研究室: 臺大生化館R310
電 話:

886-2-3366-5960(生命科學院 院長室)
886-2-2312-3456 #88607(醫學院 毒理學研究所)

傳 真: 886-2-2364-0353(生命科學院辦公室)
886-2-2363-5038(生化科學研究所)
地 址:

10617台北市大安區羅斯福路四段1號 國立臺灣大學生命科學館 1216室
10617台北市大安區羅斯福路四段1號 國立臺灣大學生化科學研究所

電子信箱: kuominliang@ntu.edu.tw

1985 -1989 國立臺灣大學生化學研究所 博士
1984 -1985 國立臺灣大學生化學研究所 碩士
1980 -1984 私立輔仁大學食品科學系   學士

2012/08~ 國立臺灣大學生命科學院 院長
國立臺灣大學生命科學院生化科學研究所 教授
國立臺灣大學漁業生物試驗所 所長
國立臺灣大學醫學院 毒理學研究所 合聘教授
2009/08 -2012/07 行政院國家科學委員會 生物科學發展處 處長
2007/08 -2009/07 國立臺灣大學醫學院 副院長兼研發室主任
1999/08 -2012/07 國立臺灣大學醫學院 毒理學研究所 教授
2006/07 -2007/07 美國德州大學安德森癌症中心 訪問學者
1999/08 -2005/07 國立臺灣大學醫學院 毒理學研究所 所長
1993/02 -1999/07 國立臺灣大學醫學院 毒理學研究所 副教授
1991/05 -1993/01 國立臺灣大學醫學院 毒理學研究所 講師
1989/02 -1989/07 中央研究院生醫所 博士後研究員

 

1. 癌症病因學及浸襲與轉移機制研究: -在癌症進程中調控遠端轉移、腫瘤血管新生及抗藥性之重要基因調控機轉

2. 腫瘤幹細胞在癌進程中扮演之角色
2.1 代謝體學(metabonomic)﹣找出腫瘤幹細胞特殊代謝物及代謝路徑。
2.2 表觀遺傳調控(epigenetic regulation)﹣表觀基因體在腫瘤幹細胞維持與分化之角色。
2.3 腫瘤幹細胞與微核醣核酸(microRNA)交互調控分析。

3. 尋找應用於新藥開發之癌症分子及細胞標靶或訊息傳遞路徑

2015 Chang JS, Su CY, Yu WH, Lee WJ, Liu YP, Lai TC, Jan YH, Yang YF, Shen CN, Shew JY, Lu J, Yang CJ, Huang MS, Lu PJ, Lin YF, Kuo ML, Hua KT, Hsiao M. GIT1 promotes lung cancer cell metastasis through modulating Rac1/Cdc42 activity and is associated with poor prognosis. Oncotarget. 2015 Oct 8. doi: 10.18632/oncotarget.5531
2015 Hsiao SM, Chen MW, Chen CA, Chien MH, Hua KT, Hsiao M, Kuo ML, Wei LH. The H3K9 Methyltransferase G9a Represses E-cadherin and is Associated with Myometrial Invasion in Endometrial Cancer. Ann Surgical Oncology, 2015 Jan; doi:10.1245/s10434-015-4379-5
2015 Wu MH, Lee WJ, Hua KT, Kuo ML, Lin MT. Macrophage Infiltration Induces Gastric Cancer Invasiveness by Activating the β-Catenin Pathway. PLoS One. 2015 Jul 30;10(7):e0134122.
2015 Chen CH, Kuo ML, Wang JL, Liao WC, Chang LC, Chan LP, Lin J. CCM-AMI, a Polyethylene Glycol Micelle with Amifostine, as an Acute Radiation Syndrome Protectant in C57BL/6 Mice. Health Phys. 2015 Sep;109(3):242-8.
2015 Chien MH, Lee WJ, Hsieh FK, Li CF, Cheng TY, Wang MY, Chen JS, Chow JM, Jan YH, Hsiao M, Hua KT, Kuo ML*. Keap1-Nrf2 Interaction Suppresses Cell Motility in Lung Adenocarcinomas by Targeting the S100P Protein. Clin Cancer Res,2015 Oct15;21(20):4719-32.
2015 Sheen YS, Liao YH, Lin MH, Chu CY, Ho BY, Hsieh MC, Chen PC, Cha ST, Jeng YM, Chang CC, Chiu HC, Jee SH, Kuo ML, Chu CY. IMP-3 promotes migration and invasion of melanoma cells by modulating the expression of HMGA2 and predicts poor prognosis in melanoma. J Invest Dermatol. 2015 Apr;135(4):1065-73.
2014 Chen WT, Yang TS, Chen HC, Chen HH, Chiang HC, Lin TC, Yeh CH, Ke TW, Chen JS, Hsiao KH, Kuo ML. Effectiveness of a novel herbal agent MB-6 as a potential adjunct to 5-fluoracil-based chemotherapy in colorectal cancer. Nutr Res. 2014 Jul;34(7):585-94.
2014 Hua KT, Wang MY, Chen MW, Wei LH, Chen CK, Ko CH, Jeng YM, Sung PL, Jan YH, Hsiao M, Kuo ML*, Yen ML. The H3K9 methyltransferase G9a is a marker of aggressive ovarian cancer that promotes peritoneal metastasis. Mol Cancer. 2014 Aug 12;13(1):189.
2014 Chang YW, Su CM, Su YH, Ho YS, Lai HH, Chen HA, Kuo ML, Hung WC, Chen YW, Wu CH, Chen PS, Su JL. Novel peptides suppress VEGFR-3 activity and antagonize VEGFR-3-mediated oncogenic effects. Oncotarget. 2014 Jun 15;5(11):3823-35.
2014 Chang CC, Lin BR, Wu TS, Jeng YM, Kuo ML. Input of microenvironmental regulation on colorectal cancer: role of the CCN family. World J Gastroenterol. 2014 Jun 14;20(22):6826-31.
2014 Lai CF, Lin SL, Chiang WC, Chen YM, Wu VC, Young GH, Ko WJ, Kuo ML, Tsai TJ, Wu KD. Blockade of Cysteine-rich Protein 61 Attenuates Renal Inflammation and Fibrosis after Ischemic Kidney Injury. Am J Physiol Renal Physiol. 2014 Sep 1;307(5):F581-92.
2014 Cheng TY, Wu MS, Lin JT, Lin MT, Shun CT, Hua KT, Kuo ML. Formyl Peptide receptor 1 expression is associated with tumor progression and survival in gastric cancer. Anticancer Res. 2014 May;34(5):2223-9.
2014 Yang PW, Huang YC, Hsieh CY, Hua KT, Huang YT, Chiang TH, Chen JS, Huang PM, Hsu HH, Kuo SW, Kuo ML, Lee JM. Association of miRNA-related Genetic Polymorphisms and Prognosis in Patients with Esophageal Squamous Cell Carcinoma. Ann Surg Oncol. 2014 Dec;21 Suppl 4:S601-9.
2014 Ling YS, Liang HJ, Lin MH, Tang CH, Wu KY, Kuo ML, Lin CY. Two-dimensional LC-MS/MS to enhance ceramide and phosphatidylcholine species profiling in mouse liver. Biomed Chromatogr. 2014 Sep;28(9):1284-93.
2014 Cheng TY, Wu MS, Hua KT, Kuo ML, Lin MT. Cyr61/CTGF/Nov family proteins in gastric carcinogenesis. World J Gastroenterol. 2014 Feb 21;20(7):1694-700.
2014 Wu MH, Wang MY, Yang CY, Kuo ML, Lin MT. Randomized Clinical Trial of New Intravenous Lipid (SMOFlipid(R) 20%) Versus MCT/LCT in Adult Patients Undergoing Gastrointestinal Surgery. JPEN J Parenter Enteral Nutr. 2014 Sep;38(7):800-8.
2014 Hua KT, Lee WJ, Yang SF, Chen CK, Hsiao M, Ku CC, Wei LH, Kuo ML, Chien MH. Vascular endothelial growth factor-C modulates proliferation and chemoresistance in acute myeloid leukemic cells through an endothelin-1-dependent induction of cyclooxygenase-2. Biochim Biophys Acta. 2014 Feb;1843(2):387-97.
2014 Chen CK, Yang CY, Hua KT, Ho MC, Johansson G, Jeng YM, Chen CN, Chen MW, Lee WJ, Su JL, Lai TC, Chou CC, Ho BC, Chang CF, Lee PH, Chang KJ, Hsiao M, Lin MT, Kuo ML. Leukocyte cell-derived chemotaxin 2 antagonizes MET receptor activation to suppress hepatocellular carcinoma vascular invasion by protein tyrosine phosphatase 1B recruitment. Hepatology. 2014 Mar;59(3):974-85.
2013 Tsai MS, Kuo ML, Chang CC, Wu YT. The effects of exercise training on levels of vascular endothelial growth factor in tumor-bearing mice. Cancer Biomark. 2013;13(5):307-13.
2013 Yang SJ, Lin CF, Kuo ML, Tan CT. Photodynamic detection of oral cancers with high-performance chitosan-based nanoparticles. Biomacromolecules. 2013 Sep 9;14(9):3183-91.
2013 Chien MH, Lee LM, Hsiao M, Wei LH, Chen CH, Lai TC, Hua KT, Chen MW, Sun CM, Kuo ML. Inhibition of Metastatic Potential in Breast Carcinoma In Vivo and In Vitro through Targeting VEGFRs and FGFRs. Evid Based Complement Alternat Med. 2013;2013:718380.
2013 Chu CY, Sheen YS, Cha ST, Hu YF, Tan CT, Chiu HC, Chang CC, Chen MW, Kuo ML, Jee SH. Induction of chemokine receptor CXCR4 expression by transforming growth factor-β1 in human basal cell carcinoma cells. J Dermatol Sci. 2013 Nov;72(2):123-33.
2013 Chou CH, Lai SL, Chen CN, Lee PH, Peng FC, Kuo ML, Lai HS. IL-6 regulates Mcl-1L expression through the JAK/PI3K/Akt/CREB signaling pathway in hepatocytes: implication of an anti-apoptotic role during liver regeneration. PLoS One. 2013 Jun 25;8(6):e66268.
2013 Chang CC, Hsu WH, Wang CC, Chou CH, Kuo MY, Lin BR, Chen ST, Tai SK, Kuo ML, Yang MH. Connective tissue growth factor activates pluripotency genes and mesenchymal-epithelial transition in head and neck cancer cells. Cancer Res. 2013 Jul 1;73(13):4147-57.
2013 Lai CF, Chen YM, Chiang WC, Lin SL, Kuo ML, Tsai TJ. Cysteine-rich protein 61 plays a proinflammatory role in obstructive kidney fibrosis. PLoS One. 2013;8(2):e56481.
2013 Kuo TC, Tan CT, Chang YW, Hong CC, Lee WJ, Chen MW, Jeng YM, Chiou J, Yu P, Chen PS, Wang MY, Hsiao M, Su JL, Kuo ML. Angiopoietin-like protein 1 suppresses SLUG to inhibit cancer cell motility. J Clin Invest. 2013 Mar 1;123(3):1082-95.
2013 Wei LH, Chou CH, Chen MW, Rose-John S, Kuo ML, Chen SU, Yang YS. The role of IL-6 trans-signaling in vascular leakage: implications for ovarian hyperstimulation syndrome in a murine model. J Clin Endocrinol Metab. 2013 Mar;98(3):E472-84.
2013 Chang CC, Yang MH, Lin BR, Chen ST, Pan SH, Hsiao M, Lai TC, Lin SK, Jeng YM, Chu CY, Chen RH, Yang PC, Chin Y Eugene and Kuo ML*. CCN2 inhibits lung cancer metastasis through promoting DAPK-dependent anoikis and inducing EGFR degradation. Cell Death and Differentiation. 2013 Mar;20(3):443-55.
2011 Chen PS, Su JL, Cha ST, Tarn WY, Wang MY, Hsu HC, Lin MT, Chu CY, Hua KT, Chen CN, Kuo TC, Chang KJ, Hsiao M, Chang YW, Chen JS, Yang PC, Kuo ML*. miR-107 promotes tumor progression by targeting the let-7 microRNA in mice and humans. J Clin Invest. 2011 Sep 1;121(9):3442-55.
2011 Lin BR, Chang CC, Chen RJ, Jeng YM, Liang JT, Lee PH, Chang KJ, Kuo ML*. Connective tissue growth factor acts as a therapeutic agent and predictor for peritoneal carcinomatosis of colorectal cancer. Clin Cancer Res. 2011 May 15;17(10):3077-88.
2011 Yen ML, Hou CH, Peng KY, Tseng PC, Jiang SS, Shun CT, Chen YC, Kuo ML*. Efficient Derivation & Concise Gene Expression Profiling of Human Embryonic Stem Cell-Derived Mesenchymal Progenitors (EMPs). Cell Transplant. 2011;20(10):1529-45.
2011 Hua KT, Tan CT, Johansson G, Lee JM, Yang PW, Lu HY, Chen CK, Su JL, Chen PB, Wu YL, Chi CC, Kao HJ, Shih HJ, Chen MW, Chien MH, Chen PS, Lee WJ, Cheng TY, Rosenberger G, Chai CY, Yang CJ, Huang MS, Lai TC, Chou TY, Hsiao M, Kuo ML*. N-α-acetyltransferase 10 protein suppresses cancer cell metastasis by binding PIX proteins and inhibiting Cdc42/Rac1 activity. Cancer Cell. 2011 Feb 15;19(2):218-31.
2010 Chen MW, Hua KT, Kao HJ, Chi CC, Wei LH, Johansson G, Shiah SG, Chen PS, Jeng YM, Cheng TY, Lai TC, Chang JS, Jan YH, Chien MH, Yang CJ, Huang MS, Hsiao M, Kuo ML*.H3K9 histone methyltransferase G9a promotes lung cancer invasion and metastasis by silencing the cell adhesion molecule Ep-CAM. Cancer Res. 2010 Oct 15;70(20):7830-40.
2010 Cha ST, Chen PS, Johansson G, Chu CY, Wang MY, Jeng YM, Yu SL, Chen JS, Chang KJ, Jee SH, Tan CT, Lin MT, Kuo ML*. MicroRNA-519c suppresses hypoxia-inducible factor-1alpha expression and tumor angiogenesis. Cancer Res. 2010 Apr 1;70(7):2675-85.
2009 Chien MH, Ku CC, Johansson G, Chen MW, Hsiao M, Su JL, Inoue H, Hua KT, Wei LH, Kuo ML*. Vascular endothelial growth factor-C (VEGF-C) promotes angiogenesis by induction of COX-2 in leukemic cells via the VEGF-R3/JNK/AP-1 pathway. Carcinogenesis. 2009 Dec;30(12):2005-13.
2009 Wang MY, Chen PS, Prakash E, Hsu HC, Huang HY, Lin MT, Chang KJ, Kuo ML*. Connective tissue growth factor confers drug resistance in breast cancer through concomitant up-regulation of Bcl-xL and cIAP1. Cancer Res. 2009 Apr 15;69(8):3482-91.
2009 Chu CY, Cha ST, Lin WC, Lu PH, Tan CT, Chang CC, Lin BR, Jee SH, Kuo ML*. Stromal cell-derived factor-1alpha (SDF-1alpha/CXCL12)-enhanced angiogenesis of human basal cell carcinoma cells involves ERK1/2-NF-kappaB/interleukin-6 pathway. Carcinogenesis. 2009 Feb;30(2):205-13.
2008 Chu CY, Chang CC, Prakash E, Kuo ML*. Connective tissue growth factor (CTGF) and cancer progression. J Biomed Sci. 2008 Nov;15(6):675-85.
2008 Su JL, Chen PS, Chien MH, Chen PB, Chen YH, Lai CC, Hung MC, Kuo ML*. Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. Cancer Cell. 2008 Jun;13(6):557-60.
2008 Tan CT, Chu CY, Lu YC, Chang CC, Lin BR, Wu HH, Liu HL, Cha ST, Prakash E, Ko JY, Kuo ML*.  CXCL12/CXCR4 promotes laryngeal and hypopharyngeal squamous cell carcinoma metastasis through MMP-13-dependent invasion via the ERK1/2/AP-1 pathway. Carcinogenesis. 2008 Aug;29(8):1519-27.
2008 Lin MT, Kuo IH, Chang CC, Chu CY, Chen HY, Lin BR, Sureshbabu M, Shih HJ, Kuo ML*. Involvement of hypoxia-inducing factor-1alpha-dependent plasminogen activator inhibitor-1 up-regulation in Cyr61/CCN1-induced gastric cancer cell invasion. J Biol Chem. 2008 Jun 6;283(23):15807-15.
2007 Lin MT, Chang CC, Lin BR, Yang HY, Chu CY, Wu MH, Kuo ML*. Elevated expression of Cyr61 enhances peritoneal dissemination of gastric cancer cells through integrin alpha2beta1. J Biol Chem. 2007 Nov 23;282(47):34594-604.
2007 Chen PS, Wang MY, Wu SN, Su JL, Hong CC, Chuang SE, Chen MW, Hua KT, Wu YL, Cha ST, Babu MS, Chen CN, Lee PH, Chang KJ, Kuo ML*. CTGF enhances the motility of breast cancer cells via an integrin-alphavbeta3-ERK1/2- dependent S100A4-upregulated pathway. J Cell Sci. 2007 Jun 15;120(Pt 12):2053-65.
2007 Lin MT, Lin BR, Chang CC, Chu CY, Su HJ, Chen ST, Jeng YM, Kuo ML*. IL-6 induces AGS gastric cancer cell invasion via activation of the c-Src/RhoA/ROCK signaling pathway. Int J Cancer. 2007 Jun 15;120(12):2600-8.
2007 Chu CY, Cha ST, Chang CC, Hsiao CH, Tan CT, Lu YC, Jee SH, Kuo ML*. Involvement of matrix metalloproteinase-13 in stromal-cell-derived factor 1 alpha-directed invasion of human basal cell carcinoma cells. Oncogene. 2007 Apr 12;26(17):2491-501.
2006 Chang CC, Lin MT, Lin BR, Jeng YM, Chen ST, Chu CY, Chen RJ, Chang KJ, Yang PC, Kuo ML*. Effect of connective tissue growth factor on hypoxia-inducible factor 1alpha degradation and tumor angiogenesis. J Natl Cancer Inst. 2006 Jul 19;98(14):984-95.
2006 Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML*. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 2006 Mar;9(3):209-23.