細胞生物學研究室
 |
專長： |
細胞生物學 |
實驗室： |
一號館 315 / 317 室 | |
電話： |
02-33664998 (Office)、02-33664602 (Lab) | |
傳真： |
02-23636490 | |
E-mail： |
shentl@ntu.edu.tw | |
Website： |
https://shentllab.wordpress.com/ | |
| 細胞面對瞬息萬變的內外在環境刺激必須透過訊息傳遞的過程快速且精準的接收和反應。訊息傳遞的過程是一連串訊息分子，如 protein kinases, adaptor proteins, phospholipids, Ca2+等，有層次、次序及方向性交互作用的結果。因此，改變細胞內訊息傳遞途徑中的任何成員，將會影響到細胞的反應；進而造成生物體生理或病理的變化。 |
| Focal adhesion kinase, 簡稱 FAK 或 p125FAK，是一個細胞內 tyrosine 的磷酸脢，廣泛的存在原核生物中。早期的研究發現，FAK 在 integrin signaling 的訊息傳遞上扮演非常重要的角色；參與 integrin (一種可與細胞外基質結合的細胞表面上雙複合接受體) 的訊息傳遞反應並調控 integrin 相關的細胞功能，例如細胞生長、細胞移動、細胞附著等。因此，許多的證據也顯示，FAK 的活性主要可以受到 integrin 來調控。 |
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| 在嘗試探討是否 integrin 可以直接的與 FAK 進行交互作而對 FAK 刺激其活性，一直都存在相當的爭議。原因是 FAK 的 carboxyl terminal 區域具有一個 focal targeting sequence (簡稱FAT sequence)，負責將 FAK 蛋白專一性的分布到 focal adhesion complex (或稱 focal contacts; 為在細胞表面聚集活化的 integrin 分子其細胞內尾端所形成的聚合體) 當細胞附著時。然而，此一 FAT sequence 並不會與 integrin 的細胞內尾部直接結合，而是透過與 talin 和 paxillin (另外的 focal adhesion complex 蛋白分子) 結合，間接的和 integrin 尾部形成聚合。即使如此，許多的研究包括我們近年來的資料顯示，FAK 經由 FAT sequence 分布到 focal adhesion complex 上並不足以完全活化其活性。其他的因子必須共同參與其活化反應。例如：FAK 的第 397 tyrosine (Tyr397， 為一 autophosphorylation site) 氨基酸位置的磷酸化，產生一個可與含有 SH2 domain (Src homology 2 domain) 的訊息傳遞蛋白結合的結合點。因而可將 FAK 所接受的訊息經由 Src、PI3-kinase、Grb7、PLC-γ 等向下傳遞。若將此一 tyrosine (即 Tyr397) 進行點突變成為 phenylalanine，FAK 的活性便會消失，即使此一突變並不影響到 FAK 的 focal adhesion complex 的分布。另外，我們也發現，FAK 的 amino-terminus，有一區域與其他細胞骨架相關蛋白的氨基酸序列有高度的相似性 (homology) 被稱為 four point one and Ezrin / Radxin / Moesin (FERM) domain, 其具有對 FAK 自我活性調控的功能。若將 FAK 的 FERM domain 進行刪除突變，FAK 的活性便會自發性的增加，不論是在細胞附著或是懸浮的狀態之下。基於上述，對於 FAK 活性的調控機制有必要進一步的釐清。同時，相對於 FAK 的 carboxyl terminus，其 amino terminus 顯少被研究其參與活性調控及細胞功能上的角色。因此，本實驗室將對 FAK 的 amino terminus 在 FAK 本身的活性及功能做進一步的探討；並測試與不同的 integrin 結合及交互作用的能力與角色。 |
| 除此之外，我們也將利用 FAK 細胞或組織專一性的基因剔除鼠探討其在生物體內發育、 生理、及病理的角色。藉此，我們希望可建立 FAK 及其所參與的訊息傳導相關聯的動物模型。提供相關疾病未來治療策略的研究和應用。 |
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| 本實驗室對細胞訊息傳遞路徑的探討也涵蓋近年來在分子植物病理學上相當新穎和重要的基因靜默的現象。對於外來病原的入侵植物寄主，一種內生性的抗病反應可造成寄主植物抵抗病原的成功感染。所利用的機制是受到初步入侵的寄主細胞內可降解及產生病原基因體 (包括 DNA 和 RNA)之衍生物，大小約為 21-25 核苷酸長度的單股 RNA 片段 (又稱 short interference RNAs; 簡稱 siRNAs)。之後，以此 siRNA 對病原基因體有專一性互補的特性，對病原基因體配對形成雙股RNA並進一步在細胞內分解。此一反應也因此可擴大為一連鎖反應，造成系統性抗病。然而，目前我們對於植物基因靜默的生化及分子機轉仍然所之有限。 |
| 植物病原病毒為能達成其成功的侵染寄主植物，相對的也演化發展出對抗基因靜默的機制。某些植物病毒可利用其基因體所轉譯的蛋白分子 (suppressor) 干擾植物內生的基因靜默訊息傳遞路徑。因此，自然演化出的抑制作用，使我們可以利用這些拮抗蛋白分子探索植物內基因靜默的分子機制。同時也可以提供在分子植物病理學上新的致病機轉。 |
| ◆ 細胞訊息傳遞 |
| ◆ 癌症細胞生物學 |
| ◆ 基因剔除 / 轉殖鼠 |
| ◆ 基因靜默分子機制 |
| 2003 美國康乃爾大學 分子醫學系博士 |
| 1994 國立臺灣大學 植物病理學研究所碩士 |
| 1991 國立臺灣大學 植物病蟲害學系學士 |
| 2011/08 迄今 國立臺灣大學植物病理與微生物學系 副教授 |
| 2004/08-2011/08 國立臺灣大學植物病理與微生物學系 助理教授 |
| 2003/07-2004/10 美國心臟協會 博士後研究員 |
| 2003/01-2003/06 美國康乃爾大學 博士後研究 |
| 1996/07-1997/07 國立臺灣大學分子醫學研究所研究助理 |
| 1991/07-1992/07 國立臺灣大學植物病蟲害學系研究助理 |
| ◆ 細胞生物學特論 |
| ◆ 分子生物與細胞學 (Molecular and Cell Biology; 與日本京都大學合開 遠距教學) |
| ◆ 科學方法與寫作 (合開) |
| ◆ 書報討論 上 / 下 |
| ◆ 應用微生物 (合開) |
| ◆ 生物分子交互作用之網絡 (Cellular Network of Biological Molecules 遠距教學) |
| ◆ 植物病原交互作用分子機制 (合開) |
| ◆ 分子生物學 (合開) Chp9, Chp10-11, Chp12 |
| ◆ 植物病毒學實驗 (合開) |
| ◆ 幹細胞生長與分化技術 (合開) |
| ◆ 生物技術核心實驗 (合開) |
| 期刊論文 | |
01. |
DongCho Han, Tang-Long Shen , and Jun-Lin Guan (2000) Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration. J Biol. Chem. 275 (37): 28911-28917 |
02. |
Tang-Long Shen and Jun-Lin Guan (2001) Differential regulation of cell migration and cell cycle progression by FAK complexes with Src, PI3K, Grb7 and Grb2 in focal contacts. FEBS Lett. 499 (1-2): 176-81 |
03. |
DongCho Han, Tang-Long Shen , and Jun-Lin Guan (2001) The Grb7 family proteins: structure, interactions with other signaling molecules and potential cellular functions. Oncogene. 20 (44): 6315-21 |
04. |
Silvia M. Goicoechea, Yizeng Tu, Yun Hua, Ka Chen, Tang-Long Shen , Jun-Lin Guan, and Chuanyue Wu. (2002) Nck-2 interacts with focal adhesion kinase and modulates cell motility. Int. J Biochem. & Cell Biol.34: 791-805 |
05. |
Tang-Long Shen , DongCho Han, and Jun-Lin Guan. (2002) The association of Grb7 with phosphoinositides regulates cell migration. J Biol Chem. 277 (32):29069-77 |
06. |
DongCho Han*, Tang-Long Shen* , Hui Miao, Bingcheng Wang, and Jun-Lin Guan. (2002) EphBI associates with Grb7 and regulates cell migration. J. Biol. Chem. 277 (47): 45655-45661. (* equal contribution) |
07. |
Lee Ann Cooper*, Tang-Long Shen* and Jun-Lin Guan. (2003) Regulation of Focal Adhesion Kinase by its Amino-Terminal Domain through an Autoinhibitory Interaction. Mol. Cell. Biol. 23(22):8030-8041. (* equal contribution) |
08. |
Tang-Long Shen and Jun-Lin Guan. (2004) Grb7 in intracellular signaling and its role in cell regulation. Frontiers in Bioscience 9, 192-200 |
09. |
Peng, X., Ueda, H., Zhou, H., Stokol, T., Shen, T.-L ., Alcaraz, A., Nagy, T., Vassalli, J.-D., and Guan, J.-L. (2004). Overexpression of focal adhesion kinase in vascular endothelial cells promotes angiogenesis in transgenic mice. Cardiovascular Research 64 , 421-430 |
10. |
Weiquan Li, Jeeyong Lee, Haris G Vikis, Seung-Hee Lee, Guofa Liu, Jennifer Aurandt, Tang-Long Shen , Eric R Fearon, Jun-Lin Guan, Min Han, Yi Rao, Kyonsoo Hong & Kun-Liang Guan (2004) Activation of FAK and Src are receptor-proximal events required for netrin signaling . Nature Neuroscience 7, 1213 - 1221 |
11. |
Hui Miao, Klaus Strebhardt, Elena B. Pasquale, Tang-Long Shen , Jun-Lin Guan, and Bingcheng Wang (2005) Inhibition of integrin-mediated cell adhesion but not directional cell migration requires catalytic activity of EphB3 receptor tyrosine kinase: Role of Rho family small GTPases. J. Biol. Chem. 280(2):923-32 |
12. |
Tang-Long Shen , Ann Y.-J. Park, Ana Alcaraz, Xu Peng, Ihnkyung Jang, Pandelakis Koni, Richard A. Flavell, Hua Gu and Jun-Lin Guan (2005) Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis. J. Cell Biol. 169(6):941-52 |
13. |
Xu Peng, Marc S. Kraus, Huijun Wei, Tang-Long Shen, Romain Pariaut, Ana Alcaraz, Guangju Ji, Lihong Cheng, Qinglin Yang, Michael I. Kotlikoff, Ju Chen, Kenneth Chien, Hua Gu and Jun-Lin Guan (2006) Inactivation of focal adhesion kinase in cardiomyocytes promotes cardiac eccentric hypertrophy and fibrosis in mice. J. Clinical Investigation 116(1):217-27 |
14. |
Huang MC*, Chen HY, Huang HC, Huang J, Shen TL, Lin NY, Liang JT, Ho CC, Cho IM, Hsu SM. (2006) Mucin-type core 2 β-1,6-N-acetylglucosaminyltransferase is downregulated in colorectal cancer and its re-expression causes growth inhibition of colon cancer cells. Oncogene 25(23):3267-76 (*corresponding author) |
15. |
Hsiu-Chin Huang, Hsiao-Yu Chen, Chia-Yang Chen, Tang-Long Shen, John Huang, Neng-Yu Lin, Shao-Yin Sum, Mei-Ieng Che, Min-Chuan Huang (2007) Ammonium hydroxide extracts from black tea inhibit growth, migration, and invasion of colon cancer cells. Journal of Food Biochemistry (accepted) |
16. |
John Huang, Jin-Tung Liang, Hsiu-Chin Huang, Tang-Long Shen, Hsiao-Yu Chen, Neng-Yu Lin, Mei-Ieng Che, Wei-Chou Lin, Min-Chuan Huang (2007) β1,4-N-acetylgalactosaminyltransferase III enhances malignant phenotypes of colon cancer cells. Molecular Cancer Research 5(6):543-52 |
17. |
Tamas Nagy, Huijun Wei, Tang-Long Shen, Xu Peng, Chun-Chi Liang, Boyi Gan, and Jun-Lin Guan (2007)Mammary epithelial-specific deletion of the focal adhesion kinase gene leads to severe lobulo-alveolar hypoplasia and secretory immaturity of the murine mammary gland. J. Biol. Chem. 2007 Aug 23; [Epub ahead of print] |
18. |
SM Weis, S-T Lim, KM Lutu-Fuga, LA Barnes, X.L. Chen, J.R. Göthert, T-L Shen, J-L Guan, DD Schlaepfer, DA Cheresh. 2008. Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK. J. Cell Biol. 181(1):43-50. 10.257. |
19. |
Ann Y.J. Park, Tang-Long Shen, Shu Chien and Jun-Lin Guan. 2009. Role of focal adhesion kinase S732 phosphorylation in centrosome function during mitosis. J. Biol. Chem. 284(14):9418-25. |
20. |
Pei-Yu Chu, Ling-Ya Huang, Hsiao-Hsin Chen, Chun-Hua Hsu, Chun-Chi Liang, Jun-Lin Guan, Ting-Hsuan Hung, Tang-Long Shen*. 2009. Tyrosine phosphorylation of Grb7 by FAK in the regulation of cell migration, proliferation and tumorigenesis. J. Biol. Chem. 284(30):20215-26. |
21. |
Bor-Sheng Ko, Tzu-Ching Chang, Chien-Hung Chen, Chia-Chia Liu, Shu-Man Liang, En-Wei Hsing, Cheng-Chin Kuo, Chiun Hsu, Ying-Chun Shen, Tang-Long Shen, Song-Kun Shyue, Vita M. Golubovskaya, Chung-Che Chang and Jun-Yang Liou (2009) Bortezomib suppresses focal adhesion kinase expression via interrupting nuclear factor-kappa B Life Science 86(5-6):199-206 |
22. |
Y. H. Yu, S. C. Wu, W. T. K. Cheng, H. J. Mersmann, T. L. Shen* and S. T. Ding* (2010)The function of porcine PPARγ and dietary fish oil effect on the expression of lipid and glucose metabolism related genes (* co-corresponding author; accepted) |
23. |
Chen HH, Chen CW, Chang YY, Shen TL, Hsu CH.(2010) Preliminary crystallographic characterization of the Grb2 SH2 domain in complex with a FAK-derived phosphotyrosyl peptide Acta Crystallogr Sect F Struct Biol Cryst Commun.66(Pt 2):195-7. |
24. |
Chun-Jiun Yang, Chi-Fon Chang*, Lin-Ya Huang, Yu-Yung Chang, Tang-Long Shen, and Chun-Hua Hsu*. (2010) Resonance assignments of human C35 (C17orf37) protein, a novel tumor biomarker. Biomol. NMR Assign.4(2):191-3 |
25. |
Jia-Rong Fan, Ting-Hsiang Huang, Chen-Yu Wen, Tang-Long Shen* and Tsai-Kun Li* (2010) Sodium salicylate acts through direct inhibition of phosphoinositide 3-kinase-like kinases to modulate topoisomerase-mediated DNA damage responses. European Journal of Pharmacology 638(1-3):13-20 (*correspondence; accepted) |
26. |
Chung-Yao Yang, Lin-Ya Huang, Tang-Long Shen*, J. Andrew Yeh* (2010) Cell adhesion, morphology and biochemistry on nano-topographic oxidized silicon surfaces e Cells and Materials Journal 20:415-430(* co-corresponding authors) |
27. |
I-Rue Lai, Pei-Yu Chu, Hsiao-Sheng Lin, Jun-Yang Liou, Yee-Jee Jan, Jen-Chieh Lee, Tang-Long Shen* (2010) Autophosphorylation of Tyr-397 of focal adhesion kinase in gastric carcinoma and its clinical significance. American Journal of Pathology 177(4):1629-37 (This article is highlighted by Nature Reviews Gastroenterology and Hepatology 7, 592) |
28. |
Pei-Yu Chu, Tsia-Kun Li, Shih-Torng Ding, I-Rue Lai, Tang-Long Shen* (2010) EGF-induced Grb7 activation promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells. Journal Biological Chemistry 285(38):29279-85 |
29. |
Bor-Sheng Ko, Tzu-Ching Chang, Chiun Hsu, Chia-Chia Liu, Chien-Hung Chen, ????????????Yao-Chang Chen, Tang-Long Shen, Shyh-Chang Chen, JohnWang, Kenneth K.??? ????????????Wu, Yee-Jee Jan, Jun-Yang Liou (2010) 14-3-3ε protein overexpression and? ????????????liver cancer metastasis and survival. Histopathology 58(5):705-11 |
30. |
Liu TA, Jan YJ, Ko BS, Chen SC, Liang SM, Hung YL, Hsu C, Shen TL, Lee YM, Chen PF, Wang J, Shyue SK, Liou JY. (2011) Increased expression of 14-3-3β promotes tumor progression and predicts extrahepatic metastasis and worse survival in hepatocellular carcinoma. American Journal of Pathology 179(6):2698-708. |
31. |
Lih Ru Liu, Shau Ping Lin, Chih-chien Chen, Yu Jen Chen , Chen Chen Tai, ShihChung Chang, Rong Huay Juang , Yi Wen Tseng, Bing Hsien Liu, Harry J. Mersamm, Tang Long Shen*, and Shih Torng Ding* (2011) Serum amyloid A induces lipolysis by down-regulating perilipin through ERK1/2 and PKA signaling pathways.Obesity 19(12):2301-9. (co-corresponding author) |
32. |
Li-Ya Wang, Shih-Shun Lin, Ting-Hsuan Hung, Tsai-Kun Li, Nai-Chun, Lin, Tang-Long Shen* (2012) Multiple domains of the Tobacco mosaic virus p126 protein can independently suppress local and systemic RNA silencing. Microbe-Plant Molecular Interactions 25(5):648-57. |
33. |
Yang CY, Liao TC, Shuai HH, Shen TL*, Yeh JA, Cheng CM (2012) Micropatterning of mammalian cells on inorganic-based nanosponges. Biomaterials 33(20):4988-97 (co-corresponding author) |
34. |
Chang TC, Liu CC, Hsing EW, Liang SM, Chi YH, Sung LY, Lin SP, Shen TL, Ko BS, Yen BL, Yet SF, Wu KK, Liou JY. 14-3-3σ Regulates β-Catenin-Mediated Mouse Embryonic Stem Cell Proliferation by Sequestering GSK-3β. PLoS ONE. 2012;7(6):e40193. |
35. |
Lin CE, Chen SU, Lin CC, Chang CH, Lin YC, Tai YL, Shen TL, Lee H (2012) Lysophosphatidic Acid Enhances Vascular Endothelial Growth Factor-C Expression in Human Prostate Cancer PC-3 Cells. PLoS One. 2012;7(7):e41096. |
36. |
Yang Y, Chou HY, Shen TL, Chang WJ, Tai PH, Li TK (2013) Topoisomerase II-mediated DNA cleavage and mutagenesis activated by nitric oxide underlie the inflammation-associated tumorigenesis. Antioxid Redox Signal. 18(10):1129-40 |
37. |
Chun-Hua Hsu, Tang-Long Shen, Chi-Fon Chang, Yu-Yung Chang, Lin-Ya Huang (2012) Solution Structure of the Oncogenic MIEN1 Protein Reveals a Thioredoxin-Like Fold with a Redox-Active Motif. PLoS ONE 7(12): e52292 |
38. |
Wen-Ling Yao, Bor-Sheng Ko,Tzu-An Liu, Shu-Man Liang, Chia-Chia Liu, Yi-Jhu Lu, Shean-Shong Tzean, Tang-Long Shen*, and Jun-Yang Liou (2014) Cordycepin suppresses integrin/FAK signaling and EMT in hepatocellular carcinoma. Anti-Cancer Agents in Medicinal Chemistry;14(1):29-34. (Co-corresponding authors) |
39. |
Schmidt TT, Tauseef M, Yue L, Bonini MG, Gothert J, Shen TL, Guan JL, Predescu S, Sadikot R, Mehta D (2013) Conditional deletion of FAK in mice endothelium disrupts lung vascular integrity due to destabilization of RhoA and Rac1 activities. American Journal of Physiology - Lung Cellular and Molecular Physiology 305(4):L291-300. |
40. |
Bor-Sheng Ko, Yi-Jhu Lu, Wen-Ling Yao, Tzu-An Liu, Shean-Shong Tzean, Tang-Long Shen, Jun-Yang Liou (2013) Cordycepin regulates GSK3b/b-catenin signaling in human leukemia cells. Plos ONE 8(9):e76320 |
41. |
Hsieh MY, Fan JR, Chang HW, Chen HC, Shen TL, Teng SC, Yeh YH, Li TK (2014) DNA Topoisomerase III Alpha Regulates p53-Mediated Tumor Suppression Clin Cancer Res. 20(6):1489-501 |
42. |
Shang-Min Chou, Wan-Jung Lai, Tzu-Wen Hong, Jui-Ya Lai, Sheng-Hong Tsai, Yen-Hsun Chen, Sz -Hsien Yu, Cheng-Hsiang Kao, Richard Chu, Shih-Torng Ding, Tsai-Kun Li and Tang-Long Shen* (2014) Synergistic property of Cordycepin incultivated Cordyceps militaris-mediated apoptosis in human leukemia cells Phytomedicine 21 (12): 1516–1524 |
43. |
Chun-Yi Lin, Meng-Ling Wu, Tang-Long Shen, Hsin-Hung Yeh and Ting-Hsuan Hung (2015) Development of molecular detection system and field investigation for two citrus viroids in Taiwan. Virology Journal 12(1):11. |
44. |
Yu-Lin Tai, Lih-Charng Chen, Tang-Long Shen* (2015) Emerging roles of focal adhesion kinase in cancer. BioMed Research International: 2015:690690. Epub 2015 Mar 31 |
45. |
Yu-Ling Tai, Pei-Yu Chu, I-Rui Lai, Hui-Yuan Tseng, Jun-Yang Liou, Jun-Lin Guan, Tang-Long Shen* (2015) An EGFR/Src-dependent b4 Integrin/FAK complex contributes to the malignancy of breast cancer. Scientific Reports 5, 16408; doi: 10.1038/srep16408 |
46. |
Yen-Wen Wang, Tzu-Wen Hong, Yu-Ling Tai, Ying-Jing Wang, Sheng-Hong Tsai, Pham Thi Kim Lien, Tzu-Ho Chou, Jui-Ya Lai, Richard Chu, Shih-Torng Ding, Kenji Irie, Tsai-Kun Li, Shean-Shong Tzean and Tang-Long Shen* (2015) Evaluation of an epitypified Ophiocordyceps formosana (Cordyceps s.l.) for its pharmacological potential. Evidence-based complementary and alternative medicine Volume 2015, Article ID 189891 |
47. |
Shang-Min Chou, Wan-Jung Lai, Tzuwen Hong, Sheng-Hong Tsai, Yen-Hsun Chen, Cheng-Hsiang Kao, Richard Chu, Tang-Long Shen* and Tsai-Kun Li* (2015) Involvement of p38 MAPK in the anticancer activity of cultivated Cordyceps militaris. The American Journal of Chinese Medicine 43(5):1043-1057 (co-corresponding author) |
48. |
Bruno Costa-Silva, Nicole M. Aiello, Swarnima Singh, Haiying Zhang, Basant Kumar Thakur, Annette Becker, Ayuko Hoshino, Milica Te?i? Mark, Henrik Molina, Jenny Xiang, Tuo Zhang, Till-Martin Theilen, Guillermo Garcia-Santos, Caitlin Williams, Yonathan Ararso, Yujie Huang, Goncalo Rodrigues, Tang-Long Shen, Knut Jorgen Labori, Inger Marie Bowitz Lothe, Elin H. Kure, Allyson J. Ocean, Jonathan Hernandez, Alexandre Doussot, Saya Ebbesen, Paul Grandgenett, Michael Hollingsworth, Maneesh Jain, Kavita Mallya, Surinder Batra, William R. Jarnagin, Robert E. Schwartz, Irina Matei, Hector Peinado, Ben Stanger, Jacqueline Bromberg, and David Lyden (2015) Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver. Nature Cell Biol. 17(6):816-26. |
49. |
Ayuko Hoshino*, Bruno Costa-Silva*, Tang-Long Shen*, Goncalo Rodrigues, Ayako Hashimoto, Milica Tesic Mark, Henrik Molina, Shinji Kosaka, Angela Di Giannatale, Sophia Ceder, Swarnima Singh, Caitlin Williams, Nadine Soplop, Kunihiro Uryu, Lindsay Pharmer, Tari King, Linda Bojmar, Alexander E. Davies,Yonathan Ararso, Tuo Zhang, Haiying Zhang, Jonathan Hernandez, Joshua M. Weiss, Vanessa D. Dumont-Cole, Kimberly Kramer, Leonard H. Wexlex, Aru Narendran, Gary K. Schwartz. John H. Healey, Per Sandstrom, Knut Jorgen Labori, Elin H. Kure, Kavita Mallya, Surinder K. Batra, Rajesekhar K. Vinagolu, Oystein Fodstad, Volkmar Muller, Klaus Pantel, Andy J. Minn, Mina J. Bissell, Benjamin A. Garcia, Yibin Kang, Vinagolu K. Rajasekhar, Cyrus M. Ghajar, Irina Matei, Hector Peinado, Jacqueline Bromberg, David Lyden (2015) Tumor exosome integrins determine organotropic metastasis. Nature 527(7578):329-35 (*co-first authors) |
50. |
Chun-Yi Lin, Meng-Ling Wu, Tang-Long Shen, Ting-Hsuan Hung (2015) A mutual titer-enhancing relationship and similar localization patterns between Citrus exocortis viroid and Hop stunt viroid co-infecting two citrus cultivara Virology Journal 12(1):142 |
51. |
Han-Lin Liu, Yang-Wei Liu, Tang-Long Shen, Chun-Hua Hsu and Ya-Chun Chang (2015) Characterization and application of a common epitope recognized by a broad-spectrum C4 monoclonal antibody against capsid proteins of plant potyviruses. Applied Microbiology and Biotechnology DOI 10.1007/s00253-015-7116-x |
52. |
Yu-Ling Tai, I-Rue Lai, Yu-Ju Peng, Shih-Torng Ding, Tang-Long Shen* Activation of focal adhesion kinase through an interaction with β4 integrin contributes to colon cancer progression. FEBS letters (under revision) |
53. |
Yu-Ling Tai, Li-Hsuan Tung, Yu-Chi Lin, Pei-Jung Lu, Tang-Long Shen (2015) Pin1 negatively regulated Grb7 protein stability via the ubiquitin-proteosome pathway requires the cis-trans isomerase activity of Pin1. PLoS One (under revision) |
54. |
Daniela Gwiazdowska , Katarzyna Staszak , Dr. Ying-Lien Chen , Tang-Lon Shen (2015) Surface and antimicrobial activity of sulfobetaines (submitted) |
55. |
Pei-Yu Chu, Yu-Ling Tai, Tang-Long Shen* (2015) Transcriptional up-regulation of EphA4 by EGF-Grb7-Stat3 signaling promotes lung cancer progression. (in preparation) |
56. |
Chao-Wei Huang, Tzu-Wen Hong, Ying-Jing Wang, Ju-Chun Pe, Wen-Sung Lai, Shih-Torng Ding, and Tang-Long Shen* (2015) Ophiocordyceps formosana extract improves hyperglycemia and depression in an STZ-induced mouse model (submitted) |
57. |
Tang-Long Shen*, Lin-Ya Huang, Yun-Ting Tsou, Hsin-Jung Wu, Chun-Hua Hsu, Jun-Lin Guan* (2015) Activation of focal adhesion kinase through its FERM domain-mediated interaction with D3-phosphoinositides (in preparation) |
| 研討會論文 | |
01. |
Hui-Yuan Tseng1, Mossaad Abdel-Ghany2, Bendicht Pauli2, Jun-Lin Guan2,3, Tang-Long Shen1, ``Direct Interaction between focal adhesion kinase (FAK) and integrin beta4 in tumorigenesis``, The American Society for Cell Biology 46th annual meeting, 12, 2006 |
02. |
Tang-Long Shen1*, Hui-Yuan Tseng1, Chun-Hua Hsu2, Jun-Lin Guan3, ``Association of focal adhesion kinase with phosphoinositides modulates its activity and cell migration``, NHRI Symposium in Cell Signaling And Developmental Biology, 05, 2007 |
03. |
Li-Ya Wang and Tang-Long Shen, ``Molecular dissection of gene silencing suppression mediated by the TMV-encoded p126 protein``, 第13屆植物與微生物分子交互作用國際會議, 07, 2007 |
04. |
Yu-Ling Tai1, Hui-Yuan Tseng1, Mossaad Abdel-Ghany2, I-Rui Lai1, Bendicht Pauli2, Jun-Lin Guan2,3, Tang-Long Shen1, ``The Physical and Functional Association Between Integrin β4 and Focal Adhesion Kinase in Tumor Metastasis``, AACR-Cytoskeleton Signaling in Cancer, 02, 2008 |