Chung-Liang Chien's Home Page

Publications (1991-Present)
Publications (1991-2000):
  1. Chien, C.L., Y.P. Chau, and K.S. Lu. 1991. Ultrastructural studies on the barrier properties of the paraganglia in the rat recurrent laryngeal nerve. Acta Anat. 141:262-268.
  2. Chau, Y.P., C.L. Chien, and K.S. Lu. 1991. The permeability of capillaries among the small granule-containing cell in rat superior cervical ganglia: an ultrastructural lanthanum tracer study. Histol. Histopathol. 6:261-268.
  3. Lu, K.S., C.L. Chien, and Y.P. Chau. 1992. Effects of 5-hydroxydopamine and 6-hydroxydopamine on the ultrastructure of Type I cells in paraganglia of the rat recurrent laryngeal nerve. Arch. Histol. Cytol. 55:57-65.
  4.  Chien, C.L. and R.K.H. Liem. 1994. Characterization of the mouse gene encoding the neuronal intermediate filament protein, alpha-internexin. Gene 149:289-292.
  5. Chien, C.L. and R.K.H. Liem. 1995. The neuronal intermediate filament, alpha-internexin is transiently expressed in amacrine cells in the developing mouse retina. Exp. Eye Res. 61:749-756.
  6. Chien, C.L., C.A. Mason, and R.K.H. Liem. 1996. alpha-internexin is the only neuronal intermediate filament expressed in developing cerebellar granule neurons. J. Neurobiol. 29:304-318.
  7. Wang, S.M., T.H Fong, S.Y. Hsu, C.L. Chien and J.C. Wu. 1997. Reorganization of a novel vimentin-associated protein in 3T3-L1 cells during adipose conversion. J. Cellular Biochem. 67:84-91.
  8. Wei, H.J., T.H. Su, C.L. Chien, and C.R. Tzeng. 1997. Florescence in situ hybridization (FISH) as a method to detect aneuploid cells. Fetal Diagn. Ther. 12:309-313.
  9. Pekny M., C. Eliasson, C.L. Chien, L.G. Kindblom, R. Liem, A. Hamberger, and C. Betsholtz. 1998. GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density. Exp. Cell Res. 239:332-343.
  10. Ho, C.L., C.L. Chien, K. Brown, and R.K.H. Liem. 1998. Studies of carboxyl-terminal truncation mutants of the neuronal intermediate filament protein, peripherin. J. Neurochem. 70:1916-1924.
  11.  Chien, C.L.*, T.H. Lee, and K.S. Lu. 1998. The distribution of neuronal intermediate filament proteins in the developing mouse olfactory system. J. Neurosci. Res. 54:353-363.
  12. Ching, G.Y., C.L. Chien, R. Flores, and R.K.H. Liem. 1999. Overexpression of alpha-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice. J. Neurosci. 19:2974-2986.
  13. Shih S.C., C.L. Chien, K.W. Tseng, S.C. Lin, and C.R. Kao. 1999. Immunohistochemical studies of transforming growth factor-β and its receptors in the gastric mucosa of patients with refractory gastric ulcer. J. Formosan Medical Assoc. 98:613-620.
  14. Yang, M.F., C.L. Chien, and K.S. Lu. 1999. Morphological, immunohistochemical and quantitative studies of murine brain mast cells after mating. Brain Res. 846:30-39.

Publications (2001-2005)
  1. Chou HC, Chien CL, , Huang HL, and Lu KS. Effects of zinc deficiency on the vallate papillae and taste buds in rats. J. Formos. Med. Assoc. 2001; 100:326-335.
  2. Chou HC, Chien CL, and Lu KS. The distribution of PGP9.5, BDNF and NGF in the vallate papilla of adult and developing mice. Anat. Embryol. 2001; 204:161-169.
  3. Chien CL*, Wang P, Yin HS, Lue JH, Wu JC, Hsieh ST, and Lu KS. Evaluation of anatomy course from the students of allied health sciences. J. Med. Education 2001; 5:124-134.
  4. Yang MF, Chien CL, and Lu KS. Compound 48/80-induced degranulation of GnRH-like immunoreactive mast cells in the brain and mesentry of the gerbil. Zool. Stud. 2002; 41:99-110.
  5. Chien CL*, Chen TW, Lin YS, and Lu KS. The Apoptotic Process of Human Bladder Carcinoma T24 Cells Induced by Retinoid. J. Biomed. Sci. 2004; 11:631-640.
  6. Chen SC, Huang CC, Chien CL, Jeng CJ, Su HT, Chiang E, Liu MR, Wu CH, Chang CN, and Lin RH. Cross-linking of p-selectin glycoprotein ligand-1 induced death of activated T cells. Blood 2004; 104:3233-3242.
  7. Lee HH, Chien CL, Liao HK, Chen YJ, and Chang ZF. Nuclear efflux of heterogeneous nuclear ribonucleoprotein C1/C2 in apoptotic cells: a novel nuclear export dependent on Rho-associated kinase activation. J. Cell Sci. 2004; 117:5579-5589.
  8. Wang P, Yin HS, Lue JH, Wu JC, Hsieh ST, and Chien CL*. The evaluation of anatomy course provided for the nursing students. J. Med. Education 2004; 8:78-86
  9. Yang KT, Pan SF, Chien CL, Hsu SM, Tseng YZ, Wang SM, and Wu ML. Mitochondrial Na+ overload is caused by oxidative stress and leads to activation of the caspase 3- dependent apoptotic machinery. FASEB J. 2004; 18:1442-4.
  10. Shih SC, Tseng KW, Lin SC, Kao CR, and Chien CL*. Expression patterns of transforming growth factor-beta and its receptors in the gastric mucosa of patients with refractory gastric ulcer. World J. Gastroenterol. 2005; 11:136-141.
  11. Yu MF, Chien CL, Lee WT, and Yin HS. Effects of amphetamine on the AMPA-mediated synaptic activity and the expression of AMPA receptor subunit 2 of brain neurons. J. Mol. Neurosci. 2005; 25:171-181.
  12. Chien CL*, Liu TC, Ho CL, and Lu KS. Overexpression of neuronal intermediate filament protein internexin in PC 12 cells. J. Neurosci. Res. 2005; 80:693-706.
  13. Chien CL, Chen YC, Chang MF, Greenberg AS, and Wang SM. Magnolol induces the distribvutional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochem. Cell Biol. 2005; 123:429-439.
  14. Chiang PC, Chien CL, Pan SL, Chen WP, Teng CM, Shen YC, and Guh JH. Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. J. Hepatol. 2005; 43:679-686.
  15. Yen ML, Su JL, Chien CL, Tseng KW, Yang CY, Chen WF, Chang CC, and Kuo ML. Diosgenin induces HIF-1 activation and angiogenesis through estrogen receptor-related PI3K/Akt and p38 MAPK pathways in osteoblasts. Mol. Pharmacol. 2005; 68:1061-1073.
  16. Chien CL*, Lu KS, Lin YS, Hsieh CJ, and Hirokawa N. The functional Cooperation of MAP1A Heavy Chain and Light Chain 2 in the Binding of Microtubules. Exp. Cell Res. 2005; 308:446-458.
  17. Ko TL, Chien CL, and Lu KS. The expression of α-internexin and peripherin in the developing mouse pineal gland. J. Biomed. Sci. 2005; 12:777-789.
  18. Huang DM, Hung Y, Ko BS, Hsu SC, Chen WH, Chien CL, Tsai CP, Kuo CT, Kang JC, Yang CS, Mou CY, and Chen YC. Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. FASEB J. 2005; 19:2014-2016.

Publications (2006-2010)
  1. Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ, and Wu ML*. Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ. 2006; 13:1815-1826.
  2. Wang P, Wang SM, Hsieh CJ, and Chien CL*. Neural expression of α-internexin promoter in vitro and in vivo. J. Cell. Biochem. 2006; 97:275-287.
  3. Shih JC, Chien CL*, Ho HN, Lee WC, and Hsieh FJ. Stellate transformation of invasive trophoblast: A distinct phenotype of trophoblast that involves in decidual vascular remodeling and controlled invasion during pregnancy. Hum. Reprod. 2006; 21:1299-1304.
  4. Tseng KW, Lu KS, and Chien CL *. A possible cellular mechanism of neuronal loss in the dorsal root ganglia of dystonia musculorum (dt) mice. J. Neuropathol. Exp. Neurol. 2006; 65:336-347.
  5. Tseng WC, Lu KS, Lee WC, Chien CL*. Redistribution of GFAP and aB-crystallin after thermal stress in C6 glioma cell line. J. Biomed. Sci. 2006; 13:681-694.
  6. Chen SU, Chien CL, Wu MY, Chen TH, Lai SM, Lin CW, Yang YS*.. Novel direct cover vitrification (DCV) for cryopreservation of ovarian tissues increases follicle viability and pregnancy capability in mice models. Hum. Reprod. 2006; 21: 2794-2800.
  7. Chen HF, Kuo HC, Chien CL, Shun CT, Yao YL, Ip PL, Chuang CY, Wang CC, Yang YS, Ho HN*. Derivation, characterization and differentiation of human embryonic stem cells: comparing serum-containing versus serum-free media and evidences of germ cell differentiation. Hum. Reprod. 2007; 22:567-577.
  8. Kung HN, Chien CL, Chau GY, Don MJ, Lu KS, Chau YP*. Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of b-lapachone on endothelial cells in vitro. J. Cell. Physiol. 2007; 211:522-532.
  9. Yu CY, Chen JY, Lin YY, Shen KF, Lin WL, Chien CL, Ter Beest MB, Jou TS*. A bipartite signal regulates the faithful delivery of apical domain marker Podocalyxin/Gp135. Mol. Biol. Cell 2007; 18:1710-1722.
  10. Shyu MK, Yuan RH, Shih JC, Wu MZ, Chen HL, Kuo YC, Chien CL, Chow LP, Chen HL, Hsieh FJ. Kinetics and functional assay of liver repopulation after human cord blood transplantation. Dig Liver Dis. 2007; 39:455-465.
  11. Yeh LK, Liu CY, Chien CL, Converse RL, Kao WW, Chen MS, Hsieh FJ, Wang IJ*. Molecular analysis and characterization of zebrafish keratocan (zKera) gene. J Biol Chem. 2008; 283:506-517.
  12. Wang P. Jeng CJ, Chien CL, Wang SM*. Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons. Biochem Biophys Res Commun. 2008; 366:393-400.
  13. Tseng KW, Chau YP, Yang MF, Lu KS, and Chien CL*. Abnormal cellular translocation of α-Internexin in spinal motor neurons of dystonia musculorum mice. J. Comp. Neurol. 2008. 507:1053-1064.
  14. Wang SY, Chien CL, Shih SC*. Intercellular Invasion of Helicobacter pylori and Delayed Healing of a Gastric Ulcer. Am J Gastroenterol. 2008;103:249-250.
  15. Fang KM, Lee AS, Su MJ, Lin CL, Chien CL*, Wu ML*. Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovasc Res. 2008. 78:533-545.
  16. Thajeb P*, Wang P, Chien CL, Harrigan R. Novel polymorphisms of the amyloid precursor protein (APP) gene in Chinese/Taiwanese patients with Alzheimer’s disease. J Clin Neurosci. 2009;16:259-63.
  17. Chen TY, Chi KH, Wang JS, Chien CL, Lin WW*. Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses. Free Radic Biol Med. 2009; 46:643-655.
  18. Huang C, Chang SC, Yang HC, Chien CL and Chang MF*. Clathrin-mediated post-Golgi trafficking in the morphogenesis of hepatitis delta virus. J Virol. 2009; 83:12314-12324.
  19. Chen YT*, Furushima K, Hou PS, Ku AT, Deng JM, Jang CW, Fang H, Adams HP, Kuo ML, Ho HN, Chien CL*, and Behringer RR*. PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev. 2010; 19:763-771.
  20. Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation. 2010; 89:911-999.
  21. Chen IY, Chang SC, Wu HY, Yu TC, Wei WC, Lin S, Chien CL, Chang MF*. Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway. J Virol. 2010; 84:7703-12.
  22. Chen HF, Kuo HC, Lin SP, Chien CL, Chiang MS, Ho HN*. Hypoxic Culture Maintains Self-Renewal and Enhances Embryoid Body Formation of Human Embryonic Stem Cells. Tissue Eng. Part A. 2010; 16:2901-2913.
  23. Yeh LK, Liu CY, Kao WW, Huang CJ, Hu FR, Chien CL*, Wang IJ*. Knockdown of zebrafish lumican gene (ZLUM) causes scleral thinning and increased size of scleral coats. J Biol Chem. 2010; 285:28141-28155.
  24. Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC*.. KLF4 Contributes to Maintenance of Telomerase Activity in Stem Cells. Stem Cells. 2010;28:1510-1517.
  25. Huang WC, Chen YJ, Chien CL, Kashima H, Lin KC*. Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects. Am J Transl Res. 2010; 3:48-60.

Publications (2011- 2020)
  1. Chen SY, Chiu LY, Maa MC, Wang JS, Chien CL, Lin WW. zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy. 2011; 7(2):217-28
  2. Tseng KW, Peng ML, Wen YC, Liu KJ and Chien CL*. Neuronal degeneration in autonomic nervous system of dystonia musculorum mice. J Biomed Sci. 2011; 18:9.
  3. Huang HP, Chen PH, Hwu WL, Chuang CY, Chien YH, Stone L, Chien CL, Li LT, Chiang SC, Chen HF, Ho HN, Chen CH, Kuo HC*. Human Pompe disease induced pluripotent stem cells for pathogenesis modeling, drug testing and disease marker identification. Hum Mol Genet. 2011; 20(24):4851-64.
  4. Lee WC, Chen YY, Kan D, Chien CL*. A neuronal death model: Overexpression of neuronal intermediate filament protein peripherin in PC12 cells. J Biomed Sci. 2012; 19:8. doi:10.1186/1423-0127-19-8.
  5. Lee WC, Kan D, Chen YY, Han SK, Lu KS, Chien CL*. Suppression of extensive neurofilament phosphorylation rescues α-internexin/peripherin-overexpressing PC12 cells from neuronal cell death. PLoS One. 2012; 7(8):e43883. doi:10.1371.
  6. Chen YT, Tsai MS, Yang TL, Ku AT, Huang KH, Huang CY, Chou FJ, Fan HH, Hong JB, Yen ST, Wang WL, Lin CC, Hsu YC, Su KY, Su IC, Jang CW, Behringer RR, Favaro R, Nicolis SK, Chien CL, Lin SW*, Yu IS*. R26R-GR: A cre-activable dual fluorescent protein reporter mouse. PLoS One. 2012; 7(9):e46171.
  7. Chen YL, Chang MC, Chen CA, Lin HW, Cheng WF*, Chien CL*. Depletion of regulatory T lymphocytes reverses the imbalance between pro- and anti-tumor immunities via enhancing antigen-specific T cell immune responses. PLoS One. 2012; 7:e47190.
  8. Chen SJ, Tsai JC, Lin CY, Chang CK, Tseng TH, Chien CL*. Brain-derived neurotrophic factor-transfected and nontransfected 3T3 fibroblasts enhance migratory neuroblasts and functional restoration in mice with intracerebral hemorrhage . J Neuropathol Exp Neurol. 2012; 71:1123-1136.
  9. Peng ML, Tsai CY, Chien CL, Hsiao JCJ, Huang SY, Lee CJ, Lin HY, Wen YC and Tseng, KW*. The influence of low-powered family LED lighting on eyes in mice experimental model. Life Science Journal. 2012; 9:477-482.
  10. Liu CH, and Chien CL*. Molecular cloning and characterization of chicken neuronal intermediate filament protein α-internexin. J Comp Neurol. 2013; 521:2147-64.
  11. Liu CH, Wang IJ, Wei FD, Chien CL*.Neuronal intermediate filament α  - internexin is expressed by neuronal lineages in the developing chicken retina. Exp Eye Res. 2013; 110:18-25.
  12. Wang NK, Lai CC, Liu CH, Yeh LK, Chou CL, Kong J, Nagasaki T, Tsang S, and Chien CL*. Origin of fundus hyperautofluorescent (AF) spots, and their role in retinal degeneration in a mouse model of Goldmann-Favre Syndrome. Dis Model Mech. 2013; 6:1113-22. doi: 10.1242/dmm.012112.
  13. Hou PS, Chuang CY, Kao CF, Chou SJ, Stone L, Ho HN, Chien CL* and Kuo HC*. LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1. Nucleic Acids Res. 2013; 41:7753-7770.
  14. Shen WC, Liang CJ, Wu VC, Wang SH, Young GH, Lai IR, Chien CL, Wang SM, Wu KD, Chen YL. Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Stem Cells Dev. 2013; 22:1408-1418.
  15. Chen YL, Cheng WF, Chang MC, Lin HW, Huang CT, Chien CL* and Chen CA*. Interferon-gamma in ascites could be a predictive biomarker of outcome in ovarian carcinoma. Gynecol Oncol. 2013; 131:63-68.
  16. Peng ML, Lee CJ, Chien CL, Liu CL, Tsai CY, Wen YC, Tseng KW*. Protective effects of (-)-epigallocatechin gallate on blue light-induced damage in retinoblastoma Y79 cells by activating estrogen receptor pathway. Life Science Journal, 2013; 10: 192-198.
  17. Chen HF, Jan PS, Kuo HC, Wu FC, Lan CW, Huang MC, Chien CL, Ho HN*. Granulosa cells and retinoic acid co-treatment enrich potential germ cells from manually selected Oct4-EGP expressing human embryonic stem cells.  Reprod Biomed Online. 2014; 05:009. doi: 10.1016/j.rbmo.
  18. Hong JH, Lee WC, Hsu YM, Liang HJ, Wan CH, Chien CL*, Lin CY*. Characterization of the biochemical effects of naphthalene on the mouse respiratory system using NMR-based metabolomics. J Appl Toxicol. 2014; 34(12):1379-1388
  19. Hou PS, Huang WC, Chiang W, Lin WC, Chien CL*. Impaired neural differentiation potency by retinoic acid receptor-α pathway defect in induced puripotent stem cells. Cell Reprogram. 2014;16:467-476. doi: 10.1089/cell.2014.0029.
  20. Hong JB, Chou FJ, Ku Amy T., Fan HH, Lee TL, Huang YH, Yang TL , Su IC, Yu IS, Lin SW, Chien CL, Ho HN, Chen YT*. A nucleolus-predominant piggybac transposase, NP-mPB, Mediates elevated transposition efficiency in mammalian cells. PLoS One. 2014; 9(2):e89396
  21. Chao CC, Kan D, Lu KS, Chien CL*. The role of microRNA-30c in the self-renewal and differentiation of C6 glioma cells. Stem Cell Res. 2015; 14(2):211-23. doi: 10.1016/j.scr.2015.01.008.
  22. Li YC, Chen SJ and Chien CL*. Erythropoietin produced by genetic-modified NIH/3T3 fibroblasts enhances the survival of degenerating neurons. Brain Behav. 2015; 5(8) (Cover), doi:10.1002/brb3.356.
  23. Chao CC, Kan D, Lo TH, Lu KS, Chien CL*.  Induction of neural differentiation in rat c6 glioma cells with taxol. Brain Behav. 2015; 5(12) (Cover), doi: 10.1002/brb3.414
  24. Liao ML, Peng WH, Kan D, Chien CL*. Developmental Pattern of the neuronal intermediated filament inaa in the zebrafish retina . J Comp Neurol. 2016; 524(18):3810-3826. doi:10.1002/cne.24033.
  25. Lee WD, Wang KC, Tsai YF, Chou PC, Tsai LK, Chien CL*. Subarachnoid Hemorrhage Promotes Proliferation, Differentiation, and Migration of Neural Stem Cells via BDNF Upregulation. PLoS One. 2016 Nov 10;11(11) : e0165460. doi: 10.1371/journal.pone.0165460.
  26. Numpaisal PO, Rothrauff BB, Gottardi R, Chien CL, Tuan RS*. Rapidly dissociated autologous meniscus tissue enhances meniscus healing: An in vitro study. Connect Tissue Res. 2017;58(3-4):355-365. doi: 10.1080/03008207.
  27. Pu CM, Liu CW, Liang CJ, Yen YH, Chen SH, Jiang-Shieh YF, Chien CL, Chen YC, Chen YL*. Adipose-Derived Stem Cells Protect Skin Flaps against Ischemia/Reperfusion Injury via IL-6 Expression. J Invest Dermatol. 2017 Jun;137(6):1353-1362. 
  28. Hsieh MH, Chen YT, Chen YT, Lee YH, Lu J, Chien CL, Chen HF, Ho HN, Yu CJ, Wang ZQ, Teng SC*. PARP1 controls KLF4-mediated telomerase expression in stem cells and cancer cells. Nucleic Acids Res. 2017 Oct 13;45(18):10492-10503.
  29. Wong CW, Chen YT, Chien CL, Yu TY, Rwei SP, Hsu SH*. A simple and efficient feeder-free culture system to up-scale iPSCs on polymeric material surface for use in 3D bioprinting. Mater Sci Eng C Mater Biol Appl. 2018 Jan 1;82:69-79.
  30. Hsin WC, Chen CH, Chang CY, Peng WH, Chien CL, Chang MF, Chang SC*. Nucleocapsid protein-dependent assembly of the RNA packaging signal of Middle East respiratory syndrome coronavirus. J Biomed Sci. 2018; 25(1):47.
  31. Liao ML, Peng WH, Kan D, Chien CL*. Distribution patterns of the zebrafish neuronal intermediate filaments inaa and inab. J Neuro Res. 2018; 00:1-13. doi: 10.1002/jnr.24347.
  32. Chou PC, Tsai YC, Chen SJ, Tsai LK*Chien CL*. Intracerebral transplantation of erythropoietin‐producing fibroblasts facilitates neurogenesis and functional recovery in an ischemic stroke model. Brain Behav. 2019 ;e01274.doi: 10.1002/brb3.1274.      
  33. Wu A*, Kielstein H, Sakurai T, Noel G, Viranta-Kovanen S, Chien CL, Bernd P. Internationalization of medical education-building a program to prepare future leaders in healthcare. Med Sci Educ. 2019;29(2):535–47. (International Collaboration).      
  34. Sun N.-Y.; Chen Y.-L.; Lin H.-W.; Chiang Y.-C.; Chang C.-F.; Tai Y.-J.; Chen C.-A.; Sun W.-Z.; Chien CL; Cheng W.-F. Immune checkpoint Ab enhances the antigen-specific anti-tumor effects by modulating both dendritic cells and regulatory T lymphocytes. Cancer Letters. 2019 vol 444 p20-34.
  35. Chen Y.-L.; Lin H.-W.; Chien CL.; Lai Y.-L.; Sun W.-Z.; Chen C.-A.; Cheng W.-F. BTLA blockade enhances Cancer therapy by inhibiting IL-6/IL-10-induced CD19high B lymphocytes. Journal for ImmunoTherapy of Cancer. 2019 vol 7:1 p313.
  36. Shih J.-C.; Lin H.-H.; Hsiao A.-C.; Su Y.-T.; Tsai S.; Chien CL.; Kung H.-N. Unveiling the role of microRNA-7 in linking TGF-β-Smad-mediated epithelial-mesenchymal transition with negative regulation of trophoblast invasion. FASEB Journal. 2019 vol 33:5 p 6281-6295.
  37. Pu C.-M.; Chen Y.-C.; Chen Y.-C.; Lee T.-L.; Peng Y.-S.; Chen S.-H.; Yen Y.-H.; Chien CL; Hsieh J.-H.; Chen Y.-L. Interleukin-6 from Adipose-Derived Stem Cells Promotes Tissue Repair by the Increase of Cell Proliferation and Hair Follicles in Ischemia/Reperfusion-Treated Skin Flaps. Mediators of Inflammation. 2019 vol 2019 p 2343867.
  38. Wu A, Noel G, Wingate R, Kielstein H, Sakurai T, Viranta-KovanenS, Chien CL, Traxler H, Waschke J, Vielmuth F, Gill M, Kitahara S, Kato Y, Keay K, Olson J, Bernd P. An International Partnership of 12 Anatomy Departments – Improving Global Health through Internationalization of Medical Education. Annals of Global Health. 2020; 86(1): 27, 1–14.

Publications 2021-

96. Wu A*, Yu ACX, Chang CS, Goel R, Sagoo MG, Sakurai T, Viranta-Kovanen S, Chien CL, Traxler H, Waschke J, Kitahara S, Keay K, Olsen J, Brassett C, Batti SE, Vielmuth F, Sigmund AM, Zeroual M, Kunzel C, Bernd P, Wingate R, Kielstein H, Noel GPJC Initiating Students' Reflections on Life's Passing in the Anatomy Course - an International Observation at 14 Universities. Ann Anat. 2021, 237: 151741.

97. Wu A*, Maddula V, Yu ACX, Goel R, Shimizu H, Chien CL, Wingate R, Sagoo MG, Kielstein H, Traxler H, Brassett C, Waschke J, Vielmuth F, Keay K, Zeroual M, Sakurai T, Olsen J, El-Batti S, Viranta-Kovanen S, Kitahara S, Kunzel C, Bernd P, Noel GPJC. An Observation of Healthcare Professions Students' Perceptions During the COVID-19 Pandemic. Med Sci Educ. 2021, 18:1-9.

98. Wu A*, Maddula V, Singh J, ; Sagoo MG, Chien CL, Wingate R, Kielstein H, Traxler H, Brassett C, Waschke J, Vielmuth F, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Kitahara S, Keay K, Kunzel C, Bernd P, Noël GPJC. Alternatives to Student Outbound Mobility - Improving Students’ Cultural Competency Skills Online to Improve Global Health without Travel. Med Sci Educ. 2021. doi: 10.1007/s40670-021-01332-9. 

99. Luo WC, Liao ML, Chien CL*. Neural differentiation of glioblastoma cell lines via a herpes simplex virus thymidine kinase/ganciclovir system driven by a glial fibrillary acidic protein promoter. PLoS One. 2021.doi: 10.1371/journal.pone. 0253008

100. Peng WH, Liao ML, Huang WC, Liu PK, Levi SR, Tseng YJ, Lee CY, Yeh LK, Chen KJ, Chien CL* and Wang NK*. Conditional Deletion of Activating Rearranged During Transfection Receptor Tyrosine Kinase Leads to Impairment of Photoreceptor Ribbon Synapses and Disrupted Visual Function in Mice. Front. Neurosci. 2021, 15:728905. doi: 10.3389/fnins.2021.728905.

101. Numpaisal PO, Jiang CC, Hsieh CH, Chiang H, Chien CL*. Prospective Application of Partially Digested Autologous Chondrocyte for Meniscus Tissue Engineering. Pharmaceutics 2022 Mar 10;14(3):605. doi: 10.3390/pharmaceutics14030605.

102. Liao ML, Yeh CC, Lue JH, Chien CL, Hsu SH, Chang MF. Benefits of a bilingual web-based anatomy atlas for nursing students in learning anatomy. BMC Med Educ. 2022 May 4;22(1):341. doi: 10.1186/s12909-022-03405-8.

103. Wu A, Xiao QY, McWatt S, Utomo R, Talis A, Saraci K, Brassett C, Sagoo MG, Wingate R, Chien CL, Traxler H, Waschke J, Vielmuth F, Yamada Y, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Keay K, Stewart W, Kunzel C, Bernd P, Kielstein H, Noël GPJC. The Anatomy Course During COVID‑19: The Impact of Cadaver‑Based Learning on the Initiation of Reflection on Death. Med Sci Educ. 2022 Sep 8:1-12. doi: 10.1007/s40670-022-01609-7. 

104. Wu A, McWatt SC, Utomo R, Talis A, Xiao QY, Saraci K, Brassett C, Sagoo MG, Wingate R, Chien CL, Traxler H, Waschke J, Vielmuth F, Sigmund A, Yamada Y, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Keay K, Stewart W, Mao Y, Lang A, Kunzel C, Bernd P, Kielstein H, Noël GPJC. A thematic analysis of students' discussions on death and body donation in international online focus groups. Anat Sci Educ. 2023 Mar 7. doi: 10.1002/ase.2265. 

 105. Utomo R, McWatt SC, Talis A, Xiao QY, Saraci K, Waschke J, Sigmund AM, Gill Sagoo M, Wingate R, Brassett C, Chien CL, Traxler H, Sakurai T, Zeroual M, Olsen J, El-Batti S, Viranta-Kovanen S, Yamada Y, Keay KA, Kitahara S, Stewart W, Mao Y, Lang A, Kunzel C, Bernd P, Patel S, Buehler L, Kielstein H, Preker A, Hardy MA, Noël GPJC, Wu A*. Health profession students' outlooks on the medical profession during the COVID-19 pandemic: a global perspective. J Commun Healthc. 2023 May 22:1-15. doi: 10.1080/17538068.2023.2214391. Online ahead of print.PMID: 37213185

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