學院

醫學院

系所

職能治療學系

題名

Constraint-induced therapy versus control intervention in patients with stroke: a functional magnetic resonance imaging study

作者

Lin, K-C., Chung, H-Y., Wu, C-Y., Liu, H-L., Hsieh, W-Y., Chen, I-H., Chen, C-L., Chuang, L-L., Liu, J-S. & Wai, Y-Y

期刊名稱

American Journal of Physical Medicine and Rehabilitation(SCI 期刊)

發表日期

2010

著作性質

原著

語文

英文

關鍵字

Cerebrovascular Disease, Rehabilitation, Upper Extremity, Functional Brain Imaging, Plasticity

摘要

ABSTRACT Objective: This study compared the effects of a distributed form of constraint-induced therapy (dCIT) with control intervention (CI) in motor recovery and brain reorganization after stroke. Design: A 2-group randomized controlled trial with pretreatment and posttreatment measures was conducted. Thirteen stroke patients were randomly assigned to the dCIT (n = 5) or the CI group (n = 8). Outcome measures included the Fugl-Meyer Assessment (FMA), the Motor Activity Log (MAL), and functional magnetic resonance imaging (fMRI) examination. The number of activation voxels and laterality index were determined from the fMRI data for the study of brain reorganization. Results: The dCIT group exhibited significantly greater improvements in the FMA and MAL than the CI group. The fMRI data showed that dCIT significantly increased activation in the contralesional hemisphere during movement of the affected and unaffected hand. The CI group showed a decrease in primary sensorimotor cortex activation of the ipsilesional hemisphere during movement of the affected hand. Conclusions: The preliminary findings indicate that brain adaptation may be modulated by specific rehabilitation practices, although generalization of the fMRI findings is limited by sample size. Further research is needed to identify the specific neural correlates of the behavioral gains achieved after rehabilitation therapies.