研究室: 臺大生化館 R403
電 話:

(02)33664071 ; (02)23665541

傳 真: (02)23635038
地 址:

(10617)
台北市大安區羅斯福路四段1號
國立臺灣大學生化科學研究所

電子信箱: gdchang@ntu.edu.tw

1988 美國伊利諾大學生理及生物物理系 博士
1980 國立臺灣大學生化科學研究所  碩士
1978 國立臺灣大學動物系 學士

1995~ 國立臺灣大學 理學院 生化科學研究所 教授
1989-1995 國立臺灣大學 理學院 生化科學研究所 副教授
1988-1989 美國伊利諾大學 博士後研究
1982-1984 美國伊利諾大學 助教

Cell responses to oxidative stress
Target identification of small-molecule drugs
Analytical techniques for metabolites by LC-Mass Spectrometry
Analytical techniques for protein oxidation modifications

  余承翰、黃偉杰、李昱蓉、何雅曄

2015 Yu, CH, Chou, CC. Ho, YY. Khoo, KH. andChang GD*. Target identification by specific tagging and antibody detection (TISTA) reveals the action mechanism of afatinib on cell cycle, In submission
2015 Huang, WC. Lee, DY, and Chang GD*. Target identification of small-molecule compounds by affinity elution in tandem hydrophobic interaction chromatography (AETHIC) reveals RKIP regulating ERK signaling in an ATP-dependent manner, in submission
2015 Lin SJ, Lee DY, Wang HC, Kang ST, Hwang PP, Kou GH, Huang MF, Chang GD*, Lo CF*. (2015) White Spot Syndrome Virus Protein Kinase 1 (PK1) Defeats the Host Cell's Iron Withholding Defense Mechanism by Interacting with Host Ferritin. J. Virol. 89, 1083-1093
2015 Lee, DY and Chang GD* (2015), Post-staining electroblotting for reliable peptide blotting, Methods Mol. Biol. 1312:185-195
2015 Lee, DY and Chang GD* (2015), Simultaneous Immunoblotting Analysis with Activity Gel Electrophoresis and 2-D Gel Electrophoresis, Methods Mol. Biol. 1312:61-72
2015 Yu, C.H., Chou, C.C., Lee, Y.J., Khoo, K.Y., and Chang GD*. (2015) Uncovering Protein Polyamination by the Spermine-specific Antiserum and Mass Spectrometric Analysis, Amino Acids, 47, 469–481
2015 Lee, D.Y. and Chang GD* (2015), Quantitative LC-ESI-MS analysis of amine-containing metabolites derivatized with cyanuric chloride and methylamine isotopologues, J. Chromatography A, 1338, 60-68
2014 Su MA, Huang YT, Chen IT, Lee DY, Hsieh YC, Li CY, Ng TH, Liang SY, Lin SY, Huang SW, Chiang YA, Yu HT, Khoo KH, Chang GD, Lo CF, Wang HC. (2014) An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway. PLoS Pathog. 12;10(6):e1004196.
2014 Lee, DY and Chang GD* (2014), Methylglyoxal in cells elicits a negative feedback loop entailing transglutaminase 2 and glyoxalase 1, Redox Biology, 2, 196-205
2012 Ho WH, Lee DY, Chang GD*. (2012) Proteomic Identification of a Novel Hsp90-Containing Protein-Mineral Complex Which Can Be Induced in Cells in Response to Massive Calcium Influx, J Proteome Res. 11, 3160−3174.
2012 Huang JY, Liu WJ, Wang HC, Lee DY, Leu JH, Wang HC, Tsai MH, Kang ST, Chen IT, Kou GH, Chang GD*, Lo CF*. (2012) Penaeus monodon thioredoxin restores the DNA binding activity of oxidized white spot syndrome virus IE1, Antioxid Redox Signal., 17, 914-926.
2011 Lin, F.Y., Chang, C.W., Cheong, M.L., Chen, H.C., Lee, D.Y., Chang, G.D*., Chen, H*. ( 2011 ) Dual-specificity phosphatase 23 mediates GCM1 dephosphorylation and activation, Nucleic Acids Res., 39(3), 848-61.
2010 Huang, H.R., Chen, Z.J., Kunes, S., Chang, G.D., and Maniatis, T. ( 2010 ) Endocytic pathway is required for Drosophila Toll innate immune signaling, Proc. Natl. Acad. Sci. USA. 107, 8322-8327.
2009 Lee, D.Y. and Chang G.D. ( 2009 ) Electrolytic reduction: modification of proteins occurring in isoelectric focusing electrophoresis and in electrolytic reactions in the presence of high salts, Anal. Chem., 81, 3957-3964.
2009 Lee, D.Y. and Chang G.D. ( 2009 ) Simultaneous immunoblotting analysis with activity gel electrophoresis and 2-D gel electrophoresis, Methods Mol. Biol., 536, 23-33.
2004 Tsai, P.L., Chen, C.H., Huang, C.J., Chou, C.M. and Chang, G.D. ( 2004 ) Purification and cloning of an endogenous protein inhibitor of carp nephrosin, an astacin metalloproteinase, J. Biol. Chem., 279, 11146-11155.
1997 Hung, C. H., Huang, H. R., Huang, C. J., Huang, F. L. and Chang, G. D. ( 1997 ) Purification and cloning of carp nephrosin, a secreted zinc endopeptidase of the Astacin family, J. Biol. Chem., 272, 13772-13778.
1998 張震東 (1998) 神經細胞的結構, pp 61-83, "心與腦", 徐嘉宏主編, 台北: 心理出版社
1998 張震東 (1998) 神經細胞的生理學, pp 84-106, "心與腦", 徐嘉宏主編, 台北: 心理出版社