Publication | Chun-Hua Hsu Lab

研究發表

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以下為近期代表性論文：

2. Yung-Lin Wang, Li-Ci Ye, San-Chi Chang, Sheng-Chia Chen*, and Chun-Hua Hsu* (2025, Jan). Structural Insight into the Poly(3-hydroxybutyrate) Hydrolysis by Intracellular PHB Depolymerase from Bacillus thuringiensis. International Journal of Biological Macromolecules, 284(1), 137999.

3. Gloria Meng-Hsuan Lin, Tsun-Ai Yu, Chi-Fon Chang, and Chun-Hua Hsu* (2024, May). Proline Isomerization and Molten Globular Property of TgPDCD5 Secreted from Toxoplasma gondii Confers Its Regulation of Heparin Sulfate Binding. JACS Au, 4(5), 1763-1774. (Featured on cover)

4. Yuan-Chao Lou, Cheng-Fen Tu, Chun-Chi Chou, Hsin-Hong Yeh, Chia-Yu Chien, Sushant Sadotra, Chinpan Chen, Ruey-Bing Yang* and Chun-Hua Hsu* (2024, Jan). Structural Insights into the Role of N-Terminal Integrity in PhoSL for Core-Fucosylated N-Glycan Recognition. International Journal of Biological Macromolecules, 255, 128309.

5. Athika Darumas Putria, Ming-Jen Hsu, Chia-Li Han, Fang-Ching Chao, Chun- Hua Hsu, Christian D. Lorenz, and Chien-Ming Hsieh* (2023, Nov). Differential Cellular Responses to FDA-Approved Nanomedicines: An Exploration of Albumin-Based Nanocarriers and Liposomes in Protein Corona Formation. Nanoscale, 5, 17825-17838.

6. Chiao-Hui Hsieh, Chen-Tsung Huang, Yi-Sheng Cheng, Chun-Hua Hsu, Wen- Ming Hsu, Yun-Hsien Chung, Yen-Lin Liu, Tsai-Shan Yang, Chia-Yu Chien, Yu- Hsuan Lee, Hsuan-Cheng Huang* and Hsueh-Fen Juan* (2023, Oct). Homoharringtonine as a PHGDH Inhibitor: Unraveling Metabolic Dependencies and Developing a Potent Therapeutic Strategy for High-risk Neuroblastoma. Biomedicine & Pharmacotherapy, 166, 115429.

7. Sheng-Chia Chen, Bo-Chen Jiang, Yen-Ju Lu, Chia-Hao Chẳng, Tsung-Han Wu, Sheng-Wei Lin, Hua-Wen Yin, Tzong-Huei Lee* and Chun-Hua Hsu* (2023, Sep). Characterization and Crystal Structures of a Cubebol-producing Sesquiterpene Synthase from Antrodia cinnamomea. Journal of Agricultural and Food Chemistry, 71(35), 13014-13023. (Featured on cover)

8. Chun-Hua Hsu* (2023, May). Crystallographic and Biophysical Analysis of the Fusion Core from SARS‐CoV‐2 Spike Protein. Journal of the Chinese Chemical Society, 70(5), 1208-1218. (Special issue to honor Dr. Yu Wang)

9. Kai-Yin Lo, Yi-Fang Tsai, Chun-Hua Hsu, and Chia-Yin Lee* (2022, Dec). Functional Characterization and Structural Modeling of a Novel Glycine Oxidase from Bariovorax paradoxus Iso1. Applied and Environmental Microbiology, 88(23), e0107722.

10. Murali Mohana Rao Singuru, Yu-Chieh Liao, Gloria Meng-Hsuan Lin, Wei-Tzu Chen, Yu-Hsuan Lin, Ching Tat To, Wei-Ching Liao, Chun-Hua Hsu, and Min-Chieh Chuang* (2022, Nov) Engineered Multivalent DNA Capsules for Multiplexed Detection of Genotoxicants via Versatile Controlled Release Mechanisms. Biosensors and Bioelectronics, 216, 114608.

11. Jangam Vikram Kumar, Tien-Sheng Tseng, Yuan-Chao Lou, Shu-Yi Wei, Tsung- Han Wu, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu*, and Chinpan Chen* (2022, May). Structural Insights into DNA Binding Domain of Vancomycin- resistance-associated Response Regulator in Complex with Its Promoter DNA from Staphylococcus aureus. Protein Science, 31(5), e4286.

12. Chun-Chi Chou, Kuo-Tai Hua, Min-Wei Chen, Chin-Jui Wu, Chun-Hua Hsu, Jann-Tay Wang, Michael Hsiao, and Lin-Hung Wei* (2022, Feb). Discovery and Characterization of a Monoclonal Antibody Targeting a Conformational Epitope of IL-6/IL-6Rα to Inhibit IL-6/ IL-6Rα/gp130 Hexameric Signaling Complex Formation. mAbs, 14(1), e2029675.

13. Yi-Chih Chiu, Mei-Chun Tseng, and Chun-Hua Hsu* (2021, Sep). Expanding the Substrate Specificity of Macro Domains toward 3”-isomer of O-Acetyl-ADP- ribose. ACS Catalysis, 11(17), 11075-11090.(Featured on cover)

14. Yi-Chih Chiu, Ting-Syuan Hsu, Chen-Yu Huang, and Chun-Hua Hsu* (2021, Aug). Structural and Biochemical Insights into a Hyperthermostable Urate Oxidase from Thermobispora bispora for Hyperuricemia and Gout Therapy. International Journal of Biological Macromolecules, 188, 914-923.

15. Sheng-Chia Chen, Li-Ci Ye, Te-Ming Yen, Ruei-Xin Zhu, Cheng-Yu Li, San-Chi Chang, Shwu-Huey Liaw*, and Chun-Hua Hsu* (2021, Jul). Crystal Structures of Aspergillus oryzae Rib2 Deaminase: the Functional Mechanism Involved in Riboflavin Biosynthesis. IUCrJ, 8(Pt 4):549-558.

16. Yi-Chih Chiu, Ting-Syuan Hsu, Chen-Yu Huang, and Chun-Hua Hsu* (2021, May). Molecular Elucidation of a Urate Oxidase from Deinococcus radiodurans for Hyperuricemia and Gout Therapy. International Journal of Molecular Sciences, 22(11):5611.

17. Meng-Hsuan Lin, Yi-Ping Huang, Chi-Fon Chang*, and Chun-Hua Hsu* (2021, Apr). NMR Assignments of the Macro Domain from Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). Biomolecular NMR Assignments, 15: 137-142.

18. Sushant Sadotra, Yuan-Chao Lou, Hao-Cheng Tang, Yi-Chih Chiu, Chun-Hua Hsu*, and Chinpan Chen* (2021, Mar). Structural Basis for Promoter DNA Recognition by the Response Regulator OmpR. Journal of Structural Biology, 213(1): 107638.

19. Meng-Hsuan Lin, Chao-Cheng Cho, Yi-Chih Chiu, Chia-Yu Chien, Yi-Ping Huang, Chi-Fon Chang, and Chun-Hua Hsu* (2021, Jan). Elucidating the Tunability of Binding Behavior for the MERS-CoV Macro Domain with NAD Metabolites. Communications Biology, 4, 123.

20. Meng-Hsuan Lin, San-Chi Chang, Yi-Chih Chiu, Bo-Chen Jiang, Tsung-Han Wu, and Chun-Hua Hsu* (2020, Nov). Structural, Biophysical and Biochemical Elucidation of the SARS-CoV-2 Nonstructural Protein 3 Macro Domain. ACS Infectious Diseases, 6(11), 2970–2978. (Featured on cover)

21. Meng-Hsuan Lin, Po-Chih Kuo, Yi-Chih Chiu, Yu-Yung Chang, Sheng-Chia Chen, and Chun-Hua Hsu* (2020, Oct). The Crystal Structure of Protein- transporting Chaperone BCP1 from Saccharomyces cerevisiae. Journal of Structural Biology, 212(1), 107605.

22. Meng-Hsuan Lin, Tsun-Ai Yu, Chi-Fon Chang, Yoshifumi Nishikawa, and Chun- Hua Hsu* (2020, Oct). NMR Resonance Assignments of the Programmed Cell Death Protein 5 (PDCD5) from Toxoplasma gondii. Biomolecular NMR Assignments, 14(2), 277-280.

23. Sarita Aryal, Hong-Ming Hsu, Yuan-Chao Lou, Chien-Hsin Chu, Jung-Hsiang Tai, Chun-Hua Hsu*, and Chinpan Chen* (2020, Sep). N-terminal Segment of TvCyP2 Cyclophilin from Trichomonas vaginalis is Involved in Self-association, Membrane Interaction and Subcellular Localization. Biomolecules, 10(9), 1239.

24. Yu-Yung Chang, Sora Hagawa, and Chun-Hua Hsu* (2020, Sep). Adaptation of Thermophilic Acetyltransferase to Water-mediated Catalytic Mechanism. Chemical Communications, 56, 10537-10540.

25. Tsai-Mu Cheng, Rou Li, Yu-Chieh Jill Kao, Chun-Hua Hsu, Hsueh-Liang Chu, Kun-Ying Lu, Chun A. Changou, Che-Chang Chang, Lee-Hsin Chang, Min-Lang Tsai, Fwu-Long Mi (2020, Sep). Synthesis and characterization of Gd- DTPA/fucoidan/peptide complex nanoparticle and in vitro magnetic resonance imaging of inflamed endothelial cells. Materials Science and Engineering: C, 10(9), 1239.

26. Sheng-Chia Chen, Szu-Pei Wu, Yu-Yung Chang, Tzann-Shun Hwang, Tzong- Huei Lee* and Chun-Hua Hsu* (2020, Jun). Crystal Structure of α-galactosidase from Thermus thermophilus: Insight into Hexamer Assembly and Substrate Specificity. Journal of Agricultural and Food Chemistry, 68(22),6161-6169. (Featured on cover)

27. Bor-Chyuan Su, Tsung-Han Wu, Chun-Hua Hsu, and Jyh-Yih Chen* (2020, Jan). Distribution of Positively Charged Amino Acid Residues in Antimicrobial Peptide Epinecidin-1 is Crucial for in vitro Glioblastoma Cytotoxicity and its Underlying Mechanisms. Chemico-Biological Interactions, 315:108904.

28. Yuan‐Chao Lou, Chun‐Chi Chou, Hsin‐Hong Yeh, Chia‐Yu Chien, Sushant Sadotra, Chun‐Hua Hsu*, and Chinpan Chen* (2020, Jan). Structural Basis for −35 Element Recognition by σ4‐chimera Proteins and Their Interactions with PmrA Response Regulator. Proteins: Structure, Function and Bioinformatics, 88(1):69-81.

29. Fang-Fang Chen, Chia-Yu Chien, Chao-Cheng Cho, Yu-Yung Chang, and Chun- Hua Hsu* (2019, Oct). C-terminal Redox Domain of Arabidopsis APR1 is a Non-canonical Thioredoxin Domain with Glutaredoxin Function. Antioxidants, 8(10): 461.

30. Yi-Chieh Chou, Chia-I Shih, Chih-Chia Chiang, Chun-Hua Hsu, and Yi-Chun Yeh* (2019, Oct). Reagent-free DOPA-dioxygenase Colorimetric Biosensor for Selective Detection of L-DOPA. Sensors & Actuators: B. Chemical, 297, 126717.

31. Dan-Chu Chin, Rajendran Senthil Kumar, Ching-Shu Suen, Chia-Yu Chien, Ming-Jing Hwang, Chun-Hua Hsu, Xu Xuhan, Zhong Xiong Lai, and Kai-Wun Yeh* (2019, Jun). Plant Cytosolic Ascorbate Peroxidase with Dual Catalytic Activity Modulates Abiotic Stress Tolerances. iScience, 16, 31-49.