Publications (1991-2000):

1. Chien, C.L., Y.P. Chau, and K.S. Lu. 1991. Ultrastructural studies on the barrier properties of the paraganglia in the rat recurrent laryngeal nerve. Acta Anat. 141:262-268.

2. Chau, Y.P., C.L. Chien, and K.S. Lu. 1991. The permeability of capillaries among the small granule-containing cell in rat superior cervical ganglia: an ultrastructural lanthanum tracer study. Histol. Histopathol. 6:261-268.

3. Lu, K.S., C.L. Chien, and Y.P. Chau. 1992. Effects of 5-hydroxydopamine and 6-hydroxydopamine on the ultrastructure of Type I cells in paraganglia of the rat recurrent laryngeal nerve. Arch. Histol. Cytol. 55:57-65.

4. Chien, C.L. and R.K.H. Liem. 1994. Characterization of  the mouse gene encoding the neuronal intermediate filament protein, alpha-internexin. Gene 149:289-292.

5. Chien, C.L. and R.K.H. Liem. 1995. The neuronal intermediate filament, alpha-internexin is transiently expressed in amacrine cells in the developing mouse retina. Exp. Eye Res. 61:749-756.

6. Chien, C.L., C.A. Mason, and R.K.H. Liem. 1996. alpha-internexin is the only neuronal intermediate filament expressed in developing cerebellar granule neurons. J. Neurobiol. 29:304-318.

7. Wang, S.M., T.H Fong, S.Y. Hsu, C.L. Chien and J.C. Wu. 1997. Reorganization of a novel vimentin-associated protein in 3T3-L1 cells during adipose conversion. J. Cellular Biochem. 67:84-91.

8. Wei, H.J., T.H. Su, C.L. Chien, and C.R. Tzeng. 1997. Florescence in situ hybridization (FISH) as a method to detect aneuploid cells. Fetal Diagn. Ther. 12:309-313.

9. Pekny M., C. Eliasson, C.L. Chien, L.G. Kindblom, R. Liem, A. Hamberger, and C. Betsholtz. 1998. GFAP-deficient astrocytes are capable of stellation in vitro when cocultured with neurons and exhibit a reduced amount of intermediate filaments and an increased cell saturation density. Exp. Cell Res. 239:332-343.

10. Ho, C.L., C.L. Chien, K. Brown, and R.K.H. Liem. 1998. Studies of carboxyl-terminal truncation mutants of the neuronal intermediate filament protein, peripherin. J. Neurochem. 70:1916-1924.

11. Chien, C.L.*, T.H. Lee, and K.S. Lu. 1998. The distribution of neuronal intermediate filament proteins in the developing mouse olfactory system. J. Neurosci. Res. 54:353-363.

12. Ching, G.Y., C.L. Chien, R. Flores, and R.K.H. Liem. 1999. Overexpression of alpha-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice. J. Neurosci. 19:2974-2986.

13. Shih S.C., C.L. Chien, K.W. Tseng, S.C. Lin, and C.R. Kao. 1999. Immunohistochemical studies of transforming growth factor-β and its receptors in the gastric mucosa of patients with refractory gastric ulcer. J. Formosan Medical Assoc. 98:613-620.

14. Yang, M.F., C.L. Chien, and K.S. Lu. 1999. Morphological, immunohistochemical and quantitative studies of murine brain mast cells after mating. Brain Res. 846:30-39.

Publications (2001-2005)

15. Chou HC, Chien CL, Huang HL, and Lu KS. Effects of zinc deficiency on the vallate papillae and taste buds in rats. J. Formos. Med. Assoc. 2001; 100:326-335.

16. Chou HC, Chien CL, and Lu KS. The distribution of PGP9.5, BDNF and NGF in the vallate papilla of adult and developing mice. Anat. Embryol. 2001; 204:161-169.

17. Chien CL*, Wang P, Yin HS, Lue JH, Wu JC, Hsieh ST, and Lu KS. Evaluation of anatomy course from the students of allied health sciences. J. Med. Education 2001; 5:124-134.

18. Yang MF, Chien CL, and Lu KS. Compound 48/80-induced degranulation of GnRH-like immunoreactive mast cells in the brain and mesentry of the gerbil. Zool. Stud. 2002; 41:99-110.

19. Chien CL*, Chen TW, Lin YS, and Lu KS. The Apoptotic Process of Human Bladder Carcinoma T24 Cells Induced by Retinoid. J. Biomed. Sci. 2004; 11:631-640.

20. Chen SC, Huang CC, Chien CL, Jeng CJ, Su HT, Chiang E, Liu MR, Wu CH, Chang CN, and Lin RH. Cross-linking of p-selectin glycoprotein ligand-1 induced death of activated T cells. Blood 2004; 104:3233-3242.

21. Lee HH, Chien CL, Liao HK, Chen YJ, and Chang ZF. Nuclear efflux of heterogeneous nuclear ribonucleoprotein C1/C2 in apoptotic cells: a novel nuclear export dependent on Rho-associated kinase activation. J. Cell Sci. 2004; 117:5579-5589.

22. Wang P, Yin HS, Lue JH, Wu JC, Hsieh ST, and Chien CL*. The evaluation of anatomy course provided for the nursing students. J. Med. Education 2004; 8:78-86

23. Yang KT, Pan SF, Chien CL, Hsu SM, Tseng YZ, Wang SM, and Wu ML. Mitochondrial Na+ overload is caused by oxidative stress and leads to activation of the caspase 3- dependent apoptotic machinery. FASEB J. 2004; 18:1442-4.

24. Shih SC, Tseng KW, Lin SC, Kao CR, and Chien CL*. Expression patterns of transforming growth factor-beta and its receptors in the gastric mucosa of patients with refractory gastric ulcer. World J. Gastroenterol. 2005; 11:136-141.

25. Yu MF, Chien CL, Lee WT, and Yin HS. Effects of amphetamine on the AMPA-mediated synaptic activity and the expression of AMPA receptor subunit 2 of brain neurons. J. Mol. Neurosci. 2005; 25:171-181.

26. Chien CL*, Liu TC, Ho CL, and Lu KS. Overexpression of neuronal intermediate filament protein internexin in PC 12 cells. J. Neurosci. Res. 2005; 80:693-706.

27. Chien CL, Chen YC, Chang MF, Greenberg AS, and Wang SM. Magnolol induces the distribvutional changes of p160 and adipose differentiation-related protein in adrenal cells. Histochem. Cell Biol. 2005; 123:429-439.

28. Chiang PC, Chien CL, Pan SL, Chen WP, Teng CM, Shen YC, and Guh JH. Induction of endoplasmic reticulum stress and apoptosis by a marine prostanoid in human hepatocellular carcinoma. J. Hepatol. 2005; 43:679-686.

29. Yen ML, Su JL, Chien CL, Tseng KW, Yang CY, Chen WF, Chang CC, and Kuo ML. Diosgenin induces HIF-1 activation and angiogenesis through estrogen receptor-related PI3K/Akt and p38 MAPK pathways in osteoblasts. Mol. Pharmacol. 2005; 68:1061-1073.

30. Chien CL*, Lu KS, Lin YS, Hsieh CJ, and Hirokawa N. The functional Cooperation of MAP1A Heavy Chain and Light Chain 2 in the Binding of Microtubules. Exp. Cell Res. 2005; 308:446-458.

31. Ko TL, Chien CL, and Lu KS. The expression of α-internexin and peripherin in the developing mouse pineal gland. J. Biomed. Sci. 2005; 12:777-789.

32 Huang DM, Hung Y, Ko BS, Hsu SC, Chen WH, Chien CL, Tsai CP, Kuo CT, Kang JC, Yang CS, Mou CY, and Chen YC. Highly efficient cellular labeling of mesoporous nanoparticles in human mesenchymal stem cells: implication for stem cell tracking. FASEB J. 2005; 19:2014-2016.

Publications 2006-2011

33. Yang KT, Chang WL, Yang PC, Chien CL, Lai MS, Su MJ, and Wu ML*. Activation of the transient receptor potential M2 channel and poly(ADP-ribose) polymerase is involved in oxidative stress-induced cardiomyocyte death. Cell Death Differ. 2006; 13:1815-1826.

34. Wang P, Wang SM, Hsieh CJ, and Chien CL*. Neural expression of α-internexin promoter in vitro and in vivo. J. Cell. Biochem. 2006; 97:275-287.

35. Shih JC, Chien CL*, Ho HN, Lee WC, and Hsieh FJ. Stellate transformation of invasive trophoblast: A distinct phenotype of trophoblast that involves in decidual vascular remodeling and controlled invasion during pregnancy. Hum. Reprod. 2006; 21:1299-1304.

36. Tseng KW, Lu KS, and Chien CL *. A possible cellular mechanism of neuronal loss in the dorsal root ganglia of dystonia musculorum (dt) mice. J. Neuropathol. Exp. Neurol. 2006; 65:336-347.

37. Tseng WC, Lu KS, Lee WC, Chien CL*. Redistribution of GFAP and aB-crystallin after thermal stress in C6 glioma cell line. J. Biomed. Sci. 2006; 13:681-694.

38. Chen SU, Chien CL, Wu MY, Chen TH, Lai SM, Lin CW, Yang YS*. Novel direct cover vitrification (DCV) for cryopreservation of ovarian tissues increases follicle viability and pregnancy capability in mice models. Hum. Reprod. 2006; 21: 2794-2800.

39. Chen HF, Kuo HC, Chien CL, Shun CT, Yao YL, Ip PL, Chuang CY, Wang CC, Yang YS, Ho HN*. Derivation, characterization and differentiation of human embryonic stem cells: comparing serum-containing versus serum-free media and evidences of germ cell differentiation. Hum. Reprod. 2007; 22: 567-577.

40. Kung HN, Chien CL, Chau GY, Don MJ, Lu KS, Chau YP*. Involvement of NO/cGMP signaling in the apoptotic and anti-angiogenic effects of b-lapachone on endothelial cells in vitro. J. Cell. Physiol. 2007; 211:522-532.

41. Yu CY, Chen JY, Lin YY, Shen KF, Lin WL, Chien CL, Ter Beest MB, Jou TS*. A bipartite signal regulates the faithful delivery of apical domain marker Podocalyxin/Gp135. Mol. Biol. Cell 2007; 18:1710-1722.

42. Shyu MK, Yuan RH, Shih JC, Wu MZ, Chen HL, Kuo YC, Chien CL, Chow LP, Chen HL, Hsieh FJ. Kinetics and functional assay of liver repopulation after human cord blood transplantation. Dig. Liver Dis. 2007; 39:455-465.

43. Yeh LK, Liu CY, Chien CL, Converse RL, Kao WW, Chen MS, Hsieh FJ, Wang IJ*. Molecular analysis and characterization of zebrafish keratocan (zKera) gene. .J. Biol. Chem. 2008; 283:506-517.

44. Wang P. Jeng CJ, Chien CL, Wang SM*. Signaling mechanisms of daidzein-induced axonal outgrowth in hippocampal neurons. Biochem. Biophys. Res. Commun. 2008; 366:393-400.

45. Tseng KW, Chau YP, Yang MF, Lu KS, and Chien CL*. Abnormal cellular translocation of α-Internexin in spinal motor neurons of dystonia musculorum mice. J. Comp. Neurol. 2008. 507:1053-1064.

46. Wang SY, Chien CL, Shih SC*. Intercellular Invasion of Helicobacter pylori and Delayed Healing of a Gastric Ulcer. Am. J. Gastroenterol. 2008;103:249-250.

47. Fang KM, Lee AS, Su MJ, Lin CL, Chien CL*, Wu ML*. Free fatty acids act as endogenous ionophores, resulting in Na+ and Ca2+ influx and myocyte apoptosis. Cardiovasc Res. 2008; 78:533-545.

48. Thajeb P*, Wang P, Chien CL, Harrigan R. Novel polymorphisms of the amyloid precursor protein (APP) gene in Chinese/Taiwanese patients with Alzheimer’s disease. J Clin Neurosci. 2009;16:259-63.

49. Chen TY, Chi KH, Wang JS, Chien CL, Lin WW*. Reactive oxygen species are involved in FasL-induced caspase-independent cell death and inflammatory responses. Free Radic Biol Med. 2009; 46:643-655.

50. Huang C, Chang SC, Yang HC, Chien CL and Chang MF*. Clathrin-mediated post-Golgi trafficking in the morphogenesis of hepatitis delta virus. J Virol. 2009; 83:12314-12324.

51. Chen YT*, Furushima K, Hou PS, Ku AT, Deng JM, Jang CW, Fang H, Adams HP, Kuo ML, Ho HN, Chien CL*, and Behringer RR*. PiggyBac transposon-mediated, reversible gene transfer in human embryonic stem cells. Stem Cells Dev. 2010; 19:763-771.

52. Wang NK, Tosi J, Kasanuki JM, Chou CL, Kong J, Parmalee N, Wert KJ, Allikmets R, Lai CC, Chien CL, Nagasaki T, Lin CS, Tsang SH. Transplantation of reprogrammed embryonic stem cells improves visual function in a mouse model for retinitis pigmentosa. Transplantation. 2010; 89:911-999.

53. Chen IY, Chang SC, Wu HY, Yu TC, Wei WC, Lin S, Chien CL, Chang MF*. Upregulation of the chemokine (C-C motif) ligand 2 via a severe acute respiratory syndrome coronavirus spike-ACE2 signaling pathway. J Virol. 2010; 84:7703-12.

54. Chen HF, Kuo HC, Lin SP, Chien CL, Chiang MS, Ho HN*. Hypoxic Culture Maintains Self-Renewal and Enhances Embryoid Body Formation of Human Embryonic Stem Cells. Tissue Eng. Part A. 2010; 16:2901-2913.

55. Yeh LK, Liu CY, Kao WW, Huang CJ, Hu FR, Chien CL*, Wang IJ*. Knockdown of zebrafish lumican gene (ZLUM) causes scleral thinning and increased size of scleral coats. J Biol Chem. 2010; 285:28141-28155.

56. Wong CW, Hou PS, Tseng SF, Chien CL, Wu KJ, Chen HF, Ho HN, Kyo S, Teng SC*.. KLF4 Contributes to Maintenance of Telomerase Activity in Stem Cells. Stem Cells. 2010;28:1510-1517.

57. Huang WC, Chen YJ, Chien CL, Kashima H, Lin KC*. Constraint-induced movement therapy as a paradigm of translational research in neurorehabilitation: Reviews and prospects. Am J Transl Res. 2010; 3:48-60.

58. Chen SY, Chiu LY, Ma MC, Wang JS, Chien CL, Lin WW. zVAD-induced autophagic cell death requires c-Src-dependent ERK and JNK activation and reactive oxygen species generation. Autophagy. 2011 Feb 1;7(2):90-101. [Epub ahead of print]

59. Tseng KW, Peng ML, Wen YC, Liu KJ and Chien CL*. Neuronal degeneration in autonomic nervous system of dystonia musculorum mice. J. Biomed. Sci. 2011. (Accepted)