學院 |
醫學院 |
系所 |
職能治療學系 |
題名 |
Synergistic effects of aerobic exercise and cognitive training
on cognition, physiological markers, daily function, and quality of life in
stroke survivors with cognitive decline: study protocol for a randomized
controlled trial |
作者 |
Yeh, T-T., Wu, C-Y.*, Hsieh,
Y-W., Chang, K-C., Lee, L-C., Hung, J-W., Lin, K-C., Teng, C-H., & Liao, Y-H. |
期刊名稱 |
Trials |
發表日期 |
2017 |
著作性質 |
原著 |
語文 |
英文 |
關鍵字 |
Stroke, Cognitive rehabilitation, Aerobic
exercise, Cognitive training, Sequential training |
摘要 |
Background: Aerobic exercise and cognitive training have been effective in
improving cognitive functions; however, whether the combination of these two
can further enhance cognition and clinical outcomes in stroke survivors with cognitive
decline remains unknown. This study aimed to determine the treatment effects
of a sequential combination of aerobic exercise and cognitive training on
cognitive function and clinical outcomes. Methods/design: Stroke survivors (n = 75) with cognitive decline will be recruited
and randomly assigned to cognitive training, aerobic exercise, and sequential
combination of aerobic exercise and cognitive training groups. All
participants will receive training for 60 minutes per day, 3 days per week
for 12 weeks. The aerobic exercise group will receive stationary bicycle
training, the cognitive training group will receive cognitive-based training,
and the sequential group will first receive 30 minutes of aerobic exercise,
followed by 30 minutes of cognitive training. The outcome measures involve
cognitive functions, physiological biomarkers, daily function and quality of
life, physical functions, and social participation. Participants will be
assessed before and immediately after the interventions, and 6 months after the
interventions. Repeated measures of analysis of variance will be used to evaluate
the changes in outcome measures at the three assessments. Discussion: This trial aims to explore the benefits of innovative intervention
approaches to improve the cognitive function, physiological markers, daily
function, and quality of life in stroke survivors with cognitive decline. The
findings will provide evidence to advance post-stroke cognitive
rehabilitation. Trial
registration: ClinicalTrials.gov, NCT02550990. Registered on 6
September 2015. |