Tien-Yau Luh
Professor of Polymer Science and Engineering
Professor of Chemistry

■Educational Background

B.S.          National Taiwan University         1967
Ph.D.        University of Chicago                 1974

■Selected Publications

1. Chen, R.-M.; Luh, T.-Y. "A General Synthesis of Vinylic Silyl Hydrides Using Nickel Catalysis. Applications to the Syntheses of Silylene-Tethered Conjugated Polymers," Tetrahedron, 54, 1197-1206 (1998).
2. Hsieh, Y.-T.; Lee, G.-H.; Wang, Y.; Luh, T.-Y. "1,4-Di-O-tert-alkyl-L-threitols as the Chiral Auxiliary in the Asymmetric Nucleophilic Addition of Alkyllithiums to Hydrazones," J. Org. Chem., 63, 1484-1490 (1998).
3. Hsu, S.-C.; Wu, C.-C.; Luh, T.-Y.; Chou, C.-K.; Han, S.-H.; Lai, M.-Z. "Apoptotic Signal of Fas Is Not Mediated by Ceramide," Blood, 91, 2658-2663 (1998).
4. Huang, Y.-L.; Shen, C. K.-F.; Luh, T.-Y.; Yang, H. C.; Hwang K. C.; Chou, C.-K. "Blockage of Apoptotic Signaling of Transforming Growth Factor- in Human Hepatoma Cells by Carboxyfullerene," Eur. J. Biochem., 254, 38-43 (1998).
5. Luh, T.-Y.; Liu, S.-T. "Synthetic Applications of Allylsilanes and Vinylsilanes," In The Chemistry of Organosilicon Compounds; Vol. 2, Rappoport, Z.; Apeloig, Y. Eds.; Wiley: Chicester, 1793-1868 (1998).
6. Kanakamma, P. P.; Huang, S.-L.; Juo, C.-G.; Her, G.-R.; Luh, T.-Y. "Aziridino-Aza Fulleroid. Interconversion between Aziridino-Aza Fulleroid and Bisazafulleroid," Chem. Eur. J., 4, 2037-2042 (1998).
7. Shiau, C.-W.; Sattigeri, J. A.; Shen, C. K.-F.; Luh, T.-Y. "Organosulfur Compounds as Promoters in the Mo(CO)6-Catalyzed Ring Opening Metathesis Polymerization of Norbornenes," J. Organomet. Chem., 572, 291-293 (1999).
8. Cheng, W.-L.; Shaw, Y.-J.; Yeh, S.-M.; Kanakamma, P. P.; Chen, Y.-H.; Chen, C.; Shieu, J.-C.; Yiin, S.-J.; Lee, G.-H.; Wang, Y.; Luh, T.-Y. "Chelation-Assisted Regioselective Cleavage of Acetals with Grignard Reagents. Selective Synthesis of Partially Protected Monosaccharide and Related Compounds", J. Org. Chem., 64, 532-539 (1999).
9. Gao, Z.; Lee, C. S.; Bello, I.; Lee, S. T.; Chen, R.-M.; Luh, T.-Y.; Shi, J.; Tang, C. W. "Bright-Blue Electroluminescence from a Silyl-Substituted ter-(Phenylene-vinylene) Derivative," Appl. Phys. Lett., 74, 865-867 (1999).
10. Sattigeri, J. A.; Shiau, C.-W.; Hsu, C. C.; Yeh, F. F.; Liou, S.; Jin, B.-Y.; Luh, T.-Y. "Remarkable Enhancement of Second-Order Nonlinear Optical Properties of Polynorbornenes Having Pendant Chromophores. Use of Hyper-Rayleigh Scattering to Estimate the Tacticity of Rigid Rod Polymers," J. Am. Chem. Soc., 121, 1607-1608 (1999).
11. Chen, R.-M.; Deng, Z.; Lee, S. T.; Luh, T.-Y. "Silylene-Tethered Divinylarene Copolymers. A New Class of Electroluminescent Polymer," In Semiconductive Polymers, ACS Symposium Series; Hsieh, B. R.; Galvin, M.; Wei, Y. Eds.; ACS: Washington D. C., Chapter 23, pp 374-383 (1999).
12. Lin, A. M. Y.; Chyi, B. Y.; Wang, S. D.; Yu, H.-h.; Kanakamma, P. P.; Luh, T.-Y.; Chou, C. K.; Ho, L. T. "Carboxyfullerene Prevents Iron-Induced Oxidative Stress in Rat Brain," J. Neurochem., 72, 1634-1640 (1999).
13. Tsao, N.; Kanakamma, P. P.; Luh, T.-Y.; Chou, C.-K.; Lei, H.-Y. "Inhibition of Eshcerichia coli-Induced Meningitis by Carboxylfullerene," Antimicrob. Agents. Chemother., 43, 2273-2277 (1999).
14. Hsu, C.-C.; Huang, T.-H.; Liu, S.; Yeh, F.-F.; Jin, B.-Y.; Sattigera, J. A.; Shiau, C.-W.; Luh, T.-Y. "Conformation of Substituted Polynorbornenes Studied by Hyper-Rayleigh Scattering at 1064 nm," Chem. Phys. Lett.,311, 355-361 (1999).
15. Wang, I. C.; Tai, L. A.; Lin, D. D.; Kanakamma, P. P.; Shen, C. K.-F.; Luh, T.-Y.; Cheng, C. H.; Hwang, K. C. "C60 and Water-Soluble Fullerene Derivatives as Antioxidants Against Radical-Initiated Lipid peroxidation," J. Med. Chem., 4614-4620 (1999).
16. Tseng, H.-R.; Lee, C.-F.; Yang, L.-M.; Luh, T.-Y. "Umpolung of Carbon-Sulfur bonds. Synthesis of Substituted Allenes from Propargylic Dithioacetals," J. Org. Chem., 64, 8582-8587 (1999).
17. Lin, A.M.-Y.; Luh, T.-Y.; Chou, C.-K.; Ho, L.-T. "The Antioxidative Effect of Carboxyfullerenes (C3/D3) on Iron-Induced Oxidative Injury in CNS," Ann. N. Y. Acad. Sci., 890, 340-351 (1999).
18. Lee, C.-F.; Yang, L.-M.; Hwu, T.-Y.; Feng, A.-H.; Tseng, J.-C.; Luh, T.-Y. "One-Pot Synthesis of Substituted Furans and Pyrroles from Propargylic Dithioacetals. New Annulation Route to Highly Photoluminescent Oligoaryls," J. Am. Chem. Soc., 122, 4992-4993 (2000).
19. Hsieh, Y.-T.; Luh, T.-Y. "Geminal Disilylmethylation of Dioxolanes with Silylmethyl Grignard Reagents," Heterocycles, 52, 1125-1131 (2000).
20. Lin, T.-S.; Dugan, L. L.; Luh, T.-Y. "EPR Studies of Free Radical Reactions of Carboxyfullerenes," Appl. Magn. Reson., 18, 321-331 (2000).
21. Luh, T.-Y.; Basu, S.; Chen, R.-M. "Electroluminescent Polymeric Materials," Curr. Sci., 78, 1352-1357 (2000).
22. Luh, T.-Y.; Leung, M.-K.; Wong, K.-T. "Transition Metal-Catalyzed Activation of Aliphatic C-X Bonds in Carbon-Carbon Bond Formation," Chem. Rev., 100, 3187-3204 (2000).
23. Chiang, C.-C.; Chen, Y.-H.; Hsieh, Y.-T.; Luh, T.-Y. "Selective Deprotection of Acetals with Me3SiCH2MgCl. Peterson-Type Olefination of Acetals," J. Org. Chem., 65, 4694-4697 (2000).
24. Lin, Y.-L.; Lei, H.-Y.; Wen, Y.-Y.; Luh, T.-Y.; Chou, C.-K.; Liu, H.-S. "Light Independent Inactivation of Dungue-2 Virus by Carboxyfullerene C3 Isomer," Virology, 275, 258-262 (2000).
25. Chen, M.-C.; Hsu, T.-L.; Luh, T.-Y.; Hsieh, S.-L. "Overexpression of Bcl-2 Enhances LIGHT and IFN- -mediated Apoptosis in Hep3BT2 Cells," J. Biol. Chem., 275, 38794-38801 (2000).
26. Churikov, V. M.; Hung, M. F.; Hsu, C. C.; Shiau, C.-W.; Luh, T.-Y. "Encoding of Macroscopic Second-Order Non-linearity via All-Optical Polar Alignment in Substituted Norbornene Polymer Thin Films," Chem. Phys. Lett., 322, 19-25 (2000).
27. Luh, T.-Y.; Chen, R.-M.; Hwu, T.-Y.; Basu, S.; Shiau, C.-W.; Lin, W.-Y.; Jin, B.-Y.; Hsu, C. C. "Rational Designing of Polymers for Optoelectronic Interests," Pure Appl. Chem., 73, 243-246 (2001).
28. Lin, H.-S.; Lin, T.-S.; Lai, R.-S.; D'Rosario, T.; Luh, T.-Y. "Fullerenes as a New Class of Radioprotectors," Int. J. Radiat. Biol., 77, 235-239 (2001).
29. Shiau, C.-W.; Shen, C. K.-F.; Pan, W.; Kuo, C.-H.; Luh, T.-Y. "W(CO)6-Mediated Desulfuroligomerization of Bis-Dithioacetals. New Synthesis of Substituted Oligo(phenylene-vinylenes)," J. Organomet. Chem., 624, 63-68 (2001).
30. Tsao, N.; Luh, T.-Y.; Chou, C.-K.; Wu, J.-J.; Lin, Y.-S.; Lei, H.-Y. "Inhibition of Group Steptococcus Infection by Carboxyfullerene," Antimicrob. Agents. Chemother., 45, 1788-1793 (2001).
31. Chiang, C.-C.; Luh, T.-Y. "Allylic Dithioacetal as a Propene-1,3-Zwitterion Synthon. Regioselective Conversion of C-S Bonds in Allylic Dithioacetals into C-C Bonds," Synlett, 977-979 (2001).
32. Wu, C. C.; Chen, C. W.; Lin Y. T.; Yu, H.-L.; Hsu, J.-H.; Luh, T.-Y. "Programmable Organic Light Emitting Devices," Appl. Phys. Lett., 79, 3023-3025 (2001).
33. Feng, A.-H.; Chen, J.-Y.; Yang, L.-M.; Lee, G.-H.; Wang, Y.; Luh, T.-Y. "Unexpected Lewis Acid-Mediated Dimerization of 1,3-Diarylpropargylic Alcohols," J. Org. Chem., 66, 7922-7924 (2001).
34. Tsao, N.; Wu, C. M.; Hsu, H. P.; Liu, C. C.; Luh, T.-Y.; Chou, C.-K.; Lei, H.-Y. "Inhibition of the increased permeability of blood-brain barrier in Escherichia coli-induced meningitis by carboxyfullerene," Fullerene Sci. Tech., 9, 307-320 (2001).
35. Murthy, V. R. K.; Luh, T.-Y. "Synthesis of Silylene-Spaced Divinylnaphthalene Copolymers," Arkivoc, 2 (10), TG-185G. (2001).
36. Shieu, J.-C.; Shaw, Y.-J.; Luh, T.-Y. "Synthesis and Reactions of Highly Protected Mannosamines," J. Chin. Chem. Soc., 48, 1035-1040 (2001).
37. Sudhakar, S.; Lee, G.-H.; Wang, Y.; Hsu, J.-H.; Luh, T.-Y. "First Siloxane Tethered Paracyclophane," J. Organomet. Chem., 646, 167-170 (2002).
38. Tsao, N.: Luh, T.-Y.; Chou, C.-K.; Chang, T.-Y. ; Wu, J.-J. ; Liu, C.-C. ; Lei, H.-Y. "In vitro Action of Carboxyfullerene" J. Antimicrob. Chemother., 49, 641-649 (2002).
39. Luh, T.-Y. "Recent Advances on the Synthetic Applications of the Dithioacetal Functionality," J. Organomet. Chem., 653, 209-214 (2002).
40. Chen, C.-W.; Cho, T.-Y.; Wu, C.-C.; Yu, H.-L.; Luh, T.-Y. "Fuzzy-Junction Organic Light-Emitting Devices," Appl. Phys. Lett, , 81, 1570-1572 (2002).
41. Luh, T.-Y.; Tseng, J.-C. "Umpolung of the Carbon-Sulfur Bonds," In Latest Frontiers of Organic Synthesis, Kobayashi, Y., Ed.; Research Signpost: Kerala, India, pp 133-146 (2002).
42. Lin, A. M. Y.; Fang, S. F.; Lin, S. Z.; Chou, C. K.; Luh, T.-Y.; Ho L. T. "Local carboxyfullerene protects cortical infarction in rat brain," Neurosci. Res., 43, 317-321 (2002).
43. Sudhakar, S.; Luh, T.-Y. "Norbornadiene as an efficient hydrogen scavenger for the palladium catalyzed conversion of hydrosilanes to alkoxysilanes," J. Org. Chem., 67, 6860-6862 (2002).
44. Cheng, Y.-J.; Hwu, T.-Y.; Hsu, J.-H.; Luh, T.-Y. "Intrachain Energy Transfer in Silylene-Spaced Alternating Donor-Acceptor Divinylarenes Copolymers," Chem. Commun., 1978-1979 (2002).
45. Zhang, L.-Z.; Chen, C.-W.; Lee, C.-F.; Wu, C.-C.; Luh, T.-Y. "Non-amine-based Furan-containing Oligoaryls as Efficient Hole Transporting Materials," Chem. Commun., 2336-2337 (2002).
46. Lee, C.-F.; Liu, C.-Y.; Song, H.-C.; Luo, S.-J.; Tseng, J.-C.; Tso, H.-H.; Luh, T.-Y. "Bidirectional Iterative Synthesis of Alternating Benzene-Furan and Oligomers toward Molecular Wires," Chem. Commun., 2824-2825 (2002).
47. Liu, C-Y.; Luh, T.-Y. "Combining Furan Annulation, Heck Reaction, and Sonogashira Coupling for the Synthesis of Oligoaryls," Org. Lett., 4, 4305-4307 (2002).