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National Taiwan University  School of Medicine and School of Engineering

Institute of Biomedical Engineering

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Cell and Tissue Engineering Laboratory

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Welcome to the Chao Lab.

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Our research focuses on the interaction between cell/tissues with their physical environment.  Using truly interdisciplinary approaches, we investigate mechanobiology and cell-material interactions with tools in biomechanics, bioMEMS, polymer science and cell biology.  One of our interests is understanding how substrate dimensionality (2D vs 3D), mechanical properties (stiffness and anisotropy), and organization (structure and topography) influence phenotypic expressions of ligament fibroblast and differentiation of mesenchymal stem cell (MSC).  We also apply physical stimulation such as deformational loading and electric fields with custom bioreactors to examine the dynamic interaction of the physical environment with cells.  These understandings can help us better control the cellular microenvironment and optimize designs for tissue engineering.

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Lab News

Positions Open!
Undergraduate and graduate student positions open!  If you are interested in Tissue Engineering, Cell-material Interaction, Mechanical Design, or bioMEMS, please contact Dr. Chao.

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Our work on the mechanism of electric field-induced cell migration, 'Lipid Rafts Sense and Direct Electric Field-induced Migration', has been published on PNAS.  Congratulations to everyone involved!

- July, 2017

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Congratulations to Ms. Wen on presenting her work 'Anisotropic YAP mechanosensing' at a podium session in the SB3C conference in Tucson, AZ!

- June, 2017

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Mr. Lee presented his work on 'Electrospinning with Porogen in Tissue Engineered Constructs' in the 2017 ORS in San Diego, CA, to a great audience!

- March, 2017

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Our collaboration with Columbia University, 'Stem cell delivery in tissue-specific hydrogel enabled meniscal repair in an orthotopic rat model' has been published in Biomaterials.

- April, 2017

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Our collaboration with University of Pennsylvania, 'Crimped nanofibrous biomaterials mimic microstructure and mechanics of native tissue and alter strain transfer to cells' has been accepted for publication at ACS Biomaterials Science & Engineering.

- December, 2016

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All Rights Reserved.  Last Update July 2017