Chung-Liang Chien's Home Page

Publications (2011- 2020)
  1. Chen SY, Chiu LY, Maa MC, Wang JS, Chien CL, Lin WW. zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy. 2011; 7(2):217-28.
  2. Tseng KW, Peng ML, Wen YC, Liu KJ and Chien CL*. Neuronal degeneration in autonomic nervous system of dystonia musculorum mice. J Biomed Sci. 2011; 18:9.
  3. Huang HP, Chen PH, Hwu WL, Chuang CY, Chien YH, Stone L, Chien CL, Li LT, Chiang SC, Chen HF, Ho HN, Chen CH, Kuo HC*. Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum Mol Genet. 2011; 20(24):4851-64.
  4. Lee WC, Chen YY, Kan D, Chien CL*. A neuronal death model: Overexpression of neuronal intermediate filament protein peripherin in PC12 cells. J Biomed Sci. 2012; 19:8. doi:10.1186/1423-0127-19-8.
  5. Lee WC, Kan D, Chen YY, Han SK, Lu KS, Chien CL*. Suppression of extensive neurofilament phosphorylation rescues α-internexin/peripherin-overexpressing PC12 cells from neuronal cell death. PLoS One. 2012; 7(8):e43883. doi:10.1371.
  6. Chen YT, Tsai MS, Yang TL, Ku AT, Huang KH, Huang CY, Chou FJ, Fan HH, Hong JB, Yen ST, Wang WL, Lin CC, Hsu YC, Su KY, Su IC, Jang CW, Behringer RR, Favaro R, Nicolis SK, Chien CL, Lin SW*, Yu IS*. R26R-GR: A cre-activable dual fluorescent protein reporter mouse. PLoS One. 2012; 7(9):e46171.
  7. Chen YL, Chang MC, Chen CA, Lin HW, Cheng WF*, Chien CL*. Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses. PLoS One. 2012; 7:e47190.
  8. Chen SJ, Tsai JC, Lin CY, Chang CK, Tseng TH, Chien CL*. Brain-derived neurotrophic factor-transfected and nontransfected 3T3 fibroblasts enhance migratory neuroblasts and functional restoration in mice with intracerebral hemorrhage . J Neuropathol Exp Neurol. 2012; 71:1123-1136.
  9. Peng ML, Tsai CY, Chien CL, Hsiao JCJ, Huang SY, Lee CJ, Lin HY, Wen YC and Tseng, KW*. The influence of low-powered family LED lighting on eyes in mice experimental model. Life Science Journal. 2012; 9:477-482.
  10. Liu CH, and Chien CL*. Molecular cloning and characterization of chicken neuronal intermediate filament protein α-internexin. J Comp Neurol. 2013; 521:2147-64.
  11. Liu CH, Wang IJ, Wei FD, Chien CL*.Neuronal intermediate filament α  - internexin is expressed by neuronal lineages in the developing chicken retina. Exp Eye Res. 2013; 110:18-25.
  12. Wang NK, Lai CC, Liu CH, Yeh LK, Chou CL, Kong J, Nagasaki T, Tsang S, and Chien CL*. Origin of fundus hyperautofluorescent (AF) spots, and their role in retinal degeneration in a mouse model of Goldmann-Favre Syndrome. Dis Model Mech. 2013; 6:1113-22. doi: 10.1242/dmm.012112.
  13. Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL* and Kuo HC*. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013; 41:7753-7770.
  14. Shen WC, Liang CJ, Wu VC, Wang SH, Young GH, Lai IR, Chien CL, Wang SM, Wu KD, Chen YL. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Stem Cells Dev. 2013; 22:1408-1418.
  15. Chen YL, Cheng WF, Chang MC, Lin HW, Huang CT, Chien CL* and Chen CA*. Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma. Gynecol Oncol. 2013; 131:63-68.
  16. Peng ML, Lee CJ, Chien CL, Liu CL, Tsai CY, Wen YC, Tseng KW*. Protective effects of (-)-epigallocatechin gallate on blue light-induced damage in retinoblastoma Y79 cells by activating estrogen receptor pathway. Life Science Journal, 2013; 10: 192-198.
  17. Chen HF, Jan PS, Kuo HC, Wu FC, Lan CW, Huang MC, Chien CL, Ho HN*. Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGFP expressing human embryonic stem cells.  Reprod Biomed Online. 2014; 05:009. doi: 10.1016/j.rbmo.
  18. Hong JH, Lee WC, Hsu YM, Liang HJ, Wan CH, Chien CL*, Lin CY*. Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics. J Appl Toxicol. 2014; 34(12):1379-1388
  19. Hou PS, Huang WC, Chiang W, Lin WC, Chien CL*. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced puripotent stem cells. Cell Reprogram. 2014;16:467-476. doi: 10.1089/cell.2014.0029.
  20. Hong JB, Chou FJ, Ku Amy T., Fan HH, Lee TL, Huang YH, Yang TL , Su IC, Yu IS, Lin SW, Chien CL, Ho HN, Chen YT*. A nucleolus-predominant piggybac transposase, NP-mPB, Mediates elevated transposition efficiency in mammalian cells. PLoS One. 2014; 9(2):e89396
  21. Chao CC, Kan D, Lu KS, Chien CL*. The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells. Stem Cell Res. 2015; 14(2):211-23. doi: 10.1016/j.scr.2015.01.008.
  22. Li YC, Chen SJ and Chien CL*. Erythropoietin produced by genetic-modified NIH/3T3 fibroblasts enhances the survival of degenerating neurons. Brain Behav. 2015; 5(8) (Cover), doi:10.1002/brb3.356.
  23. Chao CC, Kan D, Lo TH, Lu KS, Chien CL*.  Induction of neural differentiation in rat c6 glioma cells with taxol. Brain Behav. 2015; 5(12) (Cover), doi: 10.1002/brb3.414
  24. Liao ML, Peng WH, Kan D, Chien CL*. Developmental Pattern of the neuronal intermediated filament inaa in the zebrafish retina. J Comp Neurol. 2016; 524(18):3810-3826. doi:10.1002/cne.24033.
  25. Lee WD, Wang KC, Tsai YF, Chou PC, Tsai LK, Chien CL*. Subarachnoid Hemorrhage Promotes Proliferation, Differentiation, and Migration of Neural Stem Cells via BDNF Upregulation. PLoS One. 2016 Nov 10;11(11) : e0165460.
  26. Numpaisal PO, Rothrauff BB, Gottardi R, Chien CL, Tuan RS*. Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study. Connect Tissue Res. 2017;58(3-4):355-365.
  27. Pu CM, Liu CW, Liang CJ, Yen YH, Chen SH, Jiang-Shieh YF, Chien CL, Chen YC, Chen YL*. Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression. J Invest Dermatol. 2017 Jun;137(6):1353-1362.
  28. Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC*. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic Acids Res. 2017 Oct 13;45(18):10492-10503.
  29. Wong CW, Chen YT, Chien CL, Yu TY, Rwei SP, Hsu SH*. A simple and efficient feeder-free culture system to up-scale iPSCs on polymeric material surface for use in 3D bioprinting. Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:69-79.
  30. Hsin WC, Chang CH, Chang CY, Peng WH, Chien CL, Chang MF, Chang SC*. Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus. J Biomed Sci. 2018; 25(1):47.
  31. Liao ML, Peng WH, Kan D, Chien CL*. Distribution patterns of the zebrafish neuronal intermediate filaments inaa and inab. J Neuro Res. 2018; 00:1–13. doi: 10.1002/jnr.24347.
  32. Chou PC, Tsai YC, Chen SJ, Tsai LK*, Chien CL*. Intracerebral transplantation of erythropoietin‐producing fibroblasts facilitates neurogenesis and functional recovery in an ischemic stroke model. Brain Behav. 2019 ;e01274.doi: 10.1002/brb3.1274
  33. Wu A*, Kielstein H, Sakurai T, Noel G, Viranta-Kovanen S, Chien CL, Bernd P. Internationalization of medical education-building a program to prepare future leaders in healthcare. Med Sci Educ. 2019;29(2):535–47. (International Collaboration).
  34. Sun N.-Y.; Chen Y.-L.; Lin H.-W.; Chiang Y.-C.; Chang C.-F.; Tai Y.-J.; Chen C.-A.; Sun W.-Z.; Chien CL; Cheng W.-F. Immune checkpoint Ab enhances the antigen-specific anti-tumor effects by modulating both dendritic cells and regulatory T lymphocytes. Cancer Letters. 2019 vol 444 p20-34.
  35. Chen Y.-L.; Lin H.-W.; Chien CL.; Lai Y.-L.; Sun W.-Z.; Chen C.-A.; Cheng W.-F. BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes. Journal for ImmunoTherapy of Cancer. 2019 vol 7:1 p313.
  36. Shih J.-C.; Lin H.-H.; Hsiao A.-C.; Su Y.-T.; Tsai S.; Chien CL.; Kung H.-N. Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion. FASEB Journal. 2019 vol 33:5 p 6281-6295.
  37. Pu C.-M.; Chen Y.-C.; Chen Y.-C.; Lee T.-L.; Peng Y.-S.; Chen S.-H.; Yen Y.-H.; Chien CL; Hsieh J.-H.; Chen Y.-L. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps. Mediators of Inflammation. 2019 vol 2019 p 2343867.
  38. Wu A, Noel G, Wingate R, Kielstein H, Sakurai T, Viranta-KovanenS, Chien CL, Traxler H, Waschke J, Vielmuth F, Gill M, Kitahara S, Kato Y, Keay K, Olson J, Bernd P. An International Partnership of 12 Anatomy Departments – Improving Global Health through Internationalization of Medical Education. Annals of Global Health. 2020; 86(1): 27, 1–14.


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