Publications
2025
Chang, C.-C., M. Peng, G. D. Keppeke, L.-K. Tsai, Z. Zhang, L.-M. Pai, L.-Y. Sung, and J.-L. Liu. Y12C mutation disrupts IMPDH cytoophidia and alters cancer metabolism. FEBS J. 2025 Apr 5 | PDF |
Wong, S.-S., J. M. Monteiro, C.-C. Chang, M. Peng, N. Mohamad, T. L. Steinacker, B. Xiao, S. Saurya, A. Wainman, and J. W. Raff. Centrioles generate two scaffolds with distinct biophysical properties to build mitotic centrosomes. Sci. Adv. 2025 Feb 7 | PDF |
2024
Chang, C.-C., M. Peng, L.-K. Tsai, C.-C. Chang, C.-J. Li, C.-K. Wu, C.-C. Chien, J. Xu, Z. P. Nagy, C.-H. Liu, C.-H. Lu, and L.-Y. Sung. Sperm penetration at the maturing metaphase I stage can trigger oocyte activation in a mouse model. Reprod. Biomed. Online 2024 Aug | PDF |
Peng, M., G. D. Keppeke, L.-K. Tsai, C.-C. Chang, J.-L. Liu, and L.-Y. Sung. The IMPDH cytoophidium couples metabolism and fetal development in mice. Cell. Mol. Life Sci. 2024 May 08 | PDF |
Li, C.-J., C.-C. Chang, L.-K. Tsai, M. Peng, W.-N. Lyu, J.-F. Yu, M.-H. Tsai, and L.-Y. Sung. Generation of induced pluripotent stem cells from Bornean orangutans. Front. Cell Dev. Biol. 2024 Jan 05 | PDF |
2023
Tsai, L.-K., M. Peng, C.-C. Chang, L. Wen, L. Liu, X. Liang, Y. E. Chen, J. Xu, and L.-Y. Sung. ZSCAN4 interacts with PARP1 to promote DNA repair in mouse embryonic stem cells. Cell Biosci. 2023 Oct 24 | PDF |
Lu, G.-M., H.-H. Hu, C.-C. Chang, J. Zhong, X. Zhou, C.-J. Guo, T. Zhang, Y.-L. Li, B. Yin, and J.-L. Liu. Structural basis of human PRPS2 filaments. Cell Biosci. 2023 May 30 | PDF |
Keppeke, G. D., C.-C. Chang, Z. Zhang, and J.-L. Liu. Effect on cell survival and cytoophidium assembly of the adRP-10-related IMPDH1 missense mutation Asp226Asn. Front. Cell Dev. Biol. 2023 Sep 04 | PDF |
2022
Chang, C.‑C., and J.‑L. Liu. What can asymmetrical cell snakes do? BioEssays 2022 Oct 17 | PDF |
Chang, W.-F., T.-Y. Lin, M. Peng, C.-C. Chang, J. Xu, H.-M. Hsieh‑Li, J.-L. Liu, and L.-Y. Sung. Survival motor neuron enhances pluripotent gene expression and facilitates cell reprogramming. Stem Cells Dev. 2022 Jul 14 | PDF |
Chang, C.‑C., M. Peng, J. Zhong, Z. Zhang, G. D. Keppeke, L.‑Y. Sung, and J.‑L. Liu. Molecular crowding facilitates bundling of IMPDH polymers and cytoophidium formation. Cell. Mol. Life Sci. 2022 Jun 21 | PDF |
Zhong, J., C.-J. Guo, X. Zhou, C.-C. Chang, B. Yin, T. Zhang, H.-H. Hu, G.-M. Lu, and J.-L. Liu. Structural basis of dynamic P5CS filaments. eLife 2022 Mar 14 | PDF |
Hu, H.‑H., G.-M. Lu, C.‑C. Chang, Y. Li, J. Zhong, C.-J. Guo, X. Zhou, B. Yin, T. Zhang, and J.‑L. Liu. Filamentation modulates allosteric regulation of PRPS. eLife 2022 Jun 23 | PDF |
2021
Keppeke, G. D., C.-C. Chang, C. L. Antos, M. Peng, L.-Y. Sung, L. E. C. Andrade, and J.-L. Liu. IMPDH forms the cytoophidium in zebrafish. Dev. Biol. 2021 May 18 | PDF |
Chang, C.-C., G. D. Keppeke, C. L. Antos, M. Peng, L. E. C. Andrade, L.-Y. Sung, and J.-L. Liu. CTPS forms the cytoophidium in zebrafish. Exp. Cell Res. 2021 Jun 1 | PDF |
Peng, M., C.-C. Chang, J.-L. Liu, and L.-Y. Sung. CTPS and IMPDH form cytoophidia in developmental thymocytes. Exp. Cell Res. 2021 May 15 | PDF |
Zhou, X.-L., C.-C. Chang, and J.-L. Liu. Inosine 5′-monophosphate dehydrogenase cytoophidia neighbor insulin granules in pancreatic β cells. Pancreas 2021 Aug 1 | PDF |
Zhou, X., C.-J. Guo, C.-C. Chang, J. Zhong, H.-H. Hu, G.-M. Lu, and J.-L. Liu. Structural basis for ligand binding modes of CTP synthase. Proc. Natl. Acad. Sci. U.S.A. 2021 Jul 23 | PDF |
2019
Zhou, X., C.-J. Guo, H.-H. Hu, J. Zhong, Q. Sun, D. Liu, S. Zhou, C.-C. Chang, and J.-L. Liu. Drosophila CTP synthase can form distinct substrate- and product-bound filaments. J. Genet. Genomics 2019 Nov 20 | PDF |
2018
Chang, C.-C., G. D. Keppeke, L.-Y. Sung, and J.-L. Liu. Interfilament interaction between IMPDH and CTPS cytoophidia. FEBS J. 2018 Aug 1 | PDF |
Lin, W.-C., A. Chakraborty, S.-C. Huang, P.-Y. Wang, Y.-J. Hsieh, K.-Y. Chien, Y.-H. Lee, C.-C. Chang, H.-Y. Tang, Y.-T. Lin, C.-S. Tung, J.-D. Luo, T.-W. Chen, T.-Y. Lin, M.-L. Cheng, Y.-T. Chen, C.-T. Yeh, J.-L. Liu, L.-Y. Sung, M.-S. Shiao, J.-S. Yu, Y.-S. Chang, and L.-M. Pai. Histidine-dependent protein methylation is required for compartmentalization of CTP synthase. Cell Rep. 2018 Sep 4 | PDF |
Keppeke, G. D., C.-C. Chang, M. Peng, L.-Y. Chen, W.-C. Lin, L.-M. Pai, L. E. C. Andrade, L.-Y. Sung, and J.-L. Liu. IMP/GTP balance modulates cytoophidium assembly and IMPDH activity. Cell Div. 2018 Jun 15 | PDF |
2017
Chang, C. C., Y.-M. Jeng, M. Peng, G. D. Keppeke, L.-Y. Sung, and J.-L. Liu CTP synthase forms the cytoophidium in human hepatocellular carcinoma. Exp. Cell Res. 2017 Oct 25 | PDF |
2016
Chang, C.-C., W.-F. Chang, J. Xu, A.-S. Cheng, C.-C. Chang, Z. P. Nagy, C.-C. Yang, S.-T. Ding, and L.-Y. Sung. Production of Live Offspring from Vitrified‑Warmed Oocytes Collected at Metaphase I Stage. PLoS One 2016 Jun 22 | PDF |
2015
Chang, C.-C., W.-C. Lin, L.-M. Pai, H.-S. Lee, S.-C. Wu, S.-T. Ding, J.-L. Liu, and L.-Y. Sung. Cytoophidium assembly reflects upregulation of IMPDH activity. J. Cell Sci. 2015 Oct 1 | PDF |
2014
Chang, W.-F., J. Xu, C.-C. Chang, S.-H. Yang, H.-Y. Li, H.-M. Hsieh‑Li, M.-H. Tsai, S.-C. Wu, W. T. K. Cheng, J.-L. Liu, and L.-Y. Sung. SMN is required for the maintenance of embryonic stem cells and neuronal differentiation in mice. Brain Struct. Funct. 2014 Mar 17 | PDF |
Sung, L.-Y., W.-F. Chang, Q. Zhang, C.-C. Liu, J.-Y. Liou, C.-C. Chang, H. Ou‑Yang, R. Guo, H. Fu, W. T. K. Cheng, S.-T. Ding, C.-M. Chen, M. Okuka, D. L. Keefe, Y. E. Chen, L. Liu, and J. Xu. Telomere elongation and naive pluripotent stem cells achieved from telomerase haplo‑insufficient cells by somatic cell nuclear transfer. Cell Rep. 2014 Dec 11 | PDF |
Aughey, G. N., S. J. Grice, Q.-J. Shen, Y. Xu, C.-C. Chang, G. Azzam, P.-Y. Wang, L. Freeman‑Mills, L.-M. Pai, L.-Y. Sung, J. Yan, and J.-L. Liu. Nucleotide synthesis is regulated by cytoophidium formation during neurodevelopment and adaptive metabolism. Biol. Open 2014 Oct 17 | PDF |
Gou, K.-M., C.-C. Chang, Q.-J. Shen, L.-Y. Sung, and J.-L. Liu. CTP synthase forms cytoophidia in the cytoplasm and nucleus. Exp. Cell Res. 2014 Feb 3 | PDF |
Xiao, G.-Y., I.-H. Liu, C.-C. Cheng, C.-C. Chang, Y.-H. Lee, W. T.-K. Cheng, and S.-C. Wu. Amniotic fluid stem cells prevent follicle atresia and rescue fertility of mice with premature ovarian failure induced by chemotherapy. PLoS One 2014 Sep 8 | PDF |
2012
Cheng, C.-C., W.-S. Lian, F. S.-H. Hsiao, I-H. Liu, S.-P. Lin, Y.-H. Lee, C.-C. Chang, G.-Y. Xiao, H.-Y. Huang, C.-F. Cheng, W. T.-K. Cheng, and S.-C. Wu. Isolation and characterization of novel murine epiphysis derived mesenchymal stem cells. PLoS ONE 2012 Apr 27 | PDF |