Research

Circulating tumor cells via Microfluidics

Metastasis to vital organs is among the most life threatening cause to cancer patients. Hence, it is crucial to prevent metastasis. Applying microfluidic platform and different separation/detection strategies, we are working on a more economical screening/diagnosis with early alert than conventional choices.

Cellular analysis chip

Since 2003, this group was devoted to a new microfluidic device. A non-invasive hydrodynamic trapping method for bio-particles in a microfluidic device was presented. Lorentz-force-based resonating device was utilized to generate counter-rotating microvortices (CRMV) and to trap the bioparticles. The specific flow patterns earlier discovered demonstrates a flexible platform for cells trapping.

Cellular microarray

Cellular microarray provides a platform to visualize and index cells amenable to high-throughput studies. We present a dielectrophoresis (DEP)-based cellular microarray chip integrated with a concentration gradient generator for cellular microarray applications. Positive DEP force was applied to pattern cells on collagen-coated planar interdigitated ring electrode (PIRE) array.

Cellular microarray

We exploit laser drilling technique to create an hourglass-shaped aperture for cellular electrophysiology. CO2 laser was applied to drill on borosilicate cover glass. Special reflow phenomenon occurred at the rear of the glass surface resulted in the unique tailored-contour aperture. Smooth, debris-free, and freshly activated nature of the aperture revealed the capability of planar patch-clamp application.

Cellular microarray

The goal of research is to develop a microfluidics device to estimate sperm quality. Nowadays, people face more and more serious problem of infertility mainly due to poorer semen quality. In order to analyze quality of semen precisely and conveniently, a reliable, easy-operation, and low cost microfluidics device provides the promise to fit the need.