學院 |
醫學院 |
系所 |
職能治療學系 |
題名 |
A
preliminary investigation of the association of sleep with inflammation and
oxidative stress biomarkers and functional outcomes after stroke
rehabilitation |
作者 |
Yeh, T-T., Hsieh, Y-W., Wu, C-Y., Wang, J-S., Lin, K-C. *, & Chen, C-L. |
期刊名稱 |
Scientific
Reports |
發表日期 |
2017 |
著作性質 |
原著 |
語文 |
英文 |
關鍵字 |
Inflammation; oxidative stress; sleep; stroke;
rehabilitation; clinical assessment |
摘要 |
Objective: This study examined the association of sleep
with inflammation and oxidative stress biomarkers, and with functional
outcomes, after stroke rehabilitation. The rehabilitation effects on
biomarkers and functional outcomes were also evaluated. Design: Twenty subacute stroke survivors received 4 weeks
of upper limb rehabilitation. Baseline inflammatory (i.e., soluble
intercellular adhesion molecule-1, sICAM-1) and oxidative stress biomarkers
(i.e., glutathione peroxidase, GPx and malondialdehyde, MDA) were assessed,
as were sleep outcomes. Results: Positive correlations were observed between baseline level of sICAM-1 and number of awakenings at post-treatment (ρ = 0.51, p < 0.05) as well as between baseline level of MDA and post-performance time of the Wolf Motor Function Test (WMFT-time) (ρ = 0.46, p < 0.05). In addition, MDA levels were significantly decreased, and functional outcomes of the modified Rankin Scale (mRS), functional ability scale of the WMFT, and Stroke Impact Scale (SIS-total, and SIS-physical function) were improved after the rehabilitation. Conclusions: This pilot study emphasizes the relationship
among biomarkers, sleep, and functional outcomes after stroke rehabilitation.
Oxidative stress markers may be useful predictors of functional outcomes in
subacute stroke survivors. |