賴亮全教授

Lab topic

Our major research interests are using microarray or next generation sequencing to explore cancer genomics. We investigate gene expression profiling, copy number variation, single nucleotide polymorphism, epigenetics and microRNA in lung, breast and esophageal cancers.

Recently, we identified several semaphorin gene family members as potential therapeutic targets, and found that SEMA5A may be a useful prognostic biomarker for non-smoking women with non-small cell lung carcinoma.

Research topics

Regulatory mechanism of NDRG1 upon reoxygenation

Hypoxic tumors are more resistant to therapy and have worse prognosis, yet oxygen concentration within tumors is highly variable. We investigate how NDRG1 helps tumor cells adapt to fluctuating oxygen concentrations through transcription factors, microRNAs, promoter methylation, and functional assays in vitro and in vivo.

Semaphorin family in lung cancer

We investigate the roles of SEMA genes in lung carcinogenesis using gene over-expression, genomic analysis and athymic nude mouse models. Understanding their effects on cell migration and adhesion may contribute to more specific therapeutic strategies.