學院 |
醫學院 |
系所 |
職能治療學系 |
題名 |
Effect of action observation therapy and
mirror therapy after stroke on rehabilitation outcomes and neural mechanisms
by MEG: study protocol for a randomized controlled trial |
作者 |
Shih, T-Y., Wu, C-Y., Lin, K-C., Cheng, C-H., Hsieh, Y-W.*, Chen, C-L., Lai,
C-J., & Chen, C-C. |
期刊名稱 |
Trials |
發表日期 |
2017 |
著作性質 |
原著 |
語文 |
英文 |
關鍵字 |
Stroke, Neurorehabilitation, Action observation,
Mirror therapy, Magnetoencephalography |
摘要 |
Background: Loss of upper-extremity motor function is one of the most
debilitating deficits following stroke. Two promising treatment approaches,
action observation therapy (AOT) and mirror therapy (MT), aim to enhance
motor learning and promote neural reorganization in patients through
different afferent inputs and patterns of visual feedback. Both approaches
involve different patterns of motor observation, imitation, and execution but
share some similar neural bases of the mirror neuron system. AOT and MT used
in stroke rehabilitation may confer differential benefits and neural
activities that remain to be determined. This clinical trial aims to
investigate and compare treatment effects and neural activity changes of AOT
and MT with those of the control intervention in patients with subacute
stroke. Methods/design: An estimated total of 90 patients with subacute stroke will be
recruited for this study. All participants will be randomly assigned to
receive AOT, MT, or control intervention for a 3-week training period (15 sessions).
Outcome measurements will be taken at baseline, immediately after treatment,
and at the 3-month followup. For the magnetoencephalography (MEG) study, we
anticipate that we will recruit 12 to 15 patients per group. The primary
outcome will be the Fugl-Meyer Assessment score. Secondary outcomes will
include the modified Rankin Scale, the Box and Block Test, the ABILHAND
questionnaire, the Questionnaire Upon Mental Imagery, the Functional Independence
Measure, activity monitors, the Stroke Impact Scale version 3.0, and MEG
signals. Discussion: This clinical trial will provide scientific evidence of treatment
effects on motor, functional outcomes, and neural activity mechanisms after
AOT and MT in patients with subacute stroke. Further application and use of
AOT and MT may include telerehabilitation or home-based rehabilitation
through web-based or video teaching. Trial
registration: ClinicalTrials.gov, ID: NCT02871700. Registered
on 1 August 2016 |