JMFLab

205.	Shie, J.-J.; Chen, C.-A.; Lin, C.-C.; Ku, A. F.; Cheng, T.-J. R.; Fang, J.-M.; Wong, C.-H. Org. Biol. Chem. 2010, 8, 4451–4462. Regioselective Synthesis of Di-C-glycosylflavones Possessing Anti-inflammation Activities.
204.	Wen, W.-H.; Wang, S.-Y.; Tsai, K.-C.; E. Cheng, Y.-S.;, Yang, A.-S.; Fang, J.-M.; Wong, C.-H. Bioorg. Med. Chem. 2010, 18, 4074–4084. Analogues of Zanamivir with Modified C4-Substituents as the Inhibitors against the Group-1 Neuraminidases of Influenza Viruses.
203.	Liu, C.-Y.; Wang, J.-T.; Shih, H.-W.; Hsu, Y.-F.; Chang, Y.-F.; Chen, C.-W.; Chen, S.-K.; Wang, Y.-C.; Cheng, T.-J. R.; Ma, C.; Wong, C.-H.; Fang, J.-M.; Cheng, W.-C. Org. Lett. 2010, 12, 1608–1611. Synthesis and Evaluation of a New Fluorescent Transglycosylase Substrate: Lipid II-based Molecule Possessing a Dansyl-C20 Polyprenyl Moiety.
202.	Chang, C.-C.; Ku, A. F.; Tseng, Y.-Y.; Yang, W.-B.; Fang, J.-M.; Wong, C.-H. J. Nat. Prod. 2010, 73, 229–232. *6,8-Di-C-glycosyl Flavonoids from Dendrobium* huoshanense.**
201.	Lin, C.; Hung, W.-T.; Chen, C.-H.; Fang, J.-M.; Yang, W.-B. Rapid Commun. Mass Spect. 2010, 24, 85–94. A New Naphthimidazole Derivative for Saccharide Labeling with Enhanced Sensitivity in Mass Spectrometry Detection.
200.	Wen, W . -H .; Lin, M.; Su, C.-Y.; Wang, S.-Y.; Cheng, Y.-S. E.; Fang, J.-M.; Wong, C.-H. J. Med. Chem. 2009 , 52 , 4903–4910. Synergistic Effect of Zanamivir–Porphyrin Conjugates on Inhibition of Neuraminidase and Inactivation of Influenza Virus.
199.	Chen, C.-S.; Yu, Y.-P.; Lin, B.-C.; Gervay-Hague, J.; Fang, J.-M.; Hsu, C.-P.; Wu, S.-H. Eur. J. Org. Chem. 2009 , 3351–3356. The Observation of C - H···O sp3 Hydrogen Bond in tri-Sialic Acid Lactone and Its Implication in Cooperative Lactonization.
198.	Cho, C.-C.; Liu, J.-N.; Chien, C.-H.; Shie, J.-J.; Chen, Y.-C.; Fang, J.-M. J. Org. Chem. 2009 , 74 , 1549–1556. Direct Amidation of Aldoses and Decarboxylative Amidation of α-Keto Acids: An Efficient Conjugation Method for Unprotected Carbohydrate Molecules.
197.	Chen, K.-H.; Liao, J.-H.; Chan, H.-Y.; Fang, J.-M. J. Org. Chem. 2009 , 74 , 895–898. A Fluorescence Sensor for Detection of Geranyl Pyrophosphate by Chemo-Ensemble Method.
196.	Chen, K.-H.; Yang, J.-S.; Hwang, C.-Y.; Fang, J.-M. Org. Lett. 2008 , 10 , 4401–4404. Phospholipid-Induced Aggregation and Anthracene Excimer Formation.
195.	Chang, Y.-F.; Liu, C.-Y.; Guo, C.-W.; Wang, Y.-C.; Fang, J.-M.; Cheng, W.-C. J. Org. Chem. 2008 , 73 , 7197–7203. Solid-Phase Organic Synthesis of Polyisoprenoid Alcohols Using Traceless Sulfone Linker.
194.	Kuo, C.-J.; Shie, J.-J.; Fang, J.-M.; Yen, G.-R.; Hsu, J. T.-A.; Liu, H.-G.; Tseng, S.-N.; Chang, S.-C.; Lee, C.-Y.; Shih, S.-R.; Liang, P.-H. Bioorg. Med. Chem. 2008 , 16 , 7388–7398. Design, Synthesis, and Evaluation of 3C Protease Inhibitors as Anti-Enterovirus 71 Agents.
193.	Shie, J.-J.; Fang, J.-M.; Wong, C.-H. Angew. Chem. 2008 , 120 , 5872–5875. Angew. Chem. Int. Ed. 2008 , 47 , 5788–5791. A Concise and Flexible Synthesis of the Potent Anti-Influenza Agents Tamiflu and Tamiphosphor.
192.	Hsieh, Y. S.-Y. ; Chien, C.; Liao, S. K. - S.; Liao, S.-F.; Hung, W.-T.; Yang, W.-B.; Lin, C.-C.; Cheng, T.-J. R.; Chang, C.-C.; Fang, J.-M.; Wong, C.-H. Bioorg. Med. Chem. 2008 , 16 , 6054–6068. *Structure and Bioactivity of the Polysaccharides in Medicinal Plant Dendrobium huoshanense* .**
191.	Lin, C.; Lai, P.-T.; Liao, S. K.-S.; Hung, W.-T.; Yang, W.-B.; Fang, J.-M. J. Org. Chem. 2008 , 73 , 3848–3853. Using Molecular Iodine in Direct Oxidative Condensation of Aldoses with Diamines: An Improved Synthesis of Aldo-benzimidazoles and Aldo-naphthimidazoles for Carbohydrate Analysis.
190.	Su, C.-Y.; Wang, S.-Y.; Shie, J.-J.; Jeng, K.-S.; Temperton, N. J.; Fang, J.-M.; Wong, C.-H.; Cheng, Y.-S. E. Antiviral Res . 2008 , 79 , 199–205 . In Vitro Evaluation of Neuraminidase Inhibitors Using the Neuraminidase Dependent Release Assay of Hemagglutinin-Pseudotyped Viruses.
189.	Lee , J . -C .; Shih , S . -R .; Chang , T . -Y .; Tseng , H . -Y .; Shih , Y . -F .; Yen , K . -J .; Chen , W . -C .; Shie , J . -J .; Fang , J . -M .; Liang , P . -H .; Chao , Y . -S .; Hsu , J . T.-A. Anal. Biochem. 2008 , 375 , 115–123. A Mammalian Cell-based Reverse Two-Hybrid System for Functional Analysis of 3C Viral Protease of Human Enterovirus 71.
188.	Lee, C.-C.; Kuo, C.-J.; Hsu, M.-F.; Liang, P.-H.; Fang, J.-M.; Shie, J.-J.; Wang, H.-J. FEBS Lett. 2007 , 581 , 5454–5458. Structural Basis of Mercury- and Zinc-Conjugated Complexes as SARS-CoV 3C -like Protease Inhibitors.
187.	Shie, J.-J.; Fang , J.-M.; Wang, S.-Y.; Tsai, K.-C.; Cheng, Y.-S. E.; Yang, A.-S.; Hsiao, S.-C.; Su, C.-Y.; Wong, C.-H. J. Am. Chem. Soc. 2007 , 129 , 11892–11893. Synthesis of Tamiflu and its Phosphonate Congeners Possessing Potent Anti-Influenza Activity.
186.	Yang, M.-C.; Fang, J.-M.; Kuo, T.-F.; Wang, D.-M.; Huang, Y.-L.; Liu, L.-Y.; Chen, P.-H.; Chang, T.-H. J. Agric. Food Chem. 2007 , 55 , 8851–8856. Production of Antibodies for Selective Detection of Malachite Green and the Related Triphenylmethane Dyes in Fish and Fishpond Water.
185.	Chen, C.-S.; Wu, S.-H.; Wu, Y.-Y.; Fang, J.-M.; Wu, T.-H. Org. Lett. 2007 , 9 , 2985–2988 . Properties of Astaxanthin/Ca 2+ Complex Formation in the Deceleration of Cis/Trans Isomerization.
184.	Chen, C.-S.; Yu, Y.-P.; Hsu, C.-H.; Wu, Y.-T.; Zou, W.; Fang, J.-M.; Wu, S.-H. Eur. J. Org. Chem. 2007 , 3648–3654. Conformation of Tri-Sialic Acid Lactone. NMR Spectroscopic Analysis and Molecular Dynamics Simulation.
183.	Huang, N.-K.; Chern, Y.; Fang, J.-M.; Lin, C.-I; Chen, W.-P.; Lin, Y.-L. J. Nat. Prod. 2007 , 70 , 571–574. *Neuroprotective Principles from Gastrodia elata* .**
182.	Lin, C.-I; Selvi, S.; Fang, J.-M.; Chou, P.-T.; Lai, C.-H.; Cheng, Y.-M. J. Org. Chem. 2007 , 72 , 3537–3542. Pyreno[2,1- b ]pyrrole and Bis(pyreno[2,1- b ]pyrrole) as Selective Chemosensors of Fluoride Ion: A Mechanistic Study.
181.	Shie, J.-J.; Fang, J.-M. J. Org. Chem. 2007 , 72 , 3141–3144. Microwave Assisted One-Pot Tandem Reactions for the Direct Conversion of Primary Alcohols and Aldehydes to Triazines and Tetrazoles in Aqueous Media.
180.	Yang, S.-M.; Fang, J.-M. Tetrahedron 2007 , 63 , 1421–1428. Synthesis of Polycyclic and 4,5-Diacyl Thiophene-2-carboxylates via Intramolecular Friedel–Crafts Alkylations and Unusual Autooxidative Fragmentation of the Derivatives Obtained from the Samarium Diiodide Promoted Coupling Reactions of Thiophene-2-carboxylate with Carbonyl Compounds.
179.	Lu, S.-H.; Selvi, S.; Fang, J.-M. J. Org. Chem. 2007 , 72 , 117–122. Ethynyl-Linked (Pyreno)Pyrrole–Naphthyridine and Aniline–Naphthyridine Molecules as Fluorescent Sensors of Guanine via Multiple Hydrogen Bondings.
178.	Liao, J.-H.; Chen, C.-T.; Fang, J.-M. J. Chin. Chem. Soc. 2006 , 53 , 1439–1446. Hexaamide Molecule Annexed with Pyrenes for Selective Detection of Phosphate and Pyrophosphate Ions by Ratiometric Fluorescence Changes.
177.	Sun, Y.-Y.; Liao, J.-H.; Fang, J.-M.; Chou, P.-T.; Shen, C.-H.; Hsu, C.-W.; Chen, L.-C. Org. Lett. 2006 , 8 , 3713–3716. Fluorescent Organic Nanoparticles of Benzofuran–Naphthyridine Linked Molecules: Formation and Fluorescence Enhancement in Aqueous Media.
176.	Chien, C.-H.; Chang, J.-C.; Yeh, C.-Y.; Lee, G.-H.; Fang, J.-M.; Song, Y.; Peng, S.-M. Dalton Trans. 2006 , 3249-3256. Weak Antiferromagnetic Coupling for Novel Linear Hexanuclear Nickel(II) String Complexes (Ni 6 12+ ) and Partial Metal–Metal Bonds in Their One-Electron Reduction Products (Ni 6 11+ ).
175.	Chien, C.-H.; Chang, J.-C.; Yeh, C.-Y. ; Lee, G.-H.; Fang, J.-M.; Peng, S.-M. Dalton Trans. 2006 , 2106–2113. Novel Linear Hexanuclear Cobalt String Complexes (Co 6 12+ ) and One-Electron Reduction Products (Co 6 11+ ) Supported by Four Bpyany 2- Ligands.
174.	Wu, C.-Y.; King, K.-Y.; Kuo, C.-J.; Liang, P.-H.; Wu, Y.-T.; Ho, M.-Y.; Liao, C.-L.; Fang, J.-M.; Wong, C.-H. Chem. Biol. 2006 , 13 , 261–268. Stable Benzotriazole Esters as Mechanism-Based Inactivators of the Severe Acute Respiratory Syndrome 3CL Protease.
173.	Cheng, M.-F.; Yu, H.-M.; Ko, B.-W.; Chang, Y.; Chen, M.-Y.; Ho, T.-I.; Tsai, Y.-M.; Fang, J.-M. Org. Biomol. Chem. 2006 , 4 , 510–518. Practical Synthesis of Potential Endothelin Receptor Antagonists of 1,4-Benzodiazepine-2,5-dione Derivatives Bearing Substituents at the C 3 -, N 1 - and N 4 -Positions.

PATENTS:

5.     林啟萬、李政隆、莊榮輝、林世明、李世光、朱瑞民、王金和、方俊民、莊琮亮「光波導型表面電漿共振感測裝置」，中華民國專利申請，2007年。Optical Waveguide Surface Plasma Resonance Sensor, US patent application, 2008.

6.     Chern, Y.; Lin, Y.-L.; Huang, N.-K.; Lin, J.-H.; Fang, J.-M.; Lin, C.-I. “Method of Making and Using an Adenosine Analogue”, US patent 8,129,357 issued on March 6, 2012. 陳儀莊、林雲蓮、黃乃瑰、林榮信、方俊民、林佳誼【腺?類似物的製造及使用方法】China patent CN10152436 1B issued on July 4, 2012.

7.     Wong, C.-H.; Fang, J.-M.; Shie, J.-J.; Cheng, Y.-S. E.; Jan, J.-T. “Synthesis of Oseltamivir Containing Phosphonate Congeners with Anti-influenza Activity”, US patent 7,888,337B2 issued on February 15, 2011, and PCT patent application on August 29, 2008.
8.     Wong, C.-H.; Cheng, Y.-S.; Yu, H.-M.; Cheng, T.-J.; Wu, C.-Y.; Fang, J.-M. “Compositions and Methods for Treating Inflammation and Inflammation-Related Disorders by Plectranthus amboinicus Extracts”, US patent 8105636B2 issued on January 31, 2012.

9.     Wong, C.-H.; Yang, W.-B.; Cheng, T.-J.; Hsieh, Y. S.-Y.; Chien, C.; Lin, C.-C.; Wen, H.-Y.; Fang, J.-M. “Structure and Bioactivity of the Polysaccharides and Oligomers in Medicinal Plant Dendrobium huoshanense”, US patent allowed on June 22, 2012. PCT patent application, 2009, and Taiwan patent application, 2009.

10.   Lin, Y.-L.; Chern, Y.; Fang, J.-M.; Lin, J.-H.; Huang, N.-K. “Dual Functional Adenosine Analogues and Use Thereof in Treating Neurodegenerative Disease”, US and PCT patent applications, 2010.

11.   Wong, C.-H.; Fang, J.-M.; Cheng, Y.-S. E.; Cheng, T.-J. R.; Shie, J.-J. “Zanamivir Phosphonate Congeners with Anti-Influenza Activity and Determining Oseltamivir Susceptibility of Influenza Viruses”, US and PCT patent applications, 2011.

12.   Chang, Z.-F.; Fang, J.-M.; Hu, C.-M.; Yeh, M.-T. “Targeting Human Thymidylate Kinase Induces DNA Repair Toxicity in Malignant Tumor Cells”, US and PCT patent applications, 2011; China and Taiwan patent applications, 2012.

OTHES:

9. 謝俊結、方俊民，「流感藥物的設計與發展」， The Development of Anti-Influenza Drugs: Rational Design of Neuraminidase Inhibitors, Chemistry 2008 , 66 , 279–292.

Publications