真菌生理及分子生物學研究室
 |
專長： |
真菌生理及分子生物 |
實驗室： |
一號館 214 / 216 室 | |
電話： |
02-33664599 | |
傳真： |
02-23636490 | |
E-mail： |
wcshen@ntu.edu.tw | |
| ◆ 人體病原真菌隱球菌致病性、生殖生理及發生分子調控機制之研究。 |
| ◆ 臺灣水稻稻熱病菌族群特性之研究。 |
| ◆植物病原真菌致病性分子調控機制之研究。 |
| ◆ 藥用真菌功能基因體之研究。 |
| ◆ 真菌遺傳 |
| ◆ 真菌生理 |
| ◆ 真菌分子生物 |
| ◆ 真菌訊息傳導 |
| 美國德州農工大學 |
| 國立台灣大學 |
| 國立台灣大學 |
| 國立台灣大學 植物病理與微生物學系 教授 |
| 國立台灣大學 植物病理與微生物學系 副教授 |
| 國立台灣大學 植物病理與微生物學學系 助理教授 |
| 美國杜克大學 博士後研究 |
| ◆ 微生物生理學 |
| ◆ 微生物研究法 |
| ◆ 進階 微生物學 |
| ◆ 微生物學實驗 |
| ◆ 醫用真菌學特論 |
| ◆ 真菌生理學 |
| ◆ 現代分子真菌學 |
| ◆ 植物分子檢測與實驗 (合授) |
| ◆ 生物技術核心實驗 (合授) |
| ◆ 植物病理研究法與實驗 (合授) |
| ◆ 人畜共通傳染病概論 (合授) |
| 期刊論文 | |
01. |
Liu, K.H. and W.C. Shen*. 2011. Mating differentiation in Cryptococcus neoformans is negatively regulated by the Crk1 protein kinase. Fungal Genetics and Biology 48:225-240. |
02. |
Liao, V.H.C., Y.J. Chu, Y.C. Su, S.Y. Hsiao, C.C. Wei, C.W. Liu, C.M. Liao, W.C. Shen, and F.J. Chang. 2011. Arsenite-oxidizing and arsenate-reducing bacteria associated with arsenic-rich groundwater in Taiwan. Journal of Contaminant Hydrology 123:20-29. |
03. |
Wang, L.I., Y.S. Lin, K.H. Liu, A.Y. Jong, and W.C. Shen*. 2011. Cryptococcus neoformans Mediator protein Ssn8 negatively regulates diverse physiological processes and is required for virulence. PLoS One 6(4): e19162. |
04. |
Liu, K.H., Y.L. Yeh, and W.C. Shen*. 2011. Fast preparation of fungal DNA for PCR screening. Journal of Microbiological Methods 85:170-172. |
05. |
Shen, W.C.* and J.Z. Lu. 2011. The MET5 homologue is required for growth, mating, and virulence in Cryptococcus neoformans. Fungal Science 26:23-47. |
06. |
Yeh, Y. L., Y. S. Lin, B. J. Su, and W. C. Shen*. 2009. A screening for suppressor mutants reveals components involved in the blue light-inhibited sexual filamentation in Cryptococcus neoformans. Fungal Genet. Biol. 46:42-54. (SCI) |
07. |
Huang, J. Y., H. T. Hu, and W. C. Shen*. 2009. Phylogenetic study of two truffles, Tuber formosanum and T. furfuraceum, identified from Taiwan. FEMS Microbiology Letters 294:157-171. (SCI) |
08. |
Lin, Y.C., S.L. Wang, W.C. Shen, P.M. Huang, P.N. Chiang, J.C. Liu, C.C. Chen, and Y.M. Tzou. 2009. Photo-enhancement of Cr(VI) reduction by fungal biomassof Neurospora crassa. Applied Catalysis B: Environmental 92:294-300. |
09. |
Hu, H.T., J.Y. Huang, W.C. Shen, and C.L. Lin. 2007. Effects of different temperature on the mycorrhiza formation and growth of seedlings of two truffle species synthesis with Cyclobalanopsis glauca (Qerst.) seedlings. Journal of Experimental Forest National Taiwan University 21:65-77. |
10. |
Lu, Y. K., K. H. Sun, and W. C. Shen*. 2005. Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in Cryptococcus neoformans. Molecular Microbiology 56:480-491. |
11. |
Schroers, H.-J., M. M. Geldenhuis, M. J. Wingfield, M. H. Schoeman, Y.-F. Yen, W.-C. Shen, and B. D. Wingfield. 2005. Classification of the guava wilt fungus Myxosporium psidii, the palm pathogen Gliocladium vermoesenii and the persimmon wilt fungus Acremonium diospyri in Nalanthamala. Mycologia 97: 375-395. |
12. |
Hsueh, Y. P., and W. C. Shen*. 2005. A homolog of Ste6, the a-factor transporter in Saccharomyces cerevisiae, is required for mating but not for monokaryotic fruiting in Cryptococcus neoformans. Eukaryotic cell 4:147-155. |
13. |
Shen, W. C., R. C. Davidson, G. M. Cox, and J. Heitman. 2002. Pheromones stimulate mating and differentiation via paracrine and autocrine signaling in Cryptococcus neoformans. Eukaryotic cell 1:366-377. |
14. |
Lengeler, K. B., R. C. Davidson, C. D’soura, Harashima T., W.-C. Shen, P. Wang, X. Pan, M. Waugh, and J. Heitman. 2000. Signal transduction cascades regulating fungal development and virulence. Microbiology and Molecular Biology Reviews 64: 746-785. (Contributed equally) |
15. |
Shen, W. C., P. Bobrowicz, and D. J. Ebbole. 1999. Isolation of pheromone precursor genes of Magnaporthe grisea. Fungal Genetics and Biology 27: 253-263. |
16. |
Shen, W.C., J. Wieser, T. Adams, and D.J. Ebbole. 1998. The Neurospora rca-1 ?? gene complements an Aspergillus flbD sporulation mutant but has no identifiable role in Neurospora sporulation. Genetics 148:1031-1041. |
17. |
Shen, W. C., and D. J. Ebbole. 1997. Cross-pathway and pathway-specific control of amino acid biosynthesis in Magnaporthe grisea. Fungal Genetics and Biology 21: 40-49. |
18. |
Shen, W. C., and C. P. Lin. 1994. Application of immunofluorescent staining and tissue-blotting techniques for the detection of a mycoplasmalike organism associated with sweet potato witches' broom. Plant Pathol. Bull. 3(2): 79-83. |
19. |
Shen, W. C., and C. P. Lin. 1993. Production of monoclonal antibodies against a mycoplasmalike organism associated with sweet potato witches' broom. Phytopathology 83: 671-675. |
20. |
Lin, C. P., W. C. Shen, H. C. Ko, F. L. Chang, Y. L. Yu, M. F. Chen, and F. Y. Wu. 1993. Application of monoclonal antibodies and cloned DNA probes for detection and differentiation of phytopathogenic mycoplasmalike organism. Plant Pathol. Bull. 2(3): 161-168. |
21. |
Chao, Y. C., H. A. Wood, C. Y. Chang, H. J. Lee, W. C. Shen, and H. T. Lee. 1992. Differential Expression of Hz-1 baculovirus genes during productive and persistent viral infection. J. Virol. 66: 1442-1448. |
| 研討會論文 | |
01. |
Huang, Y.K., C.J. Lin, K.C. Wang, C.J. Chiu, and W. C. Shen. The fate of a living fossil plant after climate change. International Symposium on Climate Change Impact to Plant Health and Quarantine. November 9, 2011. National Chung Hsing University, Taichung, Taiwan. |
02. |
Chang, H.X. and W. C. Shen. MoSRB11, a C-type Cyclin gene, affects DHN-melanin synthesis and pathogenicity in rice blast fungus Magnaporthe oryzae. The 9th International Mycological Congress. August 1-6, 2010. Edinburgh, England. |
03. |
Wang, L. I. and W. C. Shen. Ssn8, a Saccharomyces cerevisiae Mediator homologue, negatively regulates sexual development, invasive growth, and the production of melanin and capsule in Cryptococcus neoformans. XXV Fungal Genetics Conference. March 17-22, 2009. Pacific Grove, CA, USA. |
04. |
Liu, K. H. and W. C. Shen. Cryptococcus neoformans Cdk-related kinase Crk1 plays a negative role in mating differentiation process. XXV Fungal Genetics Conference. March 17-22, 2009. Pacific Grove, CA, USA. |
05. |
Wang, L. I., Y. S. Lin, and W. C. Shen. Ssn8, a Saccharomyces cerevisiae Mediator homologue, regulates diverse physiological processes in Cryptococcus neoformans. 7 th International Conference on Cryptococcus & Cryptococcosis. September 11-14, 2008. Nagasaki, Japan. |
06. |
Yeh, Y. L. and W. C. Shen. Characterization of Cryptococcus neoformans BUD16 homologue. 7 th International Conference on Cryptococcus & Cryptococcosis. September 11-14, 2008. Nagasaki, Japan. |
07. |
Liu, K. H. and W. C. Shen. Identification and characterization of the CRK1 gene in Cryptococcus neoformans. 7 th International Conference on Cryptococcus & Cryptococcosis. September 11-14, 2008. Nagasaki, Japan. |
08. |
Lu, J. Z. and W. C. Shen. Characterization of the MET5 homologuein Cryptococcus neoformans. 7 th International Conference on Cryptococcus & Cryptococcosis. September 11-14, 2008. Nagasaki, Japan. |
09. |
Lin, Y. S. and W. C. Shen. Classic sexual reproduction and monokaryotic fruiting are differentially regulated by the mediator protein Ssn8 in Cryptococcus neofomans. XXIV Fungal Genetics Conference, March 20-25, 2007. Asilomar, California。 |
10. |
Liu, K. H. and W. C. Shen. G-protein alpha subunit Gpa3 regulates sexual differentiation in Cryptococcus neofomans. XXIV Fungal Genetics Conference, March 20-25, 2007. Asilomar, California。 |
11. |
Yeh, Y. L., Y. S. Lin, B. J. Su, and W. C. Shen. Cwc1 and Cwc2 are central regulators of blue light photoresponses in Cryptococcus neoformans. XXIV Fungal Genetics Conference, March 20-25, 2007. Asilomar, California。 |
12. |
Su, B. J., Y. S. Lin, Y. L. Yeh, and W. C. Shen. Dissection of the molecular mechanisms regulating the blue light photoresponses in Cryptococcus neoformans. 2006 International Molecular Mycology Conference in Taiwan. May 24-25, 2006. National Taiwan University, Taipei。 |
13. |
Lu, Y. K., K. H. Sun, and W. C. Shen. Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in C. neoformans. 6 th International Conference on Cryptococcus & Cryptococcosis. June 24-28, 2005. Boston, MA, USA. |
14. |
Lu, Y. K., K. H. Sun, and W. C. Shen. Blue light negatively regulates the sexual filamentation via the Cwc1 and Cwc2 proteins in C. neoformans. XXIII Fungal Genetics Conference, March 15-20, 2005. Pacific Grove, CA, USA. |
15. |
Hsueh, Y. P. and W. C. Shen. A homologue of Ste6p, the a-factor transporter in Saccharomyces cerevisiae, functions bilaterally in Cryptococcus neoformans. XXII Fungal Genetics Conference, March 18-23, 2003. |
16. |
Shen, W. C., P. Bobrowicz, and D. J. Ebbole. 1999. Magnaporthe grisea mating pheromone precursor genes. Twentieth Fungal Genetics Conference, March 23-28, 1999. |
17. |
Bobrowicz, P., R. Lowe, A. Miller, W. C. Shen, P. Kazmierczak, L. B. Shrode, ????? D. J. Ebbole, D. Bell-Pedersen, N. K. Van Alfen. Neurospora mating pheromone precursor genes. Twentieth Fungal Genetics Conference, March 23-28, 1999. |
18. |
Ebbole, D. J., D. Bell-Pedersen, N. Van Alfen, P. Bobrowicz, W. C. Shen, L. A. Shrode, P. McCabe, and P. Kazmierczak. The mating pheromones of Neurospora crassa. Neurospora 1998 Conference, June 18-21, 1998. |
19. |
Shen, W. C., J. Wieser, T. Adams, and D. J. Ebbole. Characterization of a Neurospora crassa gene with sequence and functional homology to Aspergillus nidulans flbD. Ninteenth Fungal Genetics Conference, March 18-23, 1997. |
20. |
Shen, W. C., and D. J. Ebbole. Regulation of genes for amino acids biosynthesis in Magnaporthe grisea. Eighteenth Fungal Genetics Conference, March 21-26, 1995. |
| Oral Presentation | |
01. |
The fate of a living fossil plant after climate change. International Symposium on Climate Change Impact to Plant Health and Quarantine. November 9, 2011. National Chung Hsing University, Taichung, Taiwan. |
02. |
A conserved Mediator homologue regulates physiology and differentiation in fungi. Fuzhou International Symposium of Plant Pathology: Population Genetics and Evolutionary Biology of Plant Pathogens. June 4-7, 2011. Fujian Agriculture and Forestry University, Fuzhou, China. |
03. |
Blue light-mediated sexual filamentation in the human pathogenic fungus Cryptococcus neoformans. May 14, 2010. Sunchon National University, Sunchon, Korea. |
04. |
G-protein alpha subunit Gpa3 regulates sexual differentiation in Cryptococcus neofomans. XXIV Fungal Genetics Conference, March 20-25, 2007. Asilomar, California. |
05. |
Blue light signlaing in Cryptococcus neofomans. 2006 International Molecular Mycology Conference in Taiwan. May 24-25, 2006. National Taiwan University, Taipei. |
06. |
Pheromone response and G protein signaling in Cryptococcus neofomans. October 15, 2003. 2003 Symposium of Medical Mycology. Taipei. |
07. |
Pheromone response and G protein signaling in Cryptococcus neofomans. August 1, 2003. Symposium of Microbial Diversity and Uitilization. Taipei. |
08. |
Genomic study on Ganoderma lucidum. International Symposium on Ganoderma Research, Oct. 21-23, 2002, Shanghai, China. |
09. |
Pheromones control mating and differentiation in Cryptococcus neoformans.Department of Plant Pathology, National Chung Hsing University. May 9, 2002.??? Taichung, Taiwan. |
10. |
Pheromones control mating and differentiation in Cryptococcus neoformans. Department of Entomology, National Taiwan University. October 16, 2001. Taipei, Taiwan. |
11. |
Regulation of development and virulence in human pathogenic fungus, Cryptococcus neoformans. Department of Plant Pathology, National Taiwan University. October 19, 2001. Taipei, Taiwan. |
12. |
Roles of pheromones and light in regulating development in Cryptococcus neoformans. Gordon Research Conference on Cellular and Molecular Mycology. June 18-23, 2000. Holderness school, Plymouth, NH, USA. |
| 專書及專書論文 | |
01. |
Shen, W. C., ``Cloning and characterization of a pheromone precursor gene of Magnaporthe grisea. Ph D Dissertation.``, Texas A&M University., 86 -0 , 01, 1999 |
02. |
Shen, W. C., ``Research and potential application of sexual development in plant pathogenic fungi.``, Monograph of the application of biotechnology in agriculture, 1570 -179 , 01, 2001 |