Neuobehavioral function and dysfunction
My primary research interest
pertains to stroke rehabilitation, including comparative efficacy trials
and applied translational research. I and my colleagues have investigated
task-specific rehabilitation (eg,
constraint-induced therapy [CIT], bilateral arm training [BAT], mirror
therapy [MT], and robot-assisted therapy [RAT]) for improving motor control
and functional outcomes in stroke patients. My research has demonstrated
domain-specific outcomes of rehabilitative therapies and task-specificity
of brain plastic changes after interventions (eg,
fMRI changes in response to different treatment
regimens shown in the figure). To explore possible mechanisms of
motor recovery and clarify changes in motor control strategy after neurorehabilitation, I and my colleagues have used
kinematic analysis to identify specific changes in movement control after
stroke rehabilitation in terms of efficiency, smoothness, and preplanning.
Extended research has been geared towards the study of benefits and adverse
effects of specific stroke rehabilitation to project the profile of
dose-effect relations.
