學院	醫學院
系所	職能治療學系
題名	Effects of robotic priming of bilateral arm training, mirror therapy and impairment-oriented training on sensorimotor and daily functions in patients with chronic stroke: Study protocol of a single-blind, randomized controlled trial.
作者	Lee, Y-C., Li, Y-C., Lin, K-C.*, Yao, G., Chang, Y-J., Lee, Y-Y., Liu, C-T., Hsu, W-L., Wu, Y-H., Chu, H-T., Liu, T-X., Yeh, Y-P., & Chang, C.
期刊名稱	Trials
發表日期	2022
著作性質	原著
語文	英文
關鍵字	Stroke, Upper extremity rehabilitation, Bilateral motor priming, Bilateral arm training, Mirror therapy, Impairment-oriented training, Randomized controlled trial
摘要	Background. Combining robotic therapy (RT) with task-oriented therapy is an emerging strategy to facilitate motor relearning in stroke rehabilitation. This study protocol will compare novel rehabilitation regimens that use bilateral RT as a priming technique to augment two task-oriented therapies: mirror therapy (MT) and bilateral arm training (BAT) with a control intervention: RT combined with impairment-oriented training (IOT). Methods. This single-blind, randomized, comparative efficacy study will involve 96 participants with chronic stroke. Participants will be randomized into bilateral RT+MT, bilateral RT+BAT, and bilateral RT+IOT groups and receive 18 intervention sessions (90 min/d, 3 d/wk for 6 weeks). The outcomes will include the Fugl-Meyer Assessment, Stroke Impact Scale version 3.0, Medical Research Council scale, Revised Nottingham Sensory Assessment, ABILHAND Questionnaire, and accelerometer, and will be assessed at baseline, after treatment, and at the 3-month follow-up. Analysis of covariance and the chi-square automatic interaction detector method will be used to examine the comparative efficacy and predictors of outcome, respectively, after bilateral RT+MT, bilateral RT+BAT, and bilateral RT+IOT. Discussion. The findings are expected to contribute to the research and development of robotic devices, to update the evidence-based protocols in post-acute stroke care programs, and to investigate the use of accelerometers for monitoring activity level in real-life situations, which may in turn promote home-based practice by the patients and their caregivers. Directions for further studies and empirical implications for clinical practice will be further discussed in upper-extremity rehabilitation after stroke.