王淑慧 助理教授

   

   Assistant Professor
   College of Medical, National Taiwan University
   Department of Anatomy and Cell Biology
   Room 644

   台北市仁愛路一段一號六樓 (解剖學暨細胞生物學研究所)
    Office Phone: +886-2-23123456 ext. 88180
   Fax: + (886)-2-23915292

 　

      shwang@ntu.edu.tw

 

　

 

　

　

   個人經歷

    台灣大學解剖學暨細胞生物學研究所 博士

    陽明大學醫學院生理學研究所 博士後研究員

    陽明大學醫學院解剖學暨細胞生物學研究所 博士後研究員
     台灣大學解剖學暨細胞生物學科 助理教授

 

   研究專長

    臍帶間質幹細胞分化及其應用於心血管疾病治療的療效與調控機制

　

 

   研究成果

  1. Shu-Huei Wang*, Tse-Ya Yu*, Feng-Chiao Tsai, Chris J. Weston, Mao-Shin Lin3, Chi-Sheng Hung, Hsien-Li Kao, Yu-I Li, Montse Solé, Mercedes Unzeta, Yuh-Lien Chen1, Lee-Ming Chuang, Hung-Yuan Li (2018, Mar). Inhibition of Semicarbazide-sensitive Amine Oxidase Reduces Atherosclerosis in Apolipoprotein E-deficient Mice. Translational research (accepted) 本人為第一作者.

  2. Chin-Chuan Chen, Ju-Sui Huang, Tong-Hong Wang, Chen-Hsin Kuo, Chia-Jen Wang, Shu-Huei Wang*, and Yann-Lii Leu* (2017, Dec). Dihydrocoumarin, an HDAC Inhibitor, Increases DNA Damage Sensitivity by Inhibiting Rad52. International Journal of Molecular Sciences, 18(12), 2655. 本人為通訊作者.

  3. Chin-Chuan Chen, Chun-Pin Kao, Mei-Miao Chiu and Shu-Huei Wang* (2017, Nov). The anti-cancer effects and mechanisms of Scutellaria barbata D. Don on CL1-5 lung cancer cells. Oncotarget, 8:109340-109357. MOST 105-2320-B-002-009. 本人為通訊作者.

  4. Chung-Ju Yeh, Chin-Chuan Chen, Yann-Lii Leu, Ming-Wei Lin, Mei-Miao Chiu, Shu-Huei Wang* (2017, Nov). The effects of artocarpin on wound healing: in vitro and in vivo studies. Scientific Reports, 7(1):15599. MOST 105-2320-B-002-009. 本人為通訊作者.

  5. Chin-Chuan Chen, Chan-Jung Liang, Yann-Lii Leu, Yuh-Lien Chen, Shu-Huei Wang* (2016, Dec). Viscolin Inhibits In Vitro Smooth Muscle Cell Proliferation and Migration and Neointimal Hyperplasia In Vivo. PLoS One, 11(12):e0168092. 本人為通訊作者.

  6. Chin-Chaun Chen, Ming-Wei Lin, Chan-Jung Liang, Shu-Huei Wang* (2016, Jul). The Anti-Inflammatory Effects and Mechanisms of Eupafolin in Lipopolysaccharide-Induced Inflammatory Responses in RAW264.7 Macrophages. PLoS One, 11(7):e0158662. 本人為通訊作者.

  7. Wen-Ching Shen, Chan-Jung Liang, Tao-Ming Huang, Chen-Wei Liu, Shu-Huei Wang, Guang-Huar Young, Jaw-Shiun Tsai, Ying-Chin Tseng, Yu-Sen Peng, Vin-Cent Wu, Yuh-Lien Chen (2015, Dec). Indoxyl sulfate enhances IL-1β-induced E-selectin expression in endothelial cells in acute kidney injury by the ROS/MAPKs/NFκB/AP-1 pathway. Archives of Toxicology, 90(11):2779-2792.

  8. Hsin-Ching Sung, Chan-Jung Liang, Chiang-Wen Lee, Feng-Lin Yeng, Chien-Yu Hsiao, Shu-Huei Wang, Ya-Fen Jiang- Shieh, Jaw-Shiun Tsai, Yuh-Lien Chen (2015, Jul). The protective effect of eupafolin against TNF-α-induced lung inflammation via the reduction of intercellular cell adhesion molecule-1 expression. Journal of Ethnopharmacology, 21;170:136-47.

  9. Shu-Huei Wang, Pei-Ya Lin, Ya-Chen Chiu, Ju-Sui Huang, Yi-Tsen Kuo, Jen-Chine Wu, Chin-Chuan Chen* (2015, Jul). Curcumin-Mediated HDAC Inhibition Suppresses the DNA Damage Response and Contributes to Increased DNA Damage Sensitivity. PLoS One., 10(7):e013410. 本人為第一作者.

  10. Chan-Jung Liang, Wen-Ching Shen, Fu-Bin Chang, Vin-Cent Wu, Shu-Huei Wang, Guang-Huar Young, Jaw-Shiun Tsai, Ying-Chin Tseng, Yu-Sen Peng, Yuh-Lien Chen* (2015, May). Endothelial progenitor cells derived from Wharton's jelly of human umbilical cord attenuate ischemic acute kidney injury by increasing vascularization and decreasing apoptosis, inflammation, and fibrosis. Cell Transplantation, 24(7):1363-77.

  11. Chan-Jung Liang, Chiang-Wen Lee, Hsin-Ching Sung, Yung-Hsiang Chen, Yao-Chang Chiang, Hsien-Yeh Hsu, Ying-Chin Tseng, Chi-Yuan Li, Shu-Huei Wang*, and Yuh-Lien Chen* (2014, Apr). Ganoderma lucidum Polysaccharides Reduce Lipopolysaccharide-Induced Interleukin-1ß Expression in Cultured Smooth Muscle Cells and in Thoracic Aortas in Mice. Evidence-Based Complementary and Alternative Medicine, 2014:305149. 本人為通訊作者.

  12. Chan-Jung Liang, Chiang-Wen Lee, Hsin-Ching Sung, Yung-Hsiang Chen, Shu-Huei Wang, Pei-Jhen Wu, Yao-Chang Chiang, Jaw-Shiun Tsai, Chau-Chung Wu, Chi-Yuan Li, Yuh-Lien Chen (2014). Magnolol Reduced TNF-α-Induced Vascular Cell Adhesion Molecule-1 Expression in Endothelial Cells via JNK/p38 and NF-κB Signaling Pathways . The American Journal of Chinese Medicine, 42(3):619-37.

  13. Chih-Kai Liao, Chung-Jiuan Jeng, Hwai-Shi Wang, Shu-Huei Wang, Jiahn-Chun Wu (2013, Nov). Lipopolysaccharide Induces Degradation of Connexin43 in Rat Astrocytes via the Ubiquitin-Proteasome Proteolytic Pathway.. PLoS One, 8(11):e79350.. (SCI, 15/64, MULTIDISCIPLINARY SCIENCES ).

  14. Chan-Jung Liang, Yu-Hsiu Yen, Ling-Yi Hung, Shu-Huei Wang, Chi-Ming Pu, Hsiung-Fei Chien, Jaw-Shiun Tsai, Chiang-Wen Lee, Feng-Lin Yen, Yuh-Lien Chen* (2013, Jun). Thalidomide inhibits fibronectin production in TGF-β1-treated normal and keloid fibroblasts via inhibition of the p38/Smad3 pathway. Biochemical Pharmacology, 85(11):1594-602..

  15. Wen-Ching Shen, Chan-Jung Liang, Vin-Cent Wu, Shu-Huei Wang, Guang-Huar Young, I-Rue Lai, Chung-Liang Chien, Seu-Mei Wang, Kwan-Dun Wu, and Yuh-Lien Chen* (2013, May). Endothelial progenitor cells derived from Wharton's jelly of the umbilical cord reduces ischemia-induced hind limb injury in diabetic mice by inducing HIF-1α/IL-8 expression. Stem Cells and Development, 22(9):1408-18.

  16. Shu-Huei Wang, Chan-Jung Liang, Yu-Wen Weng, Yung-Hsiang Chen, Hsien-Yeh Hsu, Hsiung-Fei Chien, Jaw-Shiun Tsai, Ying-Chin Tseng, Chi-Yuan Li, Yuh-Lien Chen* (2012, Aug). Ganoderma lucidum Polysaccharides Prevent Platelet-Derived Growth Factor-Stimulated Smooth Muscle Cell Proliferation in vitro and Neointimal Hyperplasia in the Endothelial-Denuded Artery in vivo. J Cell Physiol, 227(8):3063-71. 本人為第一作者.

  17. Jung-Tung Liu, Yuh-Lien Chen, Wen-Chi Chen, Huey-Yi Chen, Yi-Wen Lin, Shu-Huei Wang, Kee-Ming Man, Hui-Min Wan, Wei-Hsian Yin, Po-Len Liu, and Yung-Hsiang Chen (2012, Mar). Role of Pigment Epithelium Derived Factor in Stem Progenitor Cell Associated Neovascularization. Journal of biomedicine & biotechnology, 2012; 2012:871272.

  18. Shu-Huei Wang, Chan-Jung Liang, Jiahn-Chun Wu, Jiuan-Jiuan Huang, Hsiung-Fei Chien, Jaw-Shiun Tsai, Yuh-Siu Yen, Ying-Chih Tseng, June-Horng Lue, Yuh-Lien Chen (2012, Feb). Pigment epithelium-derived factor reduces the PDGF-induced migration and proliferation of human aortic smooth muscle cells through PPAR activation. International Journal of Biochemistry & Cell Biology, 2012; 44(2):280-289. 本人為共同第一作者.

  19. Wan-Ju Hsieh, Chan-Jung Liang, Jen-Jie Chieh, Shu-Huei Wang, I-Rue Lai, Jyh-Horng Chen, Fu-Hsiung Chang, Wei-Kung Tseng, Shieh-Yueh Yang, Chau-Chung Wu, and Yuh-Lien Chen (2012, Jun). In vivo tumor targeting and imaging with anti-vascular endothelial growth factor antibody-conjugated dextran-coated iron oxide nanoparticles. International Journal of Nanomedicine, 2012; 7:2833-2842.

  20. Ruby YunJu Huang, ChenChen Wen, ChihKai Liao, ShuHuei Wang, LiangYin Chou, JiahnChun Wu (2012, Sep). Lysophosphatidic acid modulates the association of PTP1B with N-cadherin/catenin complex in SKOV3 ovarian cancer cells. Cell Biology International, 2012; 36(9):833-841.

  21. Chan-Jung Liang, ShuHuei Wang, Yung-Hsiang Chen, Shih-Sheng Chang, Tong-Long Hwang, Yann-Lii Leu, Ying-Chih Tseng, Chi-Yuan Li, Yuh-Lien Chen (2011, Oct). Viscolin reduces VCAM-1 expression in TNF-α treated endothelial cells via the JNK/NF-κB and ROS pathway. Free Radical Biology and Medicine, 2011; 51(7):1337-1346. 本人為共同第一作者.

  22. Wen-Huey Wu, Shu-Huei Wang, I-I Kuan, Ya-shi Kao, Pei-Jhen Wu, Chan-Jung Liang, Hsiung-Fei Chien, Chiu-Hua Kao, Ching-Jang Huang, Yuh-Lien Chen (2010, Sep). Sesamin attenuates intercellular cell adhesion molecule-1 expression in vitro in TNF-alpha-treated human aortic endothelial cells and in vivo in apolipoprotein-E-deficient mice. Molecular Nutrition & Food Research, 2010; 54(9):1-11.

  23. Ching-Yuang Lin, Yung-Hsiang Chen, Chia-Ying Lin, Hsien-Yeh Hsu, Shu-Huei Wang, Chan-Jung Liang, I-I Kuan, Pei-Jhen Wu, Pei-Ying Pai, Chau-Chung Wu* and Yuh-Lien Chen*(2010, Sep). Ganoderma lucidum polysaccharides attenuate endotoxin-induced intercellular cell adhesion molecule-1 expression in cultured smooth muscle cells and in the neointima in mice. Journal of Agricultural and Food Chemistry, 2010; 58(17):9563-9571.

  24. Shu-Huei Wang, Shing-Jong Lin, Yung-Hsiang Chen, Fen-Yen Lin, Jin-Chung Shih, Chau-Chung Wu, Hua-Lin Wu, Yuh-Lien Chen*(2009, Jun). Late outgrowth endothelial cells derived from Wharton’s jelly in human umbilical cord reduce neointimal formation after vascular injury: involvement of pigment epithelium-derived factor. Arteriosclerosis, Thrombosis, and Vascular Biology, 2009; 29(6):816-822. 本人為第一作者.

  25. Chau-Chung Wu, Shu-Huei Wang, I.-I. Kuan, Wei-Kung Tseng, Ming-Fong Chen, Jiahn-Chun Wu, Yuh-Lien Chen* (2009, Jun). OxLDL upregulates caveolin-1 expression in macrophages: Role for caveolin-1 in the adhesion of oxLDL-treated macrophages to endothelium. Journal of Cellular Biochemistry, 2009; 107(3):460-472.

  26. Shing-Jong Lin, Fang-Yu Hsieh, Yung-Hsiang Chen, Chia-Chi Lin, I-I Kuan, Shu-Huei Wang, Chau-Chung Wu, Hsiung-Fei Chien, Fen-Yen Lin, Yuh-Lien Chen* (2009, Sep). Atorvastatin induces thrombomodulin expression in the aorta of cholesterol-fed rabbits and in TNF alpha-treated human aortic endothelial cells. Histology and Histopathology, 2009; 24(9):1147-1159.

  27. Shing-Jong Lin, Yung-Hsiang Chen, Feng-Yen Lin, Li-Yuan Hsieh, Shu-Huei Wang, Chia-Ying Lin, Yu-Chieh Wang, Hung-Hai Ku, Jaw-Wen Chen, Yuh-Lien Chen* (2007, Jun). Pravastatin induces thrombomodulin expression in TNF alpha-treated human aortic endothelial cells by inhibiting Rac1 and Cdc42 translocation and activity. Journal of Cellular Biochemistry, 2007; 101(3):642-653.

    

 

 

   實驗室成員

        碩士生：陳昱志

        研究助理：顏毓庭

        畢業生：林名薇、鞠沅東、張庭欣

 

   回解剖學暨細胞生物學科

 

 

 

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