學院 |
醫學院 |
系所 |
職能治療學系 |
題名 |
The reliability and predictive ability
of a biomarker of oxidative DNA damage
on functional outcomes after stroke rehabilitation |
作者 |
Hsieh, Y-W., Lin, K-C.,
Korivi, M., Lee, T-H., Wu,
C-Y.*,
& Wu, K-Y. |
期刊名稱 |
International Journal of Molecular
Sciences |
發表日期 |
2014 |
著作性質 |
原著 |
語文 |
英文 |
關鍵字 |
oxidative
stress; stroke; rehabilitation; biomarker; clinical evaluation |
摘要 |
We evaluated the reliability of
8-hydroxy-2'-deoxyguanosine (8-OHdG), and determined its ability to predict
functional outcomes in stroke survivors. The rehabilitation effect on 8-OHdG
and functional outcomes were also assessed. Sixty-one stroke patients
received a 4-week rehabilitation. Urinary 8-OHdG levels were determined by
liquid chromatography–tandem mass spectrometry. The test-retest reliability
of 8-OHdG was good (interclass correlation coefficient = 0.76). Upper-limb
motor function and muscle power determined by the Fugl-Meyer Assessment (FMA)
and Medical Research Council (MRC) scales before rehabilitation showed
significant negative correlation with 8-OHdG (r = −0.38, r =
−0.30; p < 0.05). After rehabilitation, we found a fair and
significant correlation between 8-OHdG and FMA (r = −0.34) and 8-OHdG
and pain (r = 0.26, p < 0.05). Baseline 8-OHdG was
significantly correlated with post-treatment FMA, MRC, and pain scores (r =
−0.34, −0.31, and 0.25; p < 0.05), indicating its ability to
predict functional outcomes. 8-OHdG levels were significantly decreased, and
functional outcomes were improved after rehabilitation. The exploratory study
findings conclude that 8-OHdG is a reliable and promising biomarker of
oxidative stress and could be a valid predictor of functional outcomes
in patients. Monitoring of behavioral indicators along with biomarkers may
have crucial benefits in translational stroke research. |