant Pathol. Bull. 3(2): 79-83.
12. Shen, W. C. , and C. P. Lin. 1993. Production of monoclonal antibodies against a mycoplasmalike organism associated with sweet potato witches' broom. Phytopathology 83: 671-675.
13. Lin, C. P., W. C. Shen , H. C. Ko, F. L. Chang, Y. L. Yu, M. F. Chen, and F. Y. Wu. 1993. Application of monoclonal antibodies and cloned DNA probes for detection and differentiation of phytopathogenic mycoplasmalike organism. Plant Pathol. Bull. 2(3): 161-168.
14. Chao, Y. C., H. A. Wood, C. Y. Chang, H. J. Lee, W. C. Shen , and H. T. Lee. 1992. Differential Expression of Hz-1 baculovirus genes during productive and persistent viral infection. J. Virol. 66: 1442-1448.
15. Shen, W. C. , and C. P. Lin. 1992. Development and application of monoclonal antibodies against the mycoplasmalike organism (MLO) associated with sweet potato witches' broom. Master thesis, Natl. Taiwan Univ. 98pp.
16. Yeh, Y. L., Y. S. Lin, B. J. Su, and W. C. Shen*. 2009. A screening for suppressor mutants reveals components involved in the blue light-inhibited sexual filamentation in Cryptococcus neoformans. Fungal Genet. Biol. 46:42-54. (SCI)
17. Huang, J. Y., H. T. Hu, and W. C. Shen*. 2009. Phylogenetic study of two truffles, Tuber formosanum and T. furfuraceum, identified from Taiwan. FEMS Microbiology Letters 294:157-171. (SCI)